In the open access paper the authors stated that in response to climate and market pressures, in biotechnology replacing traditional stirred tank reactors with biofilm-based systems should be considered. These systems offer advantages such as higher biomass density, improved genetic stability and the potential for enhanced productivity. However, challenges such as controlling fluid dynamics and achieving sufficient biofilm densities and substratum coverage remain. While conventional systems currently dominate, biofilm reactors offer a promising way forward for innovative, efficient, and sustainable bioproduction.
Mandel, C., M. Edel, and J. Gescher (2025). Opinion on Biofilms as Production Systems. Microbial Biotechnology 18 (6), e70182.
