Professoren | |
Prof. Dr. rer. nat. An-Ping Zeng (Leitung) | ( TUHH ) |
em. Prof.-Dr.-Ing. Herbert Märkl | (TUHH) |
Sekretariat | |
Cornelia Hoffmann | (TUHH) |
wissenschaftliche Mitarbeiter/innen | |
Priv.-Doz. Dr.-Ing. habil. Ralf Poertner | (TUHH (Oberingenieur)) |
Dr. rer.nat. Christiane Goepfert | (E-Learning Consortium, AIF) |
Dipl.-Biotech David Dietz | (TUHH) |
M. Sc. Hendrich Quitmann | ( TUHH) |
Dipl.-Biotech Matthias Wurm | (TUHH) |
sonstige Mitarbeiter/innen | |
Dipl.-Ing. (FH) Ralf Grajetzki | (TUHH) |
Jan Sens | (TUHH) |
Dipl.-Ing. (FH) Thomas Linz | (Industrie) |
Kerstin Michael | (DFG) |
Gäste | |
Dr. Marcin Bizukojc | () |
Bohmann. A. ; R. Pörtner; J. Schmieding; V. Kasche; H. Märkl: Integrated membrane dialysis bioreactor with radial-flow fixed bed - a new approach for continuous cultivation of animal cells,"Cytotechnology, 9,"51-57, 1992".
Bohmann, A. ; R. Pörtner; H. Märkl,"Evaluation of optimal process parameters for the membrane dialysis bioreactor with integrated radial fixed bed; In,"Kaminogawa, S. ; Ametani, A. ; Hachimura, S. ; Animal Cell Technology,"Basic & Applied Aspects, Vol. 5, Kluwer Academic Publishers, 1993. ".
Lüdemann, I.; R. Pörtner and H. Märkl,"Effect of NH3 on the cell growth of a hybridoma cell line; Cytotechnology 14,"11-20 (1994) ".
Pörtner, R.; A. Bohmann; I. Lüdemann and H. Märkl,"Estimation of specific glucose uptake rates in cultures of hybridoma cells,"Journal of Biotechnology 34,"237-246 (1994)".
Ong, C.P.; R. Pörtner; H. Märkl; Y. Yamazaki; K. Yasuda and M. Matsumura,"High density cultivation of hybridoma in charged porous carriers; Journal of Biotechnology 34,"259-268 (1994)".
A. Bohmann; R. Pörtner and H. Märkl,"Performance of a membrane dialysis bioreactor with radial-flow fixed bed for the cultivation of a hybridoma cell line; Appl. Microbiol. Biotechnol. 43,"772-780 (1995) ".
Pörtner, R.; A. Schilling; I, Lüdemann and H. Märkl: High density fed-batch cultures for hybridoma cells performed with the aid of a kinetic model. Bioprocess Engineering 15 (1996) 117-124
Lüdemann, I., R. Pörtner, C. Schaefer, K. Schick, K. Srámková, K. Reher, M. Neumaier, F. Franék and H. Märkl: Improvement of the culture stability of non-anchorage-dependent animal cells grown in serum-free media through immobilization. Cytotechnology 19 (1996) 111-124
Reinhold, G., S. Merrath, F. Lennemann and H. Märkl: Modelling the hydrodynamics and the fluid mixing behaviour of a Biogas Tower Reactor. Chem. Eng. Sci. 51,17 (1996) 4065-4073
Pörtner, R., I. Lüdemann und H. Märkl: Dialysekulturen mit immobilisierten tierischen Zellen. Biospektrum 6 (1996) 47-49
Pörtner, R.; I. Lüdemann and H. Märkl: Dialysis cultures with immobilized hybridoma cells for effective production of monoclonal antibodies. Cytotechnology 23: 39-45 (1997)
Pörtner, R.; I. Lüdemann; K. Reher; M. Neumaier; H. Märkl:(1998) Fixed-bed dialysis culture of a transfectoma cell line producing chimeric Fab-fragments with "nutrient-split"-feeding strategy. Biotechnol. Tech. 12,7: 501-505 (1998)
Pörtner, R. and H. Märkl: Dialysis cultures. Appl. Microbiol. Biotechnol. 50: 403-414 (1998)
Schwabe, J.O.; R. Pörtner and H. Märkl: Improving an on-line feeding strategy for fed-batch cultures of hybridoma cells by dialysis and "nutrient-split"-feeding. Bioproc. Eng. 20, 6: 475 - 484 (1999)
Pörtner, R. and Th. Schäfer: Modelling hybridoma cell growth and metabolism - A comparision of selected models and data; Journal of Biotechnology 49: 119-135 (1996)
Fassnacht, D.; S. Rössing; N. Ghaussy and R. Pörtner: Influence of non-essential amino acids on apoptotic and necrotic death of mouse hybridoma cells in batch cultures. Biotechnology Letters 19: 35-38 (1997)
Pörtner, R.; S. Rössing; M. Koop and I. Lüdemann: Kinetic studies on hybridoma cells immobilized in fixed bed reactos. Biotechnology and Bioengineering, 55, 3: 535-541 (1997)
Pörtner, R.; S. Rössing und D. Fassnacht: Festbettreaktoren mit immobilisierten tierischen und menschlichen Zellen. Bioscope 9: 25-33 (1997)
Pörtner, R. and M. Koop: A model for oxygen supply in fixed bed reactors with immobilized hybridoma cells. Bioprocess Engineering 17: 269-275 (1997)
Fassnacht, D.; S. Rössing; J. Stange and R. Pörtner: Long-term cultivation of immortalised mouse hepatocytes in a high cell density fixed bed reactor. Biotechnology Techniques 12: 25-30 (1998)
Fassnacht, D.; S. Rössing; F. Franék; M. Al-Rubeai and R. Pörtner: Effect of BCL-2 Expression on hybridoma cell growth in serum-supplemented, protein-free and diluted media. Cytotechnology 26 (3): 219-225 (1998)
Fassnacht, D.; S. Rössing; R. Singh; M. Al-Rubeai and R. Pörtner: Influence of BCL-2 Expression on antibody productivity in high cell density hybridoma culture systems. Cytotechnology 30: 95-105 (1999)
Fassnacht, D. and R. Pörtner: Experimental and theoretical considerations on oxygen supply for animal cell growth in fixed bed reactors. Journal of Biotechnology 72 (3): 169 - 184 (1999)
Manusadzianas, L.; R. Vitkas; R. Pörtner and H. Märkl: Phytotoxicities of selected chemicals and industrial effluents to Nitellopsis obtusa cells, assessed by using a rapid electrophysiological Charophyte test. ATLA, 27: 379-386 (1999)
Nehring, D., P. Adamietz, N. M. Meenen and R. Pörtner: Perfusion cultures and modelling of oxygen uptake with three-dimensional chondrocyte pellets. Biotechnology Techniques 13: 701-706 (1999)
Pörtner, R.; D. Fassnacht and H. Märkl: Immobilization of mammalian cells in fixed bed reactors. BIOforum International 3: 140-141 (1999)
Fussenegger, M.; D. Fassnacht; R. Schwartz; J. A. Zanghi; M. Graf, J. E. Bailey and R. Pörtner: Regulated overexpression of the survival factor bcl-2 in CHO cells increases viable cell density in batch culture and decreases DNA release in extended fixed-bed cultivation. Cytotechnology 32: 45-61 (2000)
Fassnacht, D.; I. Reimann, R. Pörtner und H. Märkl: Scale-up von Festbettreak-toren zur Kultivierung tierischer Zellen. Chemie Ingenieur Technik 73: 1075 - 1079 (2001)
Frahm, B.; H.-C. Blank; P. Cornand; W. Oelßner; U. Guth; P. Lane; A. Munack; K. Johannsen and R. Pörtner: Determination of dissolved CO2 concentration and CO2 production rate of mammalian cell suspension culture based on off-gas measurement. Journal of Biotechnology 99/2: 133-148 (2002)
Frahm, B.; P. Lane; H. Atzert; A. Munack; M. Hoffmann; V. Hass and R. Pörtner: Adaptive, model-based control by the Open-Loop-Feedback-Optimal (OLFO) controller for the effective fed-batch cultivation of hybridoma cells. Biotechnology Progress 18: 1095-1103 (2002)
Nagel-Heyer, St. and R. Pörtner: Bioreactor cultivation for three-dimensional cartilage implants. G.I.T. Laboratory Journal 2: 66-67 (2002)
Frahm, B. und R. Pörtner: Reaktor-Abgasmessungen bei Zellkulturen, BIOforum 4, 2002
Frahm, B., Hass, V. C., Lane, P., Munack, A., Märkl, H. and R. Pörtner: Fed-batch Kultivierung tierischer Zellen - eine Herausforderung zur adaptiven, modellbasierten Steuerung, Chemie Ingenieur Technik, vol. 4, pp. 457 460 (2003)
Frahm, B., Lane, P., Märkl, H. and R. Pörtner: Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis, Bioprocess and Biosystems Engineering, vol. 26, pp. 1-10 (2003)
Nehring, D.; P. Czermak; S. Gokorsch und R. Pörtner: Produktion retroviraler Partikel im Festbettreaktor. BioWorld 4: 14-15 (2003)
Nehring, D.; R. Gonzales; P. Czermak and R. Pörtner: Mathematical model of a mem-brane filtration process using ceramic membranes to increase retroviral pseudotype vector titer. Journal of Membrane Science 237: 25-38 (2004)
Pörtner, R.; J.-O. Schwabe and B. Frahm: Evaluation of selected control strategies for fed-batch cultures of a hybridoma cell line, Biotechnology and Applied Biochemistry 40: 47-55 (2004)
Nagel-Heyer, S.; R. Janßen; C. Goepfert; P. Adamietz; N.M. Meenen and R. Pörtner: Carti-lage cultivation on a calcium phosphate ceramic in a bioreactor system. Key Engineering Materials 264-268: 2119-2122 (2004)
Janssen, R.; S. Nagel-Heyer; Ch. Goepfert; R. Pörtner; D. Toykan; O. Krummhauer; M.M. Morlock; P. Adamietz; N.M. Meenen; W.M. Kriven; D.-K. Kim; A. Tampieri and G. Celotti: Cal-cium phosphate ceramics as substrate for cartilage cultivation. Ceramic Engineering and Sci-ence Proceedings 25, 4: 523-528 (2004)
Pörtner, R.; M. Seemuk; R.-Ch. Schlothauer; D. Elsser: Anaerobe Kultivierung von Lactococcus lactis im Festbettreaktor. Chemie-Ingenieur-Technik, 76, 10: 1599-1602 (2004)
Nagel-Heyer, S.; Ch. Goepfert; M.M. Morlock and R. Pörtner: Relationship between gross morphological and biochemical data of tissue engineered cartilage-carrier-constructs. Biotechnology Letters, 27(3): 187-192 (2005)
Nagel-Heyer, S.; Ch. Goepfert; M.M. Morlock and R. Pörtner: Relationship between gross morphological and biochemical data of tissue engineered cartilage-carrier-constructs. Biotechnology Letters 27(3): 187-192 (2005)
Frahm, B.; P. Lane, A. Munack und R. Pörtner: Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. Chemie-Ingenieur-Technik, 77 (4), 429 – 435 (2005)
Nagel-Heyer, S.; Ch. Goepfert; P. Adamietz; N.M. Meenen; J.-P. Petersen and R. Pörtner: Flow-chamber bioreactor culture for generation of three-dimensional cartilage-carrier-constructs. Bioprocess and Biosystems Engineering, 27: 273-280 (2005)
Meenen, N.M., P. Ueblacker, R. Pörtner, C. Göpfert, S. Nagel-Heyer, J. P. Petersen und P. Adamietz: ; „ Knorpel aus dem Labor-eine Sackgasse?“,. Arthroskopie 18: 245-252 (2005)
Pörtner, R.; St. Nagel-Heyer; Ch. Goepfert; P. Adamietz and N. M. Meenen: Bioreactor design for tissue engineering. Journal of Bioengineering and Bioscience, 100(3): 235-245 (2005)
Hass, V.C.; Kuhnen, F.; Schoop, K.-M.; Poertner, R.: Integration of computer based learning and training in bioprocess technical training. Chemie-Ingenieur-Technik, 77(8), 1250-1251 (2005)
Pörtner, R.; Hass, V.C.: Interactive virtual learning environment for biotechnology (eLearnBioTec). Chemie-Ingenieur-Technik, 77(8), 1256 (2005)
Nagel-Heyer, St.; Ch. Goepfert; P. Adamietz; N. M. Meenen and R. Pörtner: Cultivation of three-dimensional cartilage-carrier-constructs under reduced oxygen tension. Journal of Biotechnology, 121 (4), 486-497 (2006)
Nehring, D.; R. Gonzales; R. Pörtner and P. Czermak: Experimental and modelling study of different process modes for retroviral production in a fixed bed reactor. Journal of Biotechnology, 122 (2), 239-253 (2006)
Heyland, J.; K. Wiegandt; Ch. Goepfert; St. Nagel-Heyer; E. Ilinich; U. Schumacher and R. Pörtner: Redifferentiation of chondrocytes and cartilage formation under intermittent hydrostatic pressure. Biotechnology Letters, 28: 1641-1648 (2006)
Becker, Th; B. Hitzmann; R. Pörtner; K.F. Reardon; F. Stahl and R. Ulber: Future Aspects of Biopro-cess Monitoring. in: D. Sell, R. Ulber (Eds.); White Biotechnology; Advances in Biochemical Engineer-ing/Biotechnology; Springer Verlag 105 (2007) 249-293
Petersen, J.-P.; P. Uebelacker; Ch. Goepfert; P. Adamietz; A. Stork; J.M. Rueger; R. Pörtner; M. Amling and N.M. Meenen: Long term results after implantation of tissue engineered cartilage for the treatment of osteochondral lesions in a minipig model. Journal of Materials Science: Materials in Medicin, DOI: 10.1007/s10856-007-3291-3
R. Pörtner, O.B. Platas, D. Fassnacht, D. Nehring, P. Czermak, H. Märkl: Fixed bed reactors for the cultivation of mammalian cells: design, performance and scale-up. Open Biotechnology Journal, 1: 41-46 (2007)
Weber, Ch.; S. Pohl; R. Pörtner; Ch. Wallrapp; M. Kassem; P. Geigle and P. Czermak: Expansion and Harvesting of hMSC-TERT. The Open Biomedical Engineering Journal, 1: 38-46 (2007)
Weber, Ch.; S. Pohl; R. Pörtner; Ch. Wallrapp; M. Kassem; P. Geigle and P. Czermak: Cultivation and Differentiation of Encapsulated hMSC-TERT in a Disposable Small-Scale Syringe-Like Fixed Bed Reactor. The Open Biomedical Engineering Journal, 1: 64-70 (2007)
C. Ulmer and A.-P. Zeng (2007). Microbial production of 3-hydroxypropionaldehyde from glycerol bioconversion. Chem. Biochem. Eng. Q. 21; 321-326
P. Zheng, J Sun, R. Geffers, A.-P. Zeng (2007) Functional characterization of the gene PA2384 in large scale gene regulation in response to iron starvation in Pseudomonas aeruginosa. J. Biotechnol. 132: 342-352.
Y.-H. Liu, J.-X. Bi, A.-P. Zeng, J.-Q. Yuan (2007). A population balance model describing the cell cycle dynamics of myeloma cell cultivation. Biotechnol. Prog. 23:1198-1209.
Pel,H.J., de Winde,J.H., Archer,D.B., Dyer,P.S., Hofmann,G., Schaap,P.J., Turner,G., de Vries,R.P., Albang,R., Albermann,K., Andersen,M.R., Bendtsen,J.D., Benen,J.A., van den,B.M., Breestraat,S., Caddick,M.X., Contreras,R., Cornell,M., Coutinho,P.M., Danchin,E.G., Debets,A.J., Dekker,P., van Dijck,P.W., van Dijk,A., Dijkhuizen,L., Driessen,A.J., d'Enfert,C., Geysens,S., Goosen,C., Groot,G.S., de Groot,P.W., Guillemette,T., Henrissat,B., Herweijer,M., van den Hombergh,J.P., van den Hondel,C.A., van der Heijden,R.T., van der Kaaij,R.M., Klis,F.M., Kools,H.J., Kubicek,C.P., van Kuyk,P.A., Lauber,J., Lu,X., van der Maarel,M.J., Meulenberg,R., Menke,H., Mortimer,M.A., Nielsen,J., Oliver,S.G., Olsthoorn,M., Pal,K., van Peij,N.N., Ram,A.F., Rinas,U., Roubos,J.A., Sagt,C.M., Schmoll,M., Sun,J., Ussery,D., Varga,J., Vervecken,W., van de Vondervoort,P.J., Wedler,H., Wosten,H.A., Zeng,A.P., van Ooyen,A.J., Visser,J., Stam,H. (2007) Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88. Nat.Biotechnol. 25: 221-231.
F. He, J. Buer, A.-P. Zeng, R. Balling (2007) Dynamic cumulative activity of transcription factors as a mechanism of quantitative gene regulation in multi-regulator transcriptional regulatory motifs. Genome Biology. 8:R181
J. Sun, X. Liu, U. Rinas and A.-P. Zeng (2007) Metabolic pecularities of Aspergillus niger disclosed by comparative metabolic genomics. Genome Biology. 8:R182
Q. Zhang, H. Teng, Y. Sun, Z. Xiu and A.-P. Zeng (2007) Metabolic flux and robustness analysis of glycerol metabolism in Klebsiella pneumoniae. Bioprocess Biosyst Eng. In print.
M. da Silva, H. Ma, J.Sun, F. He, A.-P. Zeng (2007) Metabolic network. In B. H. Junker, F. Schreiber (eds.) Biological Network Analysis, Wiley: 233-253
B. Ma, F. He, J. Jablonska, S. Winkelbach, W. Lindenmaier, A.-P. Zeng, and K. Dittmar. A system approach for six-colour segmentation analysis of multi-colour images in the infection studies of Listeria monocytogenes. Microscopy Research & Technique. 2007, 70 (2):171-178.
Ma H., Rosa da Silva M., Sun J., Kumar B., Zeng A.-P. (2007) Reconstruction and Structural Analysis of Metabolic and Regulatory Networks. In: "Introduction to Systems Biology". Eds. Sangdun Choi, Humana Press.
Zhou F, Bi JX, Zeng AP, Yuan JQ. Macrokinetic model for myeloma cell culture based on stoichiometric balance. Biotechnol Appl Biochem. (2007) 46: 85-95.
Y. Li, J. Bi, W. Zhou, Y. Huang, L. Sun, A.-P. Zeng, G. Ma, Z. Su. (2007) Characterization of the large size aggregation of Hepatitis B virus surface antigen (HBsAg) formed in ultrafiltration process. Process Biochemistry. 42: 315-319.
Q. Zhang, Z.-L. Xiu and A.-P. Zeng (2006) Optimization of microbial production of 1,3-propanediol by Klebsiella pneumoniae under anaerobic and microaerobic conditions by metabolic flux analysis. J. Chem. Ind. Eng. 57, 1403-1409.
W. Wang, J. Sun, R. Homann, A.-P. Zeng and W-d. Deckwer (2006) Proteomic characterization of transient expression and secretion of a stress-related metalloprotease in high cell density culture of Bacillus megaterium. J. Biotechnology. 126: 313-324.
Zheng P, Sun J, van den Heuvel J, Zeng AP. Discovery and investigation of a new, second triose phosphate isomerase in Klebsiella pneumoniae. J Biotechnol. 2006. 125(4):462-473.
Zeng AP. Editorial. Process Biochemistry (Special Issue: From Biochemical Engineering to Systems Biology - In honour of Dr. Wolf-Dieter Deckwer). 2006. 41(10):2101-2102
Zheng P, Wereath K, Sun J, van den Heuvel J and Zeng AP. Overexpression of genes of the dha regulon and its effects on cell growth, glycerol fermentation to 1,3-propanediol and plasmid stability in Klebsiella pneumoniae. Process Biochemistry. 2006. 41(10):2160-2169
Zhou F, Bi J, Zeng AP and Yuan J. A macrokinetic and regulator model for myeloma cell culture based on metabolic balance of pathways. Process Biochemistry. 2006. 41(10):2207-2217
J. Sun, W. Wang, C. Hundertmark, A.-P. Zeng, D. Jahn and W.-D. Deckwer (2006). A protein database constructed from low-coverage genomic sequence of Bacillus megaterium and its use for accelerated proteomic analysis. J. Biotechnol. 124(3):486-95.
W.-D. Deckwer, D. Jahn, D. Hempel, A.-P. Zeng (2006) System Biology Approach to Bioprocess Development. Life Science Eng. 6: 455-469.
W.-D. Deckwer, D. Jahn, A.-P. Zeng, D. Hempel (2006) Systembiologische Ansätze zur Prozessentwicklung. Chem. Ing. Tech. 78, 193-207.
F. He and A.-P. Zeng (2006) In search of functional association of genes from time-series microarry expression data by a new method based on change trend and expression levels of genes. BMC Bioinformatics 7:69.
Jan Buer, Astrid M. Westendorf, An-Ping Zeng, Wiebke Hansen & Michael Probst-Kepper (2005) Mechanisms of central and peripheral T cell tolerance: An update. Transfus Med Hemother. 32: (DOI:10.1159/000089128)
Zhang F., Bi J.X., Zeng A.-P., Yuan J.Q. (2005) A simple kinetic model for myeloma cell growth with lysin as a limiting substrate. J. of Shanghai Jiaotong University. 139, 182-186.
Zhang F., Bi J.X., Zeng A.-P., Yuan J.Q. (2005) A simple kinetic model for myeloma cell growth with lysin as a limiting substrate. J. of Shanghai Jiaotong University. 139, 182-186.
A.-P. Zeng and J. Bi (2005) Cell Culture Kinetics and Modeling. In: S.S. Ozturk and W.-S. Hu (eds.) Cell Culture Technology for Pharmaceutical and Cellular Therapies. Taylor & Francis Group, Atlanta. pp: 299-347.
B. Kumar, H. Ma and A.-P. Zeng (2005) An integrated cellular network of Escherichia coli and its structural analysis. Proceedings of Foundation of Systems Biology in Engineering. University of California, Santa Babara, USA, August 7-10. pp 107-110.
H. Ma, A.-P. Zeng (2005) Reconstruction of metabolic network from genome information and its structural and functional analysis. In: R. Eils and A. Kriete (Eds.) Computational Systems Biology, Elsevier Inc., USA. Pp: 169-189.
Sun J, Gunzer F, Buer J, Gößling F, Scharfe M, Blöcker H and Zeng AP (2005). Genomic peculiarity of coding sequences and metabolic potential of the probiotic Escherichia coli strain Nissle 1917 inferred from raw genome sequence. J. Biotechnol. 117 (2): 147-161.
A.-P. Zeng, J. Sun, W. Wang, H. Ma and W.-D. Deckwer (2006) Application of genomic and proteomic data for bioprocess analysis and optimisation. In S.T. Yang (ed.) Bioprocessing for value-added products from renewable resources. Elservier Inc, USA. Pp: 25-48.
E.-J. Kim, W.-D. Deckwer, W. Wang and A.-P. Zeng (2005) Expression of the quorum sensing regulator protein LasR of is strongly affected by iron deficiency and oxygen concentration in Pseudomonas aeruginosa irrespective of cell density. Microbiology, 151: 1127-1138.
H. Ma, B. Kumar, U. Ditges, Gunzer F, J. Buer and A.-P. Zeng (2004) An extended transcriptional regulatory network of Escherichia coli and analysis of its hierarchical structure and network motifs. Nucleic Acids Res. 32: 6643-6649
H. Ma, J. Buer and A.-P. Zeng (2004) Hierarchical structure and modules in the Escherichia coli transcriptional regulatory network revealed by a new top-down approach. BMC Bioinformatcs, 5:199.
J. Sun, R. Daniel, I. Wagner-Döbler and A.-P. Zeng (2004) Is autoinducer-2 a universal signal for interspecies communication? A comparative and phylogenetic genomic analysis of the synthesis and signal transduction pathways. BMC Evolutionary Biology, 4:36.
J Sun and A.-P. Zeng (2004) IDENTICS - Identification of coding sequences and in silico reconstruction of the metabolic network directly from unannotated low-coverage bacterial genome sequences. BMC Bioinformatics, 5:112.
U Ditges, M Hartmann, S Coldewey, HW Ma, AP Zeng, F Gunzer (2004) Acid resistance in enterohemorrhagic E-coli: Is there a link to the serotype? International Journal of Medical Microbiology 294:161-161 Suppl. 39.
H. Ma, X.-M. Zhao, Y-J. Yuan and A.-P. Zeng (2004) Decomposition of metabolic network into functional modules based on the global connectivity structure of reaction graph. Bioinformatics. 20: 1870-1876
H. Ma and A.-P. Zeng (2004) Phylogenetic comparasion of metabolic capacities of organisms at genome level. Molecular Phylogenetics and Evolution. 31, 204-213.
F. He, H. Ma, X.-M. Zhao, Y.-J. Yuan, A.-P. Zeng (2004) Progress and perspective in the application of bioinformatics for the analysis of metabolic networks. J. Chem. Ind. Eng. (Chinese). 55:1593-1601.
A.-P. Zeng and E.-J. Kim (2004) Iron availability, oxygen limitation, Pseudomonas aeruginosa and cystic fibrosis. Microbiology. 150: 516-518.
Z.-L. Xiu, B.-H. Song, Z.-T. Wang, L.-H. Sun, E.-M. Feng and A.-P. Zeng (2004) Optimization of dissimilation of glycerol to 1,3-propanediol by Klebsiella pneumoniae in one- and two-stage anaerobic cultures. Biochem. Eng. J., 19: 189¿197
H. Ma and A.-P. Zeng (2003) The connectivity structure, giant strong component and centrality of metabolic networks. Bioinformatics. 19: 1423-1430
H. Ma and A.-P. Zeng (2003) Reconstruction of metabolic networks from genome data and analysis of their global structure for various organisms. Bioinformatics. 19: 270-277.
W. Wang, J. Sun, M. Nimtz, W.-D. Deckwer and A.-P. Zeng (2003) Protein identification from 2-dimentional gel electrophoresis analysis of Klebsiella pneumoniae by combined use of mass spectrometry data and unannotated genome sequences. Proteome Science. 1, 6.
J. Sun, J. van den Heuvel, P. Soucaille and A.-P. Zeng (2003) Comparative genomic analysis of dha regulon and related genes for anaerobic glycerol metabolism in microorganisms. Biotechnol. Prog. 19: 263-272.
W. Wang, J. Sun, M. Hartlep, W.-D. Deckwer and A.-P. Zeng. (2003) Combined use of proteomic analysis and enzyme activity assay for metabolic pathway analysis of glycerol fermentation by Klebsiella pneumoniae. Biotechnol. Bioeng. 83: 525-536.
J.-J. Qiao, Y.-J. Yuan, H. Zhao1, J.-C. Wu and A.-P. Zeng (2003) Apoptotic cell death in suspension cultures of Taxus cuspidata co-treated with salicylic acid and hydrogen peroxide. Biotechnology Letters 25: 387¿390.
Qiao JJ, Zhao H, Ge ZQ, Yuan YJ, Zeng AP (2003). 2-dimensional gel electrophoresis on protein patterns from suspension cultures of Taxus cuspidate induced by SA.
Chinese Journal of Biotechnology. 19(1): 92-96
E.-J. Kim, W. Sabra, A.-P. Zeng (2003) Iron deficiency leads to inhibition of oxygen transfer and enhanced formation of virulence factors in Pseudomonas aeruginosa cultures. Microbiology 149, 2627-2634.
J.-X. Bi, P. Buhr, A.-P. Zeng and M. Wirth (2003) The Human c-fos Promoter Mediates High-level, Inducible Expression in Various Mammalian Cell Lines. Biotechnol. Bioeng. 81: 845-854.
W. Sabra, H. Lünsdorf and A.-P. Zeng (2003) Alterations in the formation of lipopolysaccharide and membrane vesicle on the surface of Pseudomonas aeruginosa PAO1 under oxidative stress conditions. Microbiology. 149, 2789-2795.
J. Bi, M. Wirth, C. Beer, E.-J. Kim and A.-P. Zeng (2002) Dynamic characterization of recombinant Chinese Hamster Ovary cells containing an inducible c-fos promoter GFP expression system as a biomarker. J. Biotechnol. 93: 231-242.
A.-P. Zeng and H. Biebl (2002) Bulk-Chemicals from Biotechnology: the case of microbial production of 1,3-propanediol and the new trends. In K. Schügerl and A.-P. Zeng (Eds.) Tools and Applications of Biochemical Engineering Science. Adv. Biochem. Eng. Biotechnol. Vol. 74: 237-257.
Z.-Y. Ma; Y.-J. Yuan; J.-C. Wu and A.-P. Zeng (2002) Apoptotic cell death in suspension cultures of Taxus chinensis var. mairei. Biotechnol. Letters 24(7): 573-577.
Y.-J. Yuan, Z.-Y. Ma, J.-C. Wu and A.-P. Zeng (2002) Taxol-induced apoptotic cell death in suspension cultures of Taxus cuspidate. Biotechnol. Letters 24(8): 615-618.
Yuan, Y.-J., Li, C., Hu, Z.-D., J-C. Wu, Zeng, A.-P. (2002) Fungal Elicitor-Induced Cell Apoptosis in Suspension Cultures of Taxus chinensis var. mairei for Taxol Production. Process Biochem. 38: 193-198.
Xiu, Z.-L., Song , B.-H., Sun, L.-H. and Zeng, A.-P. (2002) Theoretical analysis of effects of metabolic overflow and time delay on the performance and dynamic behavior of a two-stage fermentation process. Biochemical Eng. J. 11, 101-109.
Xiu, Z.-L., Chang, Z.-Y. and Zeng, A.-P. (2002) Nonlinear dynamics of regulation of bacterial trp operon: model analysis of integrated effects of repression, feedback inhibition and attenuation. Biotechnol. Progress. 18. 686-693
A.-P. Zeng, J. Modak and W.-D. Deckwer (2002) Nonlinear dynamics of eucaryotic pyruvate dehydrogenase multi-enzyme complex: Decarboxylation rate, oscillations and multiplicity. Biotechnol. Prog. 18: 1265-1276
J. Modak, W.-D. Deckwer and A.-P. Zeng (2002) Metabolic control analysis of eucaryotic pyruvate dehydrogenase multi-enzyme complex. Biotechnol. Prog. 18: 1157-1169.
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