Continuous Polymerization in Modular, Intelligent Reactors Resistant to the Formation of Deposits (KoPPonA 2.0)

The main objective of the ENPRO 2.0 initiative is to increase energy efficiency of new production processes. A number of energy demanding and inefficient processes are allocated within the German chemical industry, especially the production of pharmaceutical, fine and special chemicals. The concerned products are mostly produced utilizing multi-product plants and small batch processes due to small throughput. During the first phase of the ENPRO 1.0 initiative (2014-2017) the project partners have developed flexible, scalable and modular plant concepts. Micro-structured devices have been proven to suit requirements for the combined product and process development. However, one drawback of micro-structured mixers, reactors and heat exchangers for continuous processes is the formation of gel or solid particles leading to fouling and blocking of the device.

The KoPPonA 2.0 project drives the development of continuous process concepts for polymer production which are sensitive to fouling. A conglomerate of plant operators, equipment and sensor suppliers, material scientists and process engineers work together in KoPPonA 2.0 to research causes and preventive measures of fouling. KoPPonA 2.0 uses innovative approaches in plant design, surface modification, and reaction control are used to allow efficient and safe operation of continuous polymerization processes. By investigating basic fouling mechanisms in continuous polymerization processes a universal comprehension of fouling is to be derived.

The Institute of Multiphase Flows (V-5) generates a comprehensive computational fluid dynamics (CFD) model of the process components that are prone to fouling. The model incorporates hydrodynamic flow phenomena, mass transfer, kinetics and different fouling mechanisms. The models are validated by means of Confocal Laser Scanning Microscopy (CLSM) to visualize three-dimensional concentration distribution at micro scale (resolution down to 1 μm) with Laser-Induced Fluorescence (LIF). Furthermore, reactive models are validated by means of the novel imaging UV/Vis spectroscopy developed at the IMS.

Graduate Teaching Assistant

• Process Design Course WiSe 19/20

• Computional Fluid Dynamics in Process Engineering SoSe 20, SoSe 21, SoSe 22, and SoSe 23

• Lagrangian Transport in Turbulent Flows SoSe 20 and SoSe 21

• Turbulent Flows SoSe 22 and SoSe 23

Supervised Theses

• "Education 4.0: Development of an Extended Reality Tool for CFD-aided Design and Development of a Shell-Tube Heat Exchanger (working title)", Jeswin Kannampuzha Francis, Master thesis, ongoing

• "Experimentelle Bestimmung der Löslichkeit von Stickstoffmonixid in Methanol mithilfe einer chemischen Reaktion", Xuan My Le, Project thesis, 2023

• "Experimentelle Untersuchung der laminaren Mikrovermischung in einem Kaskadenmischer durch konfokale LIF-Messung einer reaktiven Strömung", Anna-Christin Menzel, Master thesis, 2023

• "Analysis of Transport Barriers in Continuous Mixers by means of Lagrangian Coherent Structures", Christoph Wigger, Master thesis, 2023

• "Experimenteller Vergleich der bildgebenden und globalen UV/Vis-Spektroskopie zur Charakterisierung der Mikromischung in einem Kaskadenmischer", Xuan My Le, Master thesis, 2023

• "Comparison of the Lattice-Boltzmann Method and Finite Volume Method in continuously operated static mixers - a CFD benchmark study", Roman Neubauer, Master thesis, 2023

• "Erstellung einer 1D- und 3D-CFD Methodik zur Berechnung und Optimierung einer neuen innovativen Wärmetauscher-Technologie im Motorsport", Hendrik Doß, Master thesis, 2022

• "Experimentelle Untersuchung des Mischverhaltens in einem Milli-Kaskadenmischer bei kleinen Reynoldszahlen mit Hilfe der konfokalen Laserscanning-Mikroskopie", Sabrina Bauschmann, Bachelor thesis, 2022

• "Effect of a Chemical Reaction on Grid Convergence of a Direct Numerical Simulation", Chandrahas Rao Sampelli, Project thesis, 2022

• "Experimental Investigations of Mixing in a Split and Recombine Mixer using Confocal Laser Scanning Microscopy", Nithin Thonakkara James, Project Work, 2021

• "Numerische Simulation der Mischleistung in einem strukturierten Rohrreaktor bei einem hohen Viskositätsverhältnis der Teilströme", Vincent Bernemann, Master thesis, 2021

• "Experimentelle Untersuchung der Übertragbarkeit eines Mischprozesses vom Labordissolver auf eine duale asymmetrische Zentrifuge bei wässrigen Lacksystemen", Gerrit Spiller, Master thesis, 2021

• „Numerische Simulation einer parallel-kompetitiven chemischen Reaktion mit steifem Differentialgleichungssystem in einem mikro-strukturierten Strömungskanal bei kleinen Reynoldszahlen", Tobias Freund, Master thesis, 2021

• "Comparison of Active and Passive Micro Mixers Designed for Asymmetric Mixing Tasks", Kayla Reata Dittmer, Bachelor thesis, 2020

• "Experimental Analysis of the Mixing Performance in Micro Channels at High Volume Flow Ratios and Low Reynolds Numbers", Rieke Schlütemann, Bachelor thesis, 2020

Lectures

• Frey, T., Hoffmann, M., Schlüter, M.: "Experimental and CFD Study on Local Selectivity Distributions in a Stiff Reactive System", 14th ECCE and 7th ECAB, Berlin, 2023, lecture.

• Frey, T., Grabellus, M., Le, X. M., Hoffmann, M., Herbstritt, F., Grünewald, M., Schlüter, M.: "Local interpretation of micro mixing through the Villermaux-Dushman reaction and the imaging UV-Vis spectroscopy", 17th European Conference on Mixing, Porto, 2023, lecture.

• Schwarz, S.; Grünewald, M.; Biessey, P.; Frey, T.; Schlüter, M.; Hoffmann, M.: "CFD-based compartment modeling approach for continuous polymer reactors by means of the Mean-Age theory". (Bio)Process Engineering - a Key to Sustainable Development, joint event of ProcessNet, DECHEMA-BioTechNet Jahrestagungen 2022, 13th ESBES Symposium, Aachen, 2022, lecture.

• Frey, T.; Hoffmann, M.; Schlüter, M.: "Visualizing Reactive Mixing Phenomena with the Novel Imaging UV/Vis Spectroscopy in Asymmetric and Transient Flows". (Bio)Process Engineering - a Key to Sustainable Development, joint event of ProcessNet, DECHEMA-BioTechNet Jahrestagungen 2022, 13th ESBES Symposium, Aachen, 2022, lecture.

• Frey, T.; Hoffmann, M.; Schlüter, M.: "Visualizing Reactive Mixing Phenomena in Milli and Micro Channels". NAMF Mixing XXVII, virtual, 2022, lecture.

• Frey, T.; Schwarz, S.; Biessey, P.; Hoffmann, M.; Grünewald, M; Schlüter, M.: "Modeling Polymer Fouling with an Euler-Lagrangian Approach in a Milli-Reactor with Static Mixing Elements". 13th ECCE, virtual, 2021, lecture.

Poster Presentations

• Frey, T.; Schwarz, S.; Hoffmann, M.; Grünewald, M.; Schlüter, M.: "CFD unterstützte Auslegung und Compartment modellierung eines kontinuierlich betriebenen Reaktorsystems für Polymerisationsreaktionen". Jahrestreffen der ProcessNet-Fachgemeinschaft "Prozess-, Apparate- und Anlagentechnik", Frankfurt a. M., 2022, poster presentation.

• Schwarz, S.; Frey, T.; Hoffmann, M.; Biessey, P.; Schlüter, M.; Grünewald, M: "CFD-based compartment modeling of static mixing elements for continuous polymer reactors by means of the Mean-Age theory". Annual Meeting on Reaction Engineering and ProcessNet Subject Division Heat and Mass Transfer 2022, Würzburg, 2022, poster presentation.

• Frey, T.; Hoffmann, M.; Schlüter, M.: "A DNS Approach to high-Schmidt-Number problems in Reactive Micro- and Milli Systems". NAMF Mixing XXVII, virtual, 2022, poster presentation.

• Schwarz, S.; Frey, T.; Hoffmann, M.; Biessey, P.; Schlüter, M.; Grünewald, M: "Compartmentmodellierung von statischen Mischelementen mithilfe der Mean-Age Theorie". Jahrestreffen der ProcessNet-Fachgemeinschaft "Prozess-, Apparate- und Anlagentechnik", virtual, 2021, poster presentation.

• Frey, T.; Schwarz, S.; Seithümmer, V.; Bissey, P.; Hoffmann, M.; Grünewald, M.; Schlüter, M.: "Numerische Strömungssimulation zum Einfluss auf den Umsatz und die Selektivität einer Polymerisationsreaktion". Jahrestreffen der ProcessNet-Fachgemeinschaft "Prozess-, Apparate- und Anlagentechnik", virtual, 2020, poster presentation.

DFG Priority Program SPP 2170 “InterZell” – Project “CHOLife”: Multiscale experimental analysis and simulation of lifelines in bioreactors to study their impact on the cultivation performance of Chinese Hamster Ovary (CHO) cells

Large-scale bioreactors with working volumes up to 22,000 L are frequently exposed to dynamic cultivation conditions that create spatial and temporal gradients in mixing. These variations cause a decline in cellular performance, which ultimately results in lower product quality and quantity. Precise and reliable process control is critical for biopharmaceutical production of vaccines and monoclonal antibodies, as well as for understanding the impact of dynamically changing environments on cells. For the detailed understanding of cultivation processes it is indispensable to get deep insights into the overall and local hydrodynamics with high spatial and temporal resolution.

CHOLife tackles the scale-up problem linking the unique access to a transparent 15,000 L cell culture bioreactor (Institute of Multiphase Flows, TUHH Hamburg, IMS) with the development of a novel scale-up device (Institute of Biochemical Engineering, Stuttgart, IBVT) in order to predict industrial-scale performance of IgG1 producing CHO cells. In essence, three dimensional flow trajectories and lifelines will be measured at the IMS and mimicked in the novel scale-up simulator of IBVT. The close cooperation of both parties ensures a successful scale-down of large-scale conditions and an equally successful prediction of large-scale performance of CHO cells cultured in the novel scale-up simulator.

One method of gaining insight into complex hydrodynamic flow patterns and compartmentalization is by means of the (de)colorization method, which is based on phenolphthalein or bromothymol blue in an acrylic glass bioreactor. However, the lack of optical access into generic bioreactors requires an alternative analysis. Industrially used fixed probes at the reactor wall cannot provide information on spatiotemporal gradients or the cell's residence time in different zones of the reactor.

To overcome this limitation, Lapin et al. proposed the "Traveling along the Lifelines of Single Cells" approach, which uses a numerical method. This Lagrangian analysis was recently experimentally scrutinized on laboratory-scale through the 4D-Particle Tracking Velocimetry (4D-PTV) method demonstrating detailed results regarding the flow-following capability of Lagrangian particles.

On production scale, a combination of sensor systems integrated into a mobile, enclosed and neutrally buoyant Lagrangian Sensor Particle (LSP) offers a deeper understanding of complex flow patterns inside a bioreactor by recording data alongside its trajectory and thereby mimicking the movement of a cell.

• Maximilian Kamp as the winner of the “Karl H. Ditze Award of the TUHH to graduates of the TUHH” in the category of outstanding Bachelor thesis. The thesis convinced the committee in terms of theoretical-scientific quality, practical relevance and interdisciplinarity, which was written within the framework of the priority program SPP 2170 “InterZell” (funded by the DFG).

• Winner of the I3 Junior Project: Flow-following Lagrangian Sensor Particles - Development of a novel measurement technique with conductivity sensors for a novel macro-mixing and lifeline analysis; Hofmann, S.; Kamp, M.; Buntkiel, L.; Reinecke, S.; I3-Programm, sponsored by the Hamburg University of Technology for the project period 01/2023 - 03/2024

• DFG Priority Program 2170 – InterZell – CHOLife

Undergraduate courses

• Reactor Design Using Local Transport Processes (Winter Semester 2022/23)

• Reactor Design Using Local Transport Processes (Winter Semester 2021/22)

• Grundlagen des Technischen Zeichnens (Summer Semester 2021)

Supervised Theses

• "Effect of a Phosphate-Buffered System on the Determination of the Volumetric Mass Transfer Coefficient k_La for CO₂", Lara Offermann, Bachelor thesis (supervision in cooperation with Marc Maly and Nicolas Nickel), 2024

• "Measurement and modelling of carbon dioxide and oxygen partial pressures over the height of a 15,000 L acrylic glass reactor", working title, Noah von Schnitzler, Master thesis (supervision in cooperation with Marc Maly and Nicolas Nickel), 2024

• "Development, Implementation and Testing of a Technical Solution for the Determination of Gas Partial Pressures at Different Heights of an Aerated Stirred Tank Reactor on Industrial Scale", Noah von Schnitzler, project work (supervision in cooperation with Marc Maly and Nicolas Nickel), 2024

• "Lagrangian Sensor Particles in a 15,000 L Bioreactor: Experimental Comparison of Different Sizes on their Flow-Following Capability", Isabel Sophie Brouwers, Master's Thesis, 2024: Thesis available here and Python code available here.

• "Überblick und Bewertung von Bioprozesssensoren in Lagrangeschen Sensor Partikeln: Stand der Technik, Miniaturisierung und Weiterentwicklung", Julius Plock, Bachelor's Thesis, 2023

• "Experimental Investigations of the Flow-Following Capabilities and Hydrodynamic Characteristics of Lagrangian Sensor Particles with Respect to their Centre of Mass", Ryan Rautenbach, Master's Thesis, 2023: Python evaluation code available here.

• "Experimental investigation of the flow behavior of Lagrangian LED Particles in a 200 l bioreactor", Maximilian Kamp, Bachelor's Thesis, 2022: Thesis available here and MATLAB code available here.

• "Design, Construction and Evaluation of Lagrangian Sensor Particles for the Flow Behavior Determination in a 200 L and 15000 L Bioreactor", Paramveer Singh GopalSingh, Master's Thesis, 2023: Thesis available here and MATLAB and C++ code available here.

• "Experimental Characterization of Modified Polyurethane Foams for Mechanical Clean Up of Oil Pollutants at Sea Surface" (in close cooperation with Daniel Niehaus), Srividya Kumar Bairamangala, Project Work, 2020-2021

Lectures

• Hofmann, S.; Buntkiel, L.; Rautenbach, R.; Hampel, U,; Schlüter, M.: Comparing Trajectories from Lagrangian Sensor Particles and Lattice-Boltzmann Simulations in a 15,000 L Bioreactor, Mixing XXVIII & ISMIP 11 Conference, Banff, Alberta, Canada, 2024, Presentation
• Rautenbach, R.; Hofmann, S.; Buntkiel, L.; Barczyk, J.; Hoffmann, M.; Reinecke, S.; Takors, R.; Hampel, U.; Schlüter, M.: Simulation of Lagrangian Sensor Particles as Resolved Particles in an Industrial Bioreactor through Lattice-Boltzmann Large Eddy Simulations, 28th International Symposium on Chemical Reaction Engineering, Turku, Finland, 2024, Presentation
• Rautenbach, R.; Hofmann, S.; Buntkiel, L.; Barczyk, J.; Reinecke, S.; Hoffmann, M.; Takors, R.; Hampel, U.; Schlüter, M.: Resolved Particle Lattice-Boltzmann Large Eddy Simulation in a 15,000 L Bioreactor to mimic Lagrangian Sensor Particles, 8th BioProScale Symposium, Berlin, Germany, 2024, Presentation
• Hofmann, S.; Buntkiel, L.: Best Practices in Research Software Engineering: Working with MATLAB and Gitlab, 2nd "Technical Baldyga Seminar", 3rd "Mixing Meets Reality" Conference, Berlin, Germany, 2023, Presentation
• Hofmann, S.; Buntkiel, L.; GopalSingh, P.; Fitschen, J.; Hoffmann, M.; Reinecke, S.; Hampel, U,; Schlüter, M.: Experimental Investigation of Circulation Times with Lagrangian Sensor Particles in a 15,000 L Acrylic Glass Reactor, 17th European Conference on Mixing (MIXING 17), Porto, Portugal, 2023, Presentation
• Hofmann, S. - Lagrangian Particles: Experimental Determination of Lifelines in a 3 L and 15000 L Stirred Tank Reactor, Biobased Process and Reactor Technologies PhD Seminar, Hamburg University of Technology, Hamburg, 2022, Presentation
• Hofmann, S.; Gaugler, L.: CHOLife - Multiscale Experimental Analysis and Simulation of Lifelines in Bioreactors to Study their Impact on the Cultivation Performance of CHO Cells, Annual Meeting: Priority Program Status Meeting of the SPP2170 "InterZell", organized by Uni Stuttgart, Stuttgart, 2022, Presentation
• Fitschen, J.; Kuschel, M.; Hofmann, S.; Wucherpfennig, T.; v. Kameke, A.; Hoffmann, M.; Schlüter, M.: Characterization of Heterogeneities in Stirred Tank Reactors by Means of 4D Particle Trajectories and Numerical Flow Simulations, MIXING XXVII, North American Mixing Forum (NAMF), Online Conference 2022, Presentation
• Hofmann, S.; Vernier-Lambert, H.; Meriguet, S.; GopalSingh, P.; Fitschen, J.; Neubauer, P.; von Lieres, E.; Ferguson, M.; Schlüter, M.: Assessment of Lagrangian Sensor Particle Designs in a Transparent 15,000 L Acrylic Glass Bioreactor, 7th BioProScale Symposium, organized by Prof. Neubauer (TU Berlin), Langenbeck-Virchow-Haus, Berlin 2022, Presentation
• Gaugler, L.; Mast, Y.; Fitschen, J.; Hofmann, S.; Schlüter, M.; Takors, R.: Development of a single multi-compartment bioreactor (SMCB) for CHO scale-down studies in a heterogeneous cultivation environments, 7th BioProScale Symposium, organized by Prof. Neubauer (TU Berlin), Langenbeck-Virchow-Haus, Berlin 2022, Presentation
• Weiland, C; Hofmann, S.; Fitschen, J.; von Kameke, A.; Hoffmann, M.; Schlüter, M.: Numerische Simulation Lagranger Partikeltrajektorien und Charakterisierung des Partikelfolgevermögens in einem 3 L Rührkesselreaktor, Jahrestreffen der ProcessNet-Fachgruppen Computational Fluid Dynamics + Mischvorgänge + Agglomerations- und Schüttguttechnik, DECHEMA, Hyperion Hotel Leipzig, 2022, Presentation
• Fitschen, J.; Hofmann, S.; Hoffmann, M.; Kuschel, M.; Wucherpfennig, T.; Schlüter, M.: Lokale Mischzeitverteilung in begasten Rührkesselreaktoren im Labormaßstab, Jahrestreffen der ProcessNet-Fachgruppen Computational Fluid Dynamics + Mischvorgänge + Agglomerations- und Schüttguttechnik, DECHEMA, Hyperion Hotel Leipzig, 2022, Presentation
• Hofmann, S.; Weiland, C.; Fitschen, J.; v. Kameke, A.; Hoffmann, M.; Schlüter, M.: Vergleich von experimentellen und numerischen Untersuchungen zur Abschätzung des Folgevermögens verschiedener Lagrange’scher Partikel in der Bioreaktorströmung, Jahrestreffen der ProcessNet-Fachgruppen Computational Fluid Dynamics + Mischvorgänge + Agglomerations- und Schüttguttechnik, DECHEMA, Hyperion Hotel Leipzig, 2022, Presentation
• Hofmann, S.; Gaugler, L.; Fitschen, J.; v. Kameke, A.; Schlüter, M.; Takors, R.: Lagrangian Particle Tracking and Bioreactor Compartmentalization as Novel Scale-up Tools for Biopharmaceutical Processes, 13th European Congress of Chemical Engineering, 6th European Congress of Applied Biotechnology (ECCE 13 & ECAB 6), DECHEMA, Online conference, 2021, Presentation
• Fitschen, J.; Kuschel, M.; Hofmann, S.; Hoffmann, H.; von Kameke, A.; Wucherpfennig, T.; Wutz, J.; Schlüter, M.: Validation of Numerical Flow Simulations in a 3 L Stirred Tank by Means of Real 4D Particle Trajectories 13th European Congress of Chemical Engineering, 6th European Congress of Applied Biotechnology (ECCE 13 & ECAB 6), DECHEMA, Online conference, 2021, Presentation
• Fitschen, J.; Hofmann, S.; Hoffmann, H.; von Kameke, A.; Schlüter, M.: Measurement of Lagrangian Tracks in a 3 L Stirred Tank Reactor using 4D Particle Tracking Velocimetry with Shake-the-Box, ISPIV 21 (virtual), 2021, Presentation
• Fitschen, J.; Kuschel, M.; Hofmann, S.; Hoffmann, H.; von Kameke, A.; Wucherpfennig, T.; Wutz, J.; Schlüter, M.: Validierung von numerischen Strömungssimulationen in einem 3L Rührkesselreaktor mittels 3D Partikel Trajektorien, Jahrestreffen der ProcessNet-Fachgruppen Computational Fluid Dynamics und Mehrphasenströmungen, 2021, Plenary Lecture
• Hofmann, S.; Gaugler, L.: CHOLife - Multiscale Experimental Analysis and Simulation of Lifelines in Bioreactors to Study their Impact on the Cultivation Performance of CHO Cells, 2nd Annual Priority Program Status Meeting of the SPP2170 "InterZell", organized by Uni Stuttgart, Koblenz, 2021, Presentation

Poster Presentations

• Hofmann, S.: Experimental Determination of Compartments in a 15,000 L Acrylic Glass Bioreactor by Means of Lagrangian Sensor Particles, Biobased Process and Reactor Technologies PhD Seminar, Hamburg University of Technology, Hamburg, 2022, Poster Presentation

• Hofmann, S.; Buntkiel, L.; Reinecke, S.; GopalSingh, P.; Fitschen, J.; Hoffmann, M.; Hampel, U.; Schlüter, M.: Experimentelle Charakterisierung unterschiedlicher Lagrangescher Sensor Partikel Designs in einem 15000 L Bioreaktor, 16. Dresdner Sensor-Symposium, Dresden, 2022, Poster Presentation

• Hofmann, S.; Weiland, C.; GopalSingh, P.; Kamp, M.; Fitschen, J.; v. Kameke, A.; Hoffmann, M.; Schlüter, M.: Experimental and Numerical Determination of Lifelines in a 3 L, 200 L and 15000 L Stirred Tank Reactor to Estimate the Flow-Following Capability of Lagrangian Sensor Particles, FTZ 3i Talk: Conference on intelligent - industrial - innovations, HAW Hamburg 2022, Poster Presentation

• Hofmann, S.; Weiland, C.; GopalSingh, P.; Kamp, M.; Fitschen, J.; v. Kameke, A.; Hoffmann, M.; Schlüter, M.: Experimental and Numerical Determination of Lifelines in a 3 L, 200 L and 15000 L Stirred Tank Reactor to Estimate the Flow-Following Capability of Lagrangian Sensor Particles, 4th International Symposium on Multiscale Multiphase Process Engineering (MMPE), Berlin 2022, Poster Presentation

• Hofmann, S.; Weiland, C.; GopalSingh, P.; Kamp, M.; Fitschen, J.; v. Kameke, A.; Hoffmann, M.; Schlüter, M.: Experimental and numerical determination of lifelines in a 3 L, 200 L and 15000 L stirred tank reactor, MIXING XXVII, North American Mixing Forum (NAMF), Online Conference 2022, Poster Presentation

• Hofmann, S.; Fitschen, J.; v. Kameke, A.; Schlüter, M.: Multiscale Experimental Analysis of Lifelines in Bioreactors 1. Hamburg-Bochumer Mehrphasensymposium, Hamburg/Bochum, Online Conference, 2020, Poster Presentation

Marc Maly studied at Hamburg University of Technology (TUHH) from 2012 to 2015 in the bachelor's programme Energy and Environmental Engineering. Following his Bachelor Thesis, Marc Maly started working as a student assistant at the Institute of Multiphase Flows (IMS). From 2015 on he attended the master’s programme Renewable Energy at TUHH and graduated at the end of 2018.

After graduating, he started working for TuTech Innovations GmbH in 2019 and was employed at the IMS as a research assistant. There he took care of the industrial research projects of the institute until June 2024.

From November 2023 on, Marc Maly was the group leader of the working group Industrial Research Projects, which closely cooperates with the research groups Multiphase Flows in Bioreactors and Reactive Bubbly Flows at IMS.

Undergraduate and Graduate Teaching Assistant

• Grundlagen des Technischen Zeichnens (summer semester 2021)

• Konstruktion und Apparatebau (winter semester 2021/2022)

• Konstruktion und Apparatebau (winter semester 2022/2023)

• Einführung in CAD (winter semester 2023/2024)

Supervised Theses

• "Effect of a Phosphate-Buffered System on the Determination of the Volumetric Mass Transfer Coefficient k_La for CO₂", Lara Offermann, Bachelor thesis (supervision in cooperation with Sebastian Hofmann and Nicolas Nickel), 2024

• "Measurement and modelling of carbon dioxide and oxygen partial pressures over the height of a 15,000 L acrylic glass reactor", Noah von Schnitzler, Master thesis (supervision in cooperation with Nicolas Nickel and Sebastian Hofmann), 2024

• "Development, Implementation and Testing of a Technical Solution for the Determination of Gas Partial Pressures at Different Heights of an Aerated Stirred Tank Reactor on Industrial Scale", Noah von Schnitzler, project work (supervision in cooperation with Sebastian Hofmann and Nicolas Nickel), 2024

• "Bereitstellung regenerativer Energie aus Abwasserwärme zur nachhaltigen Sanierung eines Großpumpwerkes", Atousa Jalilian, Master thesis (supervision of external thesis at Hamburg Wasser, supervisors at Hamburg Wasser: B. Büttner and S. Stenbuck), 2023

• "Development of a Method for the Experimental Determination of the Circulation Gas Fraction in Jet Loop Reactors", Karolina Piernikowski, Master thesis, 2023

• "Experimental Investigation and Classification of the Mass Transfer Coefficient of Different Aeration Devices in the 3 L Stirred Tank Reactor Under Consideration of the Bubble Formation", Jannick Krause, Bachelor thesis (supervision in cooperation with Ingrid Haase), 2023

• "Experimental Investigation of the Influence of Modified Agitators on the Power Input and Oxygen Mass Transfer in a 30 Liter Stirred Tank Reactor", Josefine Velde, project work (supervision in cooperation with Ingrid Haase), 2023

• "Prototyping, Implementation and Investigation of an Additional Aerator for a Jet Loop Reactor in Form of a Flange Module", Sweta Shamria, project work, 2023

• "Implementation of a Process for the Oxidation of Biomass to Formic Acid in a Jet Loop Reactor", Malte Maßmann, Master thesis (external thesis at Universität Hamburg, supervision in cooperation with Sebastian Eller), 2023

• "Experimental Investigation and Optimisation of the Geometry of a Two-Phase Nozzle in a Jet Loop Reactor", Merle Wohlberg, Bachelor thesis, 2022

• "Study of Storage Stability in Relation to Moisture Diffusion and Temperature in Automatic Dish Washing Tablets", Srividya Bairamangala, Master thesis (supervision of external thesis at Henkel AG & Co. KGaA; supervisor at Henkel AG & Co. KGaA: A. Gebert), 2022

• "Design of a Pressure- and Chemical-Resistant Jet-Loop Reactor by Scale-Down from Pilot-Plant to Laboratory Scale and Subsequent Characterisation", Steffen Schaper, Master thesis, 2021

• "Experimental Determination of the Oxygen Mass Transfer Performance and the Bubble Size Distribution of a 200 L Single-Use Aerated Stirred Tank Reactor", Rajat Srivastava, Master thesis (supervision in cooperation with Jürgen Fitschen), 2021

• "Experimental Analysis of the Solids Discharge in a Three-Phase Operated Airlift Loop Reactor", Anna-Christin Menzel, Bachelor thesis, 2020

Committees

• Member of the Examination Committee for Process Engineering (04/2021 - 04/2023)

• Deputy member of the Examination Committee for Green Technologies/Energy and Environmental Engineering (04/2021 - 06/2024)

Supervised Student Assistants

• Timo Scherwinski, 03/2019 - 06/2019

• Anna Menzel, 10/2019 - 06/2023

• Anahita Radmehr, 03/2020 - 06/2022

• Steffen Schaper, 09/2020 - 11/2020

• Helena Ostrinsky, 07/2023 - 06/2024

• Jakob Schulze, 07/2023 - 06/2024

• Noah von Schnitzler, 10/2023 - 04/2024

• Jannick Krause, 11/2023 - 06/2024

Oral Presentations

• Maly, M.; Kuwertz, R.; Heck, J.; Schlüter, M.: Scale-Up Investigations of a Jet Loop Reactor for the Implementation of a Chemical Process in an Alternative Reactor Concept, 11th International Conference on Multiphase Flow, Kobe, Japan, 2023, oral presentation

• Maly, M.: Investigations for the Transfer and Intensification of an Agrochemical Process, PhD Student Seminar of FSP Environmental & Energy Systems, 2023, oral presentation

• Pesch, S., Radmehr, A., Knopf, R., Maly, M., Paris, C. B., Perlin, N., et al.: Investigation of Droplet Dispersion and Distribution in Experiments and Modeling: Relevant Findings for Decision-Making and Dispersant Use, Gulf of Mexico Oil Spill & Ecosystem Science Conference, Tampa, FL, 2020, oral presentation

• Pesch, S.; Maly, M.; Jaeger, P.; Malone, K.; Krause, D.; Schlüter, M.: Experimental Investigation of the Rise Behavior of Live-Oil Droplets during Deep-Sea Oil Spills, Advancing Oil Spill Research, Part 2, Webinar, Marine Technology Society (MTS), 2018, oral presentation

• Pesch, S.; Maly, M.; Jaeger, P.; Malone, K.; Krause, D.; Schlüter, M.: Experimental Investigation of the Rise Behavior of Gas-Saturated Crude-Oil Droplets under High Pressure, 6th Gulf of Mexico Oil Spill and Ecosystem Science Conference, New Orleans, LA, 2018, oral presentation

• Maly, M.; Pesch, S.; Schlüter, M.: Die Tiefsee im Labor – Wie eine Ölkatastrophe an der TUHH erforscht wird, 2. Maritime Nacht an der TUHH, Hamburg, Germany, 2018, oral presentation

Poster Presentations

• Maly, M.; Hoffmann, M.; Schlüter, M.: Experimental Analysis of the Solids Discharge in a Three-Phase Airlift Loop Reactor, 1. Hamburg-Bochumer Mehrphasensymposium, Hamburg/Bochum, online conference, 2020, poster presentation