Most managerial decision problems require answers to questions such as “what happens to Y if we do X?”, or “was it X that caused Y to change?” In other words, practical business decision-making requires knowledge about cause-and-effect. While most data science and machine learning approaches are designed to efficiently detect patterns in high-dimensional data, they are not able to distinguish causal relationships from simple correlations. That means, commonly used approaches to business analytics often fall short to provide decision makers with important causal knowledge. Therefore, many leading companies currently try to develop specific causal data science capabilities. This module will provide an introduction into the topic of causal inference with the help of modern data science and machine learning approaches and with a focus on applications to practical business problems from various management areas. Based on an overarching framework for causal data science, the course will guide students to detect sources of confounding influence factors, understand the problem of selective measurement in data collection, and extrapolate causal knowledge across different business contexts. We also cover several tools for causal inference, such as A/B testing and experiments, difference-in-differences, instrumental variables, matching, regression discontinuity designs, etc. A variety of hands-on examples will be discussed that allow students to apply their newly obtained knowledge and carry out state-of-the-art causal analyses by themselves.