PD Dr. habil. Monika Johannsen

Eißendorfer Str. 38

21073 Hamburg

Building O, Room 1.012

Phone +49 40 42878 - 4260

Mail PD Dr. habil. Monika Johannsen


  • Chromatographic Separation Processes (Module "Separation Technologies for Life Science")
  • Advanced Separation Processes (Module "High Pressure Chemical Engineering")


Title: Simulated moving bed chromatography with supercritical fluids for the resolution of bi-naphthol enantiomers and phytol isomers.
Written by: Johannsen, M., Peper, S., Depta, A.
in: <em>Simulated moving bed chromatography with supercritical fluids for the resolution of bi-naphthol enantiomers and phytol isomers</em>. (2002).
Volume: <strong>54 (1-3)</strong>. Number:
on pages: 54 (1-3)
Publisher: Elsevier B.V.:
how published:
Institution: Institute of Thermal Separation Processes, Hamburg University of Technology, Eißendorfer Straße 38, 21073 Hamburg, Germany
DOI: 10.1016/S0165 022X(02)00132-X
URL: https://www.sciencedirect.com/science/article/pii/S0165022X0200132X



Abstract: The combination of the simulated moving bed (SMB) technique with supercritical fluid chromatography (SFC) leads to a process with unique features. Besides the known advantages of the SMB process, the use of supercritical carbon dioxide as the mobile phase offers the advantages of reduction in organic solvents and an easy eluent/solute separation. Because of the low viscosity and high diffusion coefficients of supercritical fluids, a high efficiency is possible. The steps of process development for SMB SFC are presented using the separations of the bi-naphthol enantiomers and phytol isomers as examples. The development of a packed column SFC method at an analytical scale is shown for the separation of the bi-naphthol enantiomers on a chiral stationary phase and CO2 with a modifier as the mobile phase. The influence of the modifier, modifier content, and column configuration on productivity of the SMB SFC process was investigated by simulation. The first set of experiments was performed in the SMB separation of phytol isomers at low concentration to test the feasibility of the SMB SFC high purity separation of the binary mixtures. In the second set of experiments, the productivity of the process was increased by increasing the feed concentration up to 54 grams feed per liter stationary phase (SP) and hour (gfeed/lSP h).

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