PD Dr. habil. Monika Johannsen


Eißendorfer Str. 38

21073 Hamburg

Building O, Room 1.012

Phone +49 40 42878 - 4260

Mail PD Dr. habil. Monika Johannsen


Education

  • Chromatographic Separation Processes (Module "Separation Technologies for Life Science")
  • Advanced Separation Processes (Module "High Pressure Chemical Engineering")

Publications

[156156]
Title: Enantioseparation of 1-phenyl-1-propanol by supercritical fluid-simulated moving bed chromatography.
Written by: Rajendran, A., Peper, S., Johannsen, M., Mazzotti, M., Morbidelli, M., Brunner, G.
in: <em>Journal of Chromatography A</em>. (2005).
Volume: <strong>1092 (1)</strong>. Number:
on pages: 55-64
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Publisher: Elsevier B.V.:
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Institution: Institute of Thermal Separation Processes, Hamburg University of Technology, Eißendorfer Straße 38, 21073 Hamburg, Germany
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DOI: 10.1016/j.chroma.2005.02.040
URL: https://www.sciencedirect.com/science/article/abs/pii/S0021967305002827
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Abstract: The enantioseparation of 1-phenyl-1-propanol through the supercritical fluid-simulated moving bed (SF-SMB) process is studied. Non-linear isotherms were measured on an analytical column, and used together with the triangle theory for SMB design to select operating conditions for the SF-SMB. Experiments were carried out on a pilot-scale SF-SMB plant at conditions that corresponded to the non-linear range of the isotherm. Under conditions of low feed concentration, complete separation (extract purity?=?99.5%; raffinate purity?=?98.4%) was achieved. Under conditions of larger feed concentration, the best separation corresponded to an extract purity of 98.0% and a raffinate purity of 94.0%, and yielded a productivity of 110?g of racemate per kg stationary phase per day.

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