PD Dr. habil. Monika Johannsen

Eißendorfer Str. 38

21073 Hamburg

Building O, Room 1.012

Phone +49 40 42878 - 4260

Mail PD Dr. habil. Monika Johannsen


  • Chromatographic Separation Processes (Module "Separation Technologies for Life Science")
  • Advanced Separation Processes (Module "High Pressure Chemical Engineering")
Title: Adsorption equilibria of benzoic acid on silica gel from supercritical carbon dioxide.
Written by: Pérez Molina, B.C., Johannsen, M.
in: <em>The Journal of Supercritical Fluids</em>. (2010).
Volume: <strong>54</strong>. Number:
on pages: 237-242
Publisher: Elsevier B.V.:
how published:
Institution: Hamburg University of Technology, Eissendorfer Strasse 38, D-21073 Hamburg, Germany
DOI: https://doi.org/10.1016/j.supflu.2010.05.015
URL: https://www.sciencedirect.com/science/article/pii/S0896844610001968



Abstract: Supercritical fluids, especially carbon dioxide, are increasingly used as carriers for adsorption–desorption processes, particularly in the pharmaceutical industry. Nevertheless, equilibria data for such processes are rather limited. Therefore, in this work, the adsorption equilibria of benzoic acid onto non-modified silica gel from scCO2 were evaluated by Supercritical Fluid Chromatography applying the Peak Maxima method. Solubility of benzoic acid in scCO2 was enhanced by addition of 2-propanol. The effects of modifier content, temperature and pressure on the solute loading were investigated. Experimental data were best described by the cubic Hill isotherm model, which accounted for the change of curvature of the elution profiles observed as concentrations in the mobile phase increased. For the concentration range reached in this study (up to 6 mg/mL), adsorption of benzoic acid was favoured at low modifier contents, high temperatures and low pressures, conditions at which the solvating power of the modified scCO2 decreased.

Read more

Hier ist der ausgeblendete Text, der angezeigt wird, wenn der Knopf gedrückt wird.