Dr.-Ing. Jürgen Fitschen

2018 - 2023        Research Fellow at the IMS

Boehringer Ingelheim Pharma GmbH & Co. KG
Bioprocess Development Biologicals

Binger Strasse 173

55216 Ingelheim am Rhein

Phone +49 7351 54-177970

Mail Dr. Jürgen Fitschen

Research Expertise

  • Large Scale Bioreactors

  • Characterization of Heterogeneities in Aerated Stirred Tank Reactors

  • Characterization of Mixing Time


Publications

[138964]
Title: Influence of Spacing of Multiple Impellers on Power Input in an Industrial-Scale Aerated Stirred Tank Reactor.
Written by: Fitschen, J.; Maly, M.; Rosseburg, A.; Wutz, J.; Wucherpfennig, T.; Schlüter, M.;
in: <em>Chemie Ingenieur Technik</em>. (2019).
Volume: <strong>91</strong>. Number:
on pages: 1794-1801
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DOI: https://doi.org/10.1002/cite.201900121
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Abstract: Despite the fact that aerated stirred tank reactors are widely used in industry and often studied, their design and scale-up still remains challenging. Especially the specific power input is a crucial and geometry-dependent scale-up parameter, usually calculated with the dimensionless power number Po. Within the scope of this study, the power number is measured for different stirrer types and configurations in a laboratory and an industrial-scale aerated stirred tank reactor. Good agreements to literature are found for the unaerated case for the two-stage stirrer configurations at different stirrer spacing for both scales. By literature only the aerated case in the laboratory scale can be predicted. Scale-up of an aerated industrial-scale reactor is challenging because of a specific influence of the aeration. In case of a three-stage Rushton configuration, an asymmetrical distribution of the stirrers should be preferred to ensure a high power number as well as good power performance under aerated conditions.