Surveillance MPI Scanner for Stroke Detection on the Intensive Care Stroke Unit

Scientists at the Technical University of Hamburg (TUHH) and the University Hospital Hamburg-Eppendorf (UKE) have developed a new diagnostic tomographic imaging system that enables access to cerebral blood flow at short intervals and thus quickly indicates a possible stroke. The study "Human-sized Magnetic Particle Imaging for Brain Applications" was published on the 26th of April 2019 in the renowned journal Nature Communications.

On the road to full real-time 3D imaging using approved clinical tracers, the MPI scanner has been extensively upgraded from 2019 to 2023. Several publications document the process and highlight the development of new components, like the study "Heat it up: Thermal stabilization by active heating to reduce impedance drifts in capacitive matched networks", "Gradient power reducing using pulsed selection-field sequences" or "Resonant inductive coupling network for human-sized magnetic particle imaging". A thorough exploration is presented in "System characterization of a human-sized 3D real-time magnetic particle imaging scanner for cerebral applications".

Prof. Tobias Knopp and Dr. Matthias Gräser with the surveillance imager

Project Publications

  • F. Mohn, F. Förger, F. Thieben, M. Möddel, I. Schmale, T. Knopp and M. Graeser (2024). Resonant Inductive Coupling Network for Human-Sized Magnetic Particle Imaging. Review of Scientific Instruments. 95. (4), 044701 [Abstract] [doi]

  • F. Thieben, F. Foerger, F. Mohn, N. Hackelberg, M. Boberg, J.-P. Scheel, Möddel, M. Graeser, and T. Knopp (2024). System Characterization of a Human-Sized 3D Real-Time Magnetic Particle Imaging Scanner for Cerebral Applications. Communications Engineering. 3. (1), 47 [Abstract] [doi]

  • F. Thieben, F. Mohn, F. Foerger, N. Hackelberg, J.-P. Scheel, M. Graeser, and T. Knopp (2023). Safe and Rapid 3D Imaging: Upgrade of a Human-Sized Brain MPI System. 9.(1). [Abstract] [doi] [www]

  • F. Thieben, F. Foerger, F. Mohn, F. Sevecke, T. Knopp, and M. Graeser (2022). Heat it up: Thermal stabilization by active heating to reduce impedance drifts in capacitive matched networks. International Journal on Magnetic Particle Imaging. 8. (1), 1-3 [Abstract] [doi] [www]

  • N. Hackelberg, J. Schumacher, M. Graeser, and T. Knopp (2022). A Flexible High-Performance Signal Generation and Digitization Plattform based on Low-Cost Hardware. International Journal on Magnetic Particle Imaging. 8. (1), 1-4 [Abstract] [doi] [www]

  • F. Thieben, M. Boberg, P. Szwargulski, M. Graeser, and T. Knopp (2020). Gradient power reducing using pulsed selection-field sequences. International Journal on Magnetic Particle Imaging. 6. (2), 1-3 [Abstract] [doi] [www]

  • F. Thieben, M. Graeser, M. Boberg, P. Szwargulski, M. Möddel, and T. Knopp (2019). Determining the Relation between Iron Mass and Spatial Resolution for a Human-Sized Magnetic Particle Brain Imager. 9th International Workshop on Magnetic Particle Imaging (IWMPI 2019) 41-42 [Abstract]

  • F. Werner, M. Gräser, F. Thieben, P Szwargulski, N. Gdaniec, M. Boberg, F. Griese, M. Möddel, P. Ludewig, D. van de Ven, O. M. Weber, O. Woywode, B. Gleich, and T. Knopp (2019). Stroke Detection using Magnetic Particle Imaging: A Phantom Study using a Human-sized Brain Phantom. 9th International Workshop on Magnetic Particle Imaging (IWMPI 2019) 141-142 [Abstract]

  • M. Graeser, F. Thieben, P. Szwargulski, F. Werner, N. Gdaniec, M. Boberg, F. Griese, M. Möddel, P. Ludewig, D. van de Ven, O. M. Weber, O. Woywode, B. Gleich, and T. Knopp (2019). First human-sized Magnetic Particle Imaging Device for Cerebral Applications. 9th International Workshop on Magnetic Particle Imaging (IWMPI 2019) 15-16 [Abstract]

  • M. Graeser, F. Thieben, P. Szwargulski, F. Werner, N. Gdaniec, M. Boberg, F. Griese, M. Möddel, P. Ludewig, D. van de Ven, O.M. Weber, O. Woywode, B. Gleich, and T. Knopp (2019). Human-sized Magnetic Particle Imaging for Brain Applications. Nature Communications. 10. (1936), 1-9 [Abstract] [doi] [www]

  • N. Gdaniec, M. Graeser, F. Thieben, P Szwargulski, F. Werner, M. Boberg, F. Griese, M. Möddel, P. Ludewig, D. van de Ven, O. M. Weber, O. Woywode, B. Gleich, and T. Knopp (2019). Determining Perfusion Parameters using Magnetic Particle Imaging: A Phantom Study using a Human-Sized Flow Phantom. 9th International Workshop on Magnetic Particle Imaging (IWMPI 2019) 151-152 [Abstract]

  • P. Szwargulski, M. Graeser, F. Thieben, N. Gdaniec, F. Werner, M. Boberg, F. Griese, M. Möddel, and T. Knopp (2019). Interpretation of Cartesian Data based on a Simulated Human-Sized MPI Brain Imager. 9th International Workshop on Magnetic Particle Imaging (IWMPI 2019) 37-38 [Abstract]