Biodegradable magnesium implants

Metallic biomedical implants such as screws and plates are used to support damaged biological tissue such as fractured bone until it has regained its natural strength by healing. After healing, the currently frequently used titantium implants either remain in the body permanently - which may results undesired interactions with surrounding living tissue - or have to be removed by a second surgery - which is associated with health risks and costs. To overcome this dilemma, biodegradable implants have attracted rapidly increasing attention over the last decade. As healing progresses they slowly dissolve, leaving ideally in the end intact and perturbation-free tissue. The manufacturing and clinical application of such biodegradable implants is at the moment in its infancy. To accelerate the development of new and better magnesium alloys for such implants, we are developing in collaboration with the Institute for Metallic Biomaterials at Helmholtz-Zentrum Geesthacht a so-called digital twin of biodegradable magnesium screws. This digital twin covers all the steps from the production of the implant by sintering to the degradation under clinical conditions. Thereby it enables a fast and cheap computer-based development of improved biodebradable magnesium alloys.