Jürgen Fitschen, M.Sc.

Eißendorfer Str. 40, Building N, Room 1.083

Telephone +49 40 42878-2031

E-Mail: Jürgen Fitschen, M.Sc.


Research

Large Scale Bioreactors – Insight Into a Black Box

 

In any case of mammalian cell expression systems it is of vital importance to ensure ideal growth conditions. In general, to achieve high product qualities and efficiencies, a constant feed and oxygen supply and a homogeneous mixing behavior have to be guaranteed during the entire process time as well as overall upstream processes. For a reliable design and scale up a profound understanding of hydrodynamics and mass transfer is required.

At the Institute of Multiphase Flows (IMS) at the Hamburg University of Technology various studies have been performed to study the influence of different operation conditions as well as stirrer geometries on mixing efficiency, mass transfer performance and power input on laboratory (0.002 and 0.03 m3) and industrial scale (15 m3). This work gives deep insights into the hydrodynamic behavior and a characterization of an industrial scale aerated stirred tank reactor." 


Education

Graduate Teaching Assistant

  • Fluid Mechanics Process Engineering


Supervised Theses

  • "Experiemental investigation of the influence of counter-diffusion and different measuring methods on the volumetric mass transfer coefficient in aerated stirred tank reactors" (working title), Ingrid Haase, Master thesis
  • "Experiemental investigation of the local gas distribution of different stirrer configurations in a 30L aerated stirred tank reactor" (workin title), Kevin Ertelt, Bachelor thesis
  • "Experimental Determination of the Oxygen Mass Transfer Performance and the Bubble Size Distribution of a 200L Single Used Aerated Stirred Tank Reactor", Rajat Srivastava, Master thesis (supervision in cooperation with Marc Maly), 2021
  • "Desgin and Construction of a flapping foil based reactor geometry and experimental evaluation of the mixing performace of different foil geometries and stirring pattern" (working title), Jonathan Garlipp, Bachelor thesis
  • "Experimental investigation of the influence of modified Rushton turbines on power input and mass transfer performance in a 30 L stirred tank reactor", Ingrid Haase, Project work, 2020
  • "Experimental Evaluation of Scale-Up Strategies for Oxygen- and Carbondioxid mass transfer of aerated stirred tank reactors", Vathsalya Pabbathi, Project work, 2020
  • "Experimental Determination of Power Input and Mixing Performance of Various Stirrer Combinations in a Lab- and Industrial Scale Aerated Stirred Tank Reactor by use of a self-constructed and 3D printed bottom driven magnetic stirrer", Benjamin Bremecker , Bachelorthesis, 2019
  • "Visualisation of streamlines in aerated stirred tank reactors - a feasibility study for the application of 2D-PTV in industrial scale", Marcus Schewe, Bachelor thesis, 2019
  • "Experimental Determination of Shear Rate in a 3L Aerated Stirred Tank Reactor by Means of Shear Sensitive Particles", Zeynep Persin, Master thesis, 2019
  • "Experimental Determination of Power Input and Mixing Characteristics of Various Stirrer Combinations in a Lab-Scale Aerated Stirred Tank Reactor", Vincent Bernemann, Bachelor thesis, 2019
  • "Experimental Determination of Bubble Size Distributions and Oxygen Mass Transfer Performances to Evaluate Scale-Up Rules for Aerated Stirred Tank Reactor in Lab- and Pilot-Scale", Ezgi Arslanturkoglu, Master thesis, 2019
  • "Design and Construction of a 30 L Aerated Stirred Tank Reactor on a Pilot Scale and Experimental Determination of Power Input and Mixing Performance for Different Stirrer Configurations", Benjamin Cardenas, Master thesis, 2019
  • "Numerische Simulation der Mischcharakteristik eines Rührkesselreaktors im industriellen Maßstab mittels verschiedener Turbulenzmodelle", Christian Weiland, Master thesis, 2019
  • "Experimental Determination of Local Bubble Size Distributions in Aerated Stirred Tank Reactor on a Pilot Scale", Lisa Christin Watter, Project work, 2018
  • "Experimenteller Vergleich von dynamischen und stationären CO2 Stoffübergangsmessungen in begasten Rührkesselreaktoren im Labor- und Industriemaßstab", Kai Heitmann, Master thesis, 2018
  • "Experimentelle Untersuchung zum Gasgehalt begaster Rührkesselreaktoren im Industriemaßstab", Xiye Zhou, Bachelor thesis, 2018
  • "Experimental Determination of Relative Humidity in the Exhaust Gas Stream of an Industrial Scale Aerated Stirred Tank Reactor", Ezgi Arslanturkoglu, Project work, 2018

 


Oral and Poster Presentations

  • Fitschen, J.; Rosseburg, A.; Wucherpfennig, T.; Wutz, J.; Schlüter, M.: Visualization of Mxing Performance and Measurement of Power Input in Aerated Stirred Tank Reactors on a Lab and Industrial Scale, 12th European Conference of Chemical Enginnering (ECCE 2019), Florence, Italy, 2019, oral presentation 
  • Fitschen, J.; Rosseburg, A.; Wucherpfennig, T.; Wutz, J.; Schlüter, M.: Bioprocesses Made Transparent - Stirring on Industrial Scale - Deep Insights and Characterization, Jahrestreffen der ProzessNet-Fachgruppen Mischvörgänge, Trocknungstechnik und Wärme- und Stoffübertragung, Essen, 2019, oral presentation
  • Rosseburg, A., Fitschen, J., Wutz, J., Wucherpfennig, T., Schlüter, M., „Influence of local flow structure on the mixing behaviour within an aerated 12 000L stirred tank reactor”, Jahrestreffen der ProcessNet Fachgruppe Mischvorgänge, Munich 2018, poster presentation
  • Fitschen, J.; Rosseburg, A.; Wucherpfennig, T.;Wutz, J.; Schlüter, M.: Verfahren zur optischen Bestimmung von lokalen Konzentrationsgradienten in einem gläsernen 15 kL begasten Rührkesselreaktor., Gemeinsamen Jahrestreffen MPH, WSUE & CFD, Bremen, Germany, 2018, poster presentation
  • Fitschen, J.; Rosseburg, A.; Wucherpfennig, T.; Wutz, J.; Schlüter, M.: Visualization of mixing in an acrylic 12000L aerated stirred tank reactor, 10th World Congress of Chemical Engineering, Barcelona, Spain, 2017, poster presentation


Publications

2019

  • Fitschen, J.; Maly, M.; Rosseburg, A.; Wutz, J.; Wucherpfennig, T.; Schlüter, M.; (2019). Influence of Spacing of Multiple Impellers on Power Input in an Industrial?Scale Aerated Stirred Tank Reactor. Chemie Ingenieur Techni. 91 1794-1801. [Abstract] [doi] [BibTex]

2018

  • Rosseburg, A.; Fitschen, J.; Wutz, J.; Wucherpfennig, T.; Schlüter, M. (2018). Hydrodynamic inhomogeneities in large scale stirred tanks – Influence on mixing time. Chemical Engineering Science. 188 208-220. [Abstract] [doi] [www] [BibTex]