Bioprocess and Biosystems Engineering

Development of general methods and tools of bioprocess and biosystems engineering and their applications for bioprocess development in industrial and pharmaceutical biotechnologies.

Stichworte

• Biogas
• Biokatalyse
• Biokonversion
• Bioprozesstechnik
• Bioraffinerie
• Bioreaktor
• Biosystems Engineering
• Biotechnologie
• Fermentationstechnik

Publikationen

• Uwe Jandt, Oscar Platas Barradas, Ralf Pörtner and An-Ping Zeng: Synchronized mammalian cell culture: Part II Population ensemble modeling and analysis for development of reproducible processes. Biotechnol. Proress., 2014 (accepted), 2014 (accepted).
• T. Kaeding, D. Tjahjasari and A.-P. Zeng: 1,3-Propanediol and Polytrimethyleneterephthalate. Elsevier, , 2011
• Liu, Yuan-Hua and Bi, Jing-Xiu and Zeng, An-Ping and Yuan, Jing-Qi: A cybernetic model to describe the dynamics of myeloma cell cultivations Applied Mathematics and Computation, 205(1): S. 84--97, 2008.
• Chen, L and Zeng, A and Dong, H and Li, Q and Niu, C: A novel process for recovery and refining of L-lactic acid from fermentation broth Bioresour Technol, 112: S. 280--284, 2012.
• Liu, Y H and Bi, J X and Zeng, A P and Yuan, J Q: A population balance model describing the cell cycle dynamics of myeloma cell cultivation Biotechnol Prog, 23(5): S. 1198--1209, 2007.
• Liu, Y H and Bi, J X and Zeng, A P and Yuan, J Q: A simple kinetic model for myeloma cell culture with consideration of lysine limitation Bioprocess Biosyst Eng, 31(6): S. 569--577, 2008.
• : Alginates: Biology and Applications. Springer Berlin Heidelberg, , 2009
• Sabra, Wael; Dietz, David; Tjahjasari, Donna; Zeng, An-Ping : Biosystems analysis and engineering of microbial consortia for industrial biotechnology Engineering in Life Sciences(10): S. 407-421, 2010.
• Dietz, D and Sabra, W and Zeng, A P: Co-cultivation of Lactobacillus zeae and Veillonella cricetifor the production of propionic acid AMB Express, 3(1): S. 29, 2013.
• Chen, Z and Bommareddy, R R and Frank, D and Rappert, S and Zeng, A P: Deregulation of feedback inhibition of phosphoenolpyruvate carboxylase for improved lysine production in Corynebacterium glutamicum Appl Environ Microbiol, 80(4): S. 1388--1393, 2014.
• Chatzifragkou, A and Dietz, D and Komaitis, M and Zeng, A P and Papanikolaou, S: Effect of biodiesel-derived waste glycerol impurities on biomass and 1,3-propanediol production of Clostridium butyricum VPI 1718 Biotechnol Bioeng, 107(1): S. 76--84, 2010.
• Dietz, D and Zeng, A P: Efficient production of 1,3-propanediol from fermentation of crude glycerol with mixed cultures in a simple medium Bioprocess Biosyst Eng, 37(2): S. 225--233, 2014.
• Metsoviti, M and Zeng, A P and Koutinas, A A and Papanikolaou, S: Enhanced 1,3-propanediol production by a newly isolated Citrobacter freundii strain cultivated on biodiesel-derived waste glycerol through sterile and non-sterile bioprocesses J Biotechnol, 163(4): S. 408--418, 2013.
• Geng, F and Chen, Z and Zheng, P and Sun, J and Zeng, A P: Exploring the allosteric mechanism of dihydrodipicolinate synthase by reverse engineering of the allosteric inhibitor binding sites and its application for lysine production Appl Microbiol Biotechnol, 97(5): S. 1963--1971, 2013.
• Zheng, P and Sun, J and Geffers, R and Zeng, A P: Functional characterization of the gene PA2384 in large-scale gene regulation in response to iron starvation in Pseudomonas aeruginosa J Biotechnol, 132(4): S. 342--352, 2007.
• Chatzifragkou, A and Aggelis, G and Komaitis, M and Zeng, A P and Papanikolaou, S: Impact of anaerobiosis strategy and bioreactor geometry on the biochemical response of Clostridium butyricum VPI 1718 during 1,3-propanediol fermentation Bioresour Technol, 102(22): S. 10625--10632, 2011.
• Sabra, W and Groeger, C and Sharma, P N and Zeng, A P: Improved n-butanol production by a non-acetone producing Clostridium pasteurianum DSMZ 525 in mixed substrate fermentation Appl Microbiol Biotechnol, 98(9): S. 4267--4276, 2014.
• Julian A. da Luz, Enrico Hans and An-Ping Zeng : Improvement of intracellular metabolite analysis of microorganisms by automated fast filtration and on-filter quenching Eng. Life Sciences: S. 135-142, 2014.
• Ardao, I and Hwang, E T and Zeng, A P: In vitro multienzymatic reaction systems for biosynthesis Adv Biochem Eng Biotechnol, 137: S. 153--184, 2013.
• Gu, MB and Zeng, An-Ping: Industrial biotechnology in Asia - recent advances in biofuels and biorefinery Engineering in Life Sciences, 13(5): S. 419--420, sep 2013.
• Li, J and Wang, W and Ma, Y and Zeng, A P: Medium optimization and proteome analysis of (R,R)-2,3-butanediol production by Paenibacillus polymyxa ATCC 12321 Appl Microbiol Biotechnol, 97(2): S. 585--597, 2013.
• Ulmer, C. and Zeng, A.P.: Microbial Production of 3-hydroxypropionaldehyde from Glycerol Bioconversion Chemical & Biochemical Engineering Quarterly, 21(4): S. 321--326, dec 2007.
• Sabra, Wael and Zeng, An Ping: Microbial Production of Alginates: Physiology and Process Aspects. In Rehm, Bernd H. A., Hrsg., Alginates: Biology and Applications , Jg. 13 von Microbiology Monographs, S. 153--173. Springer Berlin Heidelberg, 2009.
• Wael Sabra, Jian-Ying Dai, Hendrich Quitmann, A.-P. Zeng and Zhi-Long Xiu: Microbial production of 2, 3-butanediol. . Elsevier , , 2011
• Zeng, A P and Sabra, W: Microbial production of diols as platform chemicals: recent progresses Curr Opin Biotechnol, 22(6): S. 749--757, 2011.
• Wurm, M and Schopke, B and Lutz, D and Muller, J and Zeng, A P: Microtechnology meets systems biology: the small molecules of metabolome as next big targets J Biotechnol, 149(1-2): S. 33--51, 2010.
• Jiang, J and Ji, X and Zeng, A and Chen, X: Modeling of Spodoptera litura nuclear polyhedral virus epidemic at different temperatures Ying Yong Sheng Tai Xue Bao, 17(2): S. 275--279, 2006.
• Zeng, A P: New biotechnological production systems Biotechnol J, 6(8): S. 907--908, 2011.
• Yu, B and Sun, J and Bommareddy, R R and Song, L and Zeng, A P: Novel (2R,3R)-2,3-butanediol dehydrogenase from potential industrial strain Paenibacillus polymyxa ATCC 12321 Appl Environ Microbiol, 77(12): S. 4230--4233, 2011.
• Zhang, Qingrui and Xiu, Zhilong and Zeng, An-Ping: Optimization of microbial production of 1,3-propanediol by Klebsiella pneumoniae under anaerobic and microaerobic conditions by metabolic flux analysis Journal of Chemical Industry and Engineering (China), 57(6): S. 1403--1409, 2006.
• Zheng, Ping and Wereath, Kirsten and Sun, Jibin and van den Heuvel, Joop and Zeng, An-Ping: Overexpression of genes of the dha regulon and its effects on cell growth, glycerol fermentation to 1,3-propanediol and plasmid stability in Klebsiella pneumoniae Process Biochemistry, 41(10): S. 2160--2169, oct 2006.
• Hilterhaus, L and Minow, B and Muller, J and Berheide, M and Quitmann, H and Katzer, M and Thum, O and Antranikian, G and Zeng, A P and Liese, A: Practical application of different enzymes immobilized on sepabeads Bioprocess Biosyst Eng, 31(3): S. 163--171, 2008.
• Xiu, Z L and Zeng, A P: Present state and perspective of downstream processing of biologically produced 1,3-propanediol and 2,3-butanediol Appl Microbiol Biotechnol, 78(6): S. 917--926, 2008.
• Chatzifragkou, A and Papanikolaou, S and Dietz, D and Doulgeraki, A I and Nychas, G J and Zeng, A P: Production of 1,3-propanediol by Clostridium butyricum growing on biodiesel-derived crude glycerol through a non-sterilized fermentation process Appl Microbiol Biotechnol, 91(1): S. 101--112, 2011.
• Metsoviti, Maria and Paraskevaidi, Kleopatra and Koutinas, Apostolis and Zeng, An-Ping and Papanikolaou, Seraphim: Production of 1,3-propanediol, 2,3-butanediol and ethanol by a newly isolated Klebsiella oxytoca strain growing on biodiesel-derived glycerol based media Process Biochemistry, 47(12): S. 1872--1882, dec 2012.
• Chen, Zhen and Jandt, Uwe and Rappert, Sugima and Zeng, An-Ping: Proteindesign für die Entwicklung von industriellen Mikroorganismen BIOspektrum, 19(1): S. 99--101, feb 2013.
• Wang, W and Sun, J and Hollmann, R and Zeng, A P and Deckwer, W D: Proteomic characterization of transient expression and secretion of a stress-related metalloprotease in high cell density culture of Bacillus megaterium J Biotechnol, 126(3): S. 313--324, 2006.
• Oehmke, Sebastian and Zeng, An-Ping: Recovery of biologically produced 3-hydroxypropionaldehyde and its dehydrated product acrolein Engineering in Life Sciences: S. n/a--n/a, jun 2014.
• Metsoviti, Maria and Paramithiotis, Spiros and Drosinos, Eleftherios H. and Galiotou-Panayotou, Maria and Nychas, George-John E. and Zeng, An-Ping and Papanikolaou, Seraphim: Screening of bacterial strains capable of converting biodiesel-derived raw glycerol into 1,3-propanediol, 2,3-butanediol and ethanol Engineering in Life Sciences, 12(1): S. 57--68, feb 2012.
• Aydogan, Özlem and Bayraktar, Emine and Mehmetoğlu, Ülkü and Kaeding, Thomas and Zeng, An-Ping: Selection and optimization of an aqueous two-phase system for the recovery of 1,3-propandiol from fermentation broth Engineering in Life Sciences, 10(20): S. 121--129, mar 2010.
• Rieckenberg, F and Gotz, K and Hilterhaus, L and Liese, A and Zeng, A P: Strategies for reliable and improved large-scale production of Pyrococcus furiosus with integrated purification of hydrogenase I Bioprocess Biosyst Eng, 2014.
• Sabra, W and Dietz, D and Zeng, A P: Substrate-limited co-culture for efficient production of propionic acid from flour hydrolysate Appl Microbiol Biotechnol, 97(13): S. 5771--5777, 2013.
• Deckwer, W.-D. and Hempel, D. C. and Zeng, A.-P. and Jahn, D.: Systembiotechnologische Ansätze zur Prozessentwicklung Chemie Ingenieur Technik, 78(3): S. 193--208, mar 2006.
• Deckwer, W.-D. and Jahn, D. and Hempel, D. and Zeng, A.-P.: Systems Biology Approaches to Bioprocess Development Engineering in Life Sciences, 6(5): S. 455--469, oct 2006.
• Sun, J and Zeng, A-P: Systems Biology. In , Hrsg., Report on the Development of Industrial Biotechnology . The Bureau of Life Science & Biotechnology, CAS, Beijing, 2008.