Surveillance MPI Scanner for Stroke Detection on the Intensive Care Stroke Unit

Scientists at the Technical University of Hamburg (TUHH) and the University Hospital Hamburg-Eppendorf (UKE) have developed a new diagnostic tomographic imaging system that enables access to cerebral blood flow at short intervals and thus quickly indicates a possible stroke. The study "Human-sized Magnetic Particle Imaging for Brain Applications" was published on the 26th of April 2019 in the renowned journal Nature Communications.

On the road to full real-time 3D imaging using approved clinical tracers, the MPI scanner has been extensively upgraded from 2019 to 2023. Several publications document the process and highlight the development of new components, like the study "Heat it up: Thermal stabilization by active heating to reduce impedance drifts in capacitive matched networks", "Gradient power reducing using pulsed selection-field sequences" or "Resonant inductive coupling network for human-sized magnetic particle imaging". A thorough exploration is presented in "System characterization of a human-sized 3D real-time magnetic particle imaging scanner for cerebral applications".

Prof. Tobias Knopp and Dr. Matthias Gräser with the surveillance imager

Project Publications

[191084]
Title: Resonant Inductive Coupling Network for Human-Sized Magnetic Particle Imaging.
Written by: F. Mohn, F. Förger, F. Thieben, M. Möddel, I. Schmale, T. Knopp and M. Graeser
in: <em>Review of Scientific Instruments</em>. (2024).
Volume: <strong>95</strong>. Number: (4),
on pages: 044701
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DOI: 10.1063/5.0192784
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Note: article, openaccess, brainimager

Abstract: In magnetic particle imaging, a field-free region is maneuvered throughout the field of view using a time-varying magnetic field known as the drive-field. Human-sized systems operate the drive-field in the kHz range and generate it by utilizing strong currents that can rise to the kA range within a coil called the drive field generator. Matching and tuning between a power amplifier, a band-pass filter, and the drive-field generator is required. Here, for reasons of safety in future human scanners, a symmetrical topology and a transformer called an inductive coupling network are used. Our primary objectives are to achieve floating potentials to ensure patient safety while attaining high linearity and high gain for the resonant transformer. We present a novel systematic approach to the design of a loss-optimized resonant toroid with a D-shaped cross section, employing segmentation to adjust the inductance-to-resistance ratio while maintaining a constant quality factor. Simultaneously, we derive a specific matching condition for a symmetric transmit--receive circuit for magnetic particle imaging. The chosen setup filters the fundamental frequency and allows simultaneous signal transmission and reception. In addition, the decoupling of multiple drive field channels is discussed, and the primary side of the transformer is evaluated for maximum coupling and minimum stray field. Two prototypes were constructed, measured, decoupled, and compared to the derived theory and method-of-moment based simulations.