Current Research Projects

On this website you will find an overview of all research areas and research projects at the Institute of Multiphase Flows.


Turbulent Reactive Flows

Experimental Investigation of Reactive Bubbly Flows

How does the interaction of the timescales of hydrodynamic mixing, mass transfer and reaction influence the selectivity in a chemical process?

Using laser measuring techniques like Particle Image Velocimetry and Laser Induced Fluoresccence to visualize the velocity and concentration fields of reactants, product or side products to understand the interaction of their timescales.

The understanding of the inerlinked local processes can lead to more save, reliable and efficient process control in mulitphase reactors of the next generation.

Detailed Information can be found here.

2D Turbulence in Faraday Flows

The energy transfer process in quasi-2D turbulent flows that develop on the surface of Faraday waves is investigated with laser techniques such as Particle Image Velocimetry and Particle Tracking Velocimetry.

Additionally, the interactions of the surface layer with the flow beneath the surface are studied: how does the vertical movement of the waves generate vorticity in the horizontal plane? What kind of velocity profiles and flow structures develop below the surface?"

Detailed Information can be found here.

CFD & Multiphase Mixing

Hydrodynamic Characterization of Deep-Sea Blowouts

For the experimental investigation of multiphase flow phenomena under simulated deep-sea conditions several high-pressure facilities have been developed, built and commissioned.

Sophisticated measurement technologies such as high-definition camera recording, high-speed Particle Image Velocimetry (PIV) and an endoscopic particle size measurement system from the Sopat GmbH are applied.

Close collaboration with various international partners for experimental investigations and modeling.

Detailed Information can be found here.

KoPPona 2.0

Driven by the ENPRO initiative the fine and special chemistry industry develops continuous processes with special requirements to versatility, robustness and service life to efficiently produce polymer specialties. Modular micro and mini structured plants provide a suitable solution and ensure efficient reaction control and enable scale up while minimizing operating cost. Fouling in micro structured devices decreases the service time and is therefore investigated by the KoPPonA 2.0 project.

Mass transfer in micro structured devices, polymerization reaction networks and polymer accretion on reactor walls are numerically modeled in CFD. For the model validation microscopic laser-induced fluorescence (µ-LIF) and UV/VIS are applied. Analytic chemistry and sensor technology is embraced with close collaboration of project partners.

Detailed Information can be found here.

Multiphase Bioreactors

Large Scale Bioreactors - Insights Into a Black Box

Lack of knowledge especially for large scale applications, where the influence of the inhomogeneity of the gas phase is much higher than in small scale reactors.

An acrylic glass reactor has been designed and erected on industrial scale (15 000 L).

The optical access of this reactor enables us detailed studies on local flow patterns and their influences on mixing and mass transfer.

Liquids with tailored theology for the substiution of process media to enable opticale measurements (various industrial partners).

Detailed Information can be found here.

Characterization of Fine Bubbles for Biocatalytic Processes

Macroscopic aeration can lead to reduced enzyme activity by foaming and induced shear forces.

Bubbles with diameters less than 100 μm offer large volume-specific interfacial areas a and therefore high mass transfer rates βLa of the gaseous reactant into the bulk phase.

The project is in close collaboration with the Institute of Technical Biocatalysis (ITB) focusing on the application of the achieved findings for biocatalytic processes.

Detailed Information can be found here.

Protein Pressure Specific Activity Impact (Prot P.S.I.)

Within the framework of the research alliance Prot P.S.I., the influence and utilization of the parameter pressure on enzymatically catalyzed reactions is being investigated in more detail.

The aim of subproject B1, to which the Institute of Multiphase Flows also belongs, is to develop a reactor design for oxygen-consuming reactions and to investigate corresponding measurement systems up to pressures of 150 bar.

The focus of the reactor design is particularly on minimizing enzyme-damaging shear forces, which occur in particular during aeration.

Detailed Information can be found here.


InterZell is contributing to sustainable production pathways by combining engineering and natural sciences.

The sub-project "CHOLife" tackles the scale-up problem for protein production by CHO (Chinese Hamster Ovary) cells. Gradients of dissolved gases, substrates and pH are typical issues in suspension cultures with the size of 12,000 – 20,000 L, to be seen and described as compartment build-up. Three dimensional flow trajectories and lifelines will be measured and evaluated for an improved way of fermentation.

Detailed Information can be found here.

Smart Reactors

New Reactor Technologies for Chemical and Biochemical Synthesis Processes

In this collaborative research project the competences of various departments based in the Hamburg Metropolitan Region are pooled.

The aim of this collaboration is the knowledge-based development, characterization and application of new reactor technologies in complex multiphase systems by modern in situ spectroscopy and imaging techniques, as well as mathematical modeling.

Our subproject is about the design, characterization and optimization of 3D printed periodic open-cell structures (POCS).

POCS serve to tailor residence time distributions, catalytic reaction surfaces, and exchange processes of multiphase flows close to the boundary layer to the process.

Detailed Information can be found here.

I³-Lab Smart Reactors

The enormous demands on modern production processes require a radical rethinking in the design and operation of reactors for biotechnology, pharmacy and chemistry.

Reactors of the future have to be "smart", i.e. quickly and flexibly adaptable to changing raw material qualities, energy sources and individual demands.

The goal of this collaborative I3 Lab is a knowledge-based design of "smart reactors", which enable significantly higher yields in chemical and biochemical reactions through an optimal reaction environment.

Fast and non-invasive measurement techniques with high resolution, data-driven validated cross-scale models and simulation methods, intelligent control mechanisms, and new, intelligently structured reactors will be developed.

Detailed Information can be found here.