Current Publications

Journal Publications
since 2022

Recent Journal Publications

[145080]
Title: Optimization of magnetic nanoparticles for engineering erythrocytes as theranostic agents.
Written by: L. M. Slavu, A. Antonelli, E.S. Scarpa, P. Abdalla, C. Wilhelm, N. Silvestri, T. Pellegrino, K. Scheffler, M. Magnani, R. Rinaldi, R. Di Corato
in: <em>Biomater. Sci.</em>. March (2023).
Volume: Number:
on pages:
Chapter:
Editor:
Publisher: The Royal Society of Chemistry:
Series:
Address:
Edition:
ISBN:
how published:
Organization:
School:
Institution:
Type:
DOI: 10.1039/D3BM00264K
URL: http://dx.doi.org/10.1039/D3BM00264K
ARXIVID:
PMID:

[www] [BibTex]

Note: article

Abstract: The application of superparamagnetic iron oxide nanoparticles (SPIONs) in drug delivery{,} magnetic resonance imaging{,} cell tracking{,} and hyperthermia has been long exploited regarding their inducible magnetic properties. Nevertheless{,} SPIONs remain rapidly cleared from the circulation by the reticuloendothelial system (RES) or mononuclear phagocyte system{,} with uptake dependent on several factors such as the hydrodynamic diameter{,} electrical charge and surface coating. This rapid clearance of SPION-based theranostic agents from circulation is one of the main challenges hampering the medical applications that differ from RES targeting. This work proposes a strategy to render biocompatible SPIONs through their encapsulation in the red blood cells (RBCs). In this work{,} the research has been focused on the multi-step optimization of chemical synthesis of magnetic nanoparticles (MNPs){,} precisely iron oxide nanoparticles (IONPs) and zinc manganese-ferrite nanoparticles (Zn/Mn FNPs){,} for encapsulation in human and murine RBCs. The encapsulation through the transient opening of RBC membrane pores requires extensive efforts to deliver high-quality nanoparticles in terms of chemical properties{,} morphology{,} stability and biocompatibility. After reaching this goal{,} in vitro experiments were performed with selected nanomaterials to investigate the potential of engineered MNP-RBC constructs in theranostic approaches.

Conference Abstracts and Proceedings
since 2022

Recent Conference Abstracts and Proceedings

[145080]
Title: Optimization of magnetic nanoparticles for engineering erythrocytes as theranostic agents.
Written by: L. M. Slavu, A. Antonelli, E.S. Scarpa, P. Abdalla, C. Wilhelm, N. Silvestri, T. Pellegrino, K. Scheffler, M. Magnani, R. Rinaldi, R. Di Corato
in: <em>Biomater. Sci.</em>. March (2023).
Volume: Number:
on pages:
Chapter:
Editor:
Publisher: The Royal Society of Chemistry:
Series:
Address:
Edition:
ISBN:
how published:
Organization:
School:
Institution:
Type:
DOI: 10.1039/D3BM00264K
URL: http://dx.doi.org/10.1039/D3BM00264K
ARXIVID:
PMID:

[www]

Note: article

Abstract: The application of superparamagnetic iron oxide nanoparticles (SPIONs) in drug delivery{,} magnetic resonance imaging{,} cell tracking{,} and hyperthermia has been long exploited regarding their inducible magnetic properties. Nevertheless{,} SPIONs remain rapidly cleared from the circulation by the reticuloendothelial system (RES) or mononuclear phagocyte system{,} with uptake dependent on several factors such as the hydrodynamic diameter{,} electrical charge and surface coating. This rapid clearance of SPION-based theranostic agents from circulation is one of the main challenges hampering the medical applications that differ from RES targeting. This work proposes a strategy to render biocompatible SPIONs through their encapsulation in the red blood cells (RBCs). In this work{,} the research has been focused on the multi-step optimization of chemical synthesis of magnetic nanoparticles (MNPs){,} precisely iron oxide nanoparticles (IONPs) and zinc manganese-ferrite nanoparticles (Zn/Mn FNPs){,} for encapsulation in human and murine RBCs. The encapsulation through the transient opening of RBC membrane pores requires extensive efforts to deliver high-quality nanoparticles in terms of chemical properties{,} morphology{,} stability and biocompatibility. After reaching this goal{,} in vitro experiments were performed with selected nanomaterials to investigate the potential of engineered MNP-RBC constructs in theranostic approaches.

Publications

Journal Publications
since 2014

Journal Publications

[145080]
Title: Optimization of magnetic nanoparticles for engineering erythrocytes as theranostic agents.
Written by: L. M. Slavu, A. Antonelli, E.S. Scarpa, P. Abdalla, C. Wilhelm, N. Silvestri, T. Pellegrino, K. Scheffler, M. Magnani, R. Rinaldi, R. Di Corato
in: <em>Biomater. Sci.</em>. March (2023).
Volume: Number:
on pages:
Chapter:
Editor:
Publisher: The Royal Society of Chemistry:
Series:
Address:
Edition:
ISBN:
how published:
Organization:
School:
Institution:
Type:
DOI: 10.1039/D3BM00264K
URL: http://dx.doi.org/10.1039/D3BM00264K
ARXIVID:
PMID:

[www] [BibTex]

Note: article

Abstract: The application of superparamagnetic iron oxide nanoparticles (SPIONs) in drug delivery{,} magnetic resonance imaging{,} cell tracking{,} and hyperthermia has been long exploited regarding their inducible magnetic properties. Nevertheless{,} SPIONs remain rapidly cleared from the circulation by the reticuloendothelial system (RES) or mononuclear phagocyte system{,} with uptake dependent on several factors such as the hydrodynamic diameter{,} electrical charge and surface coating. This rapid clearance of SPION-based theranostic agents from circulation is one of the main challenges hampering the medical applications that differ from RES targeting. This work proposes a strategy to render biocompatible SPIONs through their encapsulation in the red blood cells (RBCs). In this work{,} the research has been focused on the multi-step optimization of chemical synthesis of magnetic nanoparticles (MNPs){,} precisely iron oxide nanoparticles (IONPs) and zinc manganese-ferrite nanoparticles (Zn/Mn FNPs){,} for encapsulation in human and murine RBCs. The encapsulation through the transient opening of RBC membrane pores requires extensive efforts to deliver high-quality nanoparticles in terms of chemical properties{,} morphology{,} stability and biocompatibility. After reaching this goal{,} in vitro experiments were performed with selected nanomaterials to investigate the potential of engineered MNP-RBC constructs in theranostic approaches.

Conference Abstracts and Proceedings
since 2014

Conference Abstracts and Proceedings

[145080]
Title: Optimization of magnetic nanoparticles for engineering erythrocytes as theranostic agents.
Written by: L. M. Slavu, A. Antonelli, E.S. Scarpa, P. Abdalla, C. Wilhelm, N. Silvestri, T. Pellegrino, K. Scheffler, M. Magnani, R. Rinaldi, R. Di Corato
in: <em>Biomater. Sci.</em>. March (2023).
Volume: Number:
on pages:
Chapter:
Editor:
Publisher: The Royal Society of Chemistry:
Series:
Address:
Edition:
ISBN:
how published:
Organization:
School:
Institution:
Type:
DOI: 10.1039/D3BM00264K
URL: http://dx.doi.org/10.1039/D3BM00264K
ARXIVID:
PMID:

[www]

Note: article

Abstract: The application of superparamagnetic iron oxide nanoparticles (SPIONs) in drug delivery{,} magnetic resonance imaging{,} cell tracking{,} and hyperthermia has been long exploited regarding their inducible magnetic properties. Nevertheless{,} SPIONs remain rapidly cleared from the circulation by the reticuloendothelial system (RES) or mononuclear phagocyte system{,} with uptake dependent on several factors such as the hydrodynamic diameter{,} electrical charge and surface coating. This rapid clearance of SPION-based theranostic agents from circulation is one of the main challenges hampering the medical applications that differ from RES targeting. This work proposes a strategy to render biocompatible SPIONs through their encapsulation in the red blood cells (RBCs). In this work{,} the research has been focused on the multi-step optimization of chemical synthesis of magnetic nanoparticles (MNPs){,} precisely iron oxide nanoparticles (IONPs) and zinc manganese-ferrite nanoparticles (Zn/Mn FNPs){,} for encapsulation in human and murine RBCs. The encapsulation through the transient opening of RBC membrane pores requires extensive efforts to deliver high-quality nanoparticles in terms of chemical properties{,} morphology{,} stability and biocompatibility. After reaching this goal{,} in vitro experiments were performed with selected nanomaterials to investigate the potential of engineered MNP-RBC constructs in theranostic approaches.

Publications Pre-dating the Institute

Publications
2007-2013

Old Publications

[145080]
Title: Optimization of magnetic nanoparticles for engineering erythrocytes as theranostic agents.
Written by: L. M. Slavu, A. Antonelli, E.S. Scarpa, P. Abdalla, C. Wilhelm, N. Silvestri, T. Pellegrino, K. Scheffler, M. Magnani, R. Rinaldi, R. Di Corato
in: <em>Biomater. Sci.</em>. March (2023).
Volume: Number:
on pages:
Chapter:
Editor:
Publisher: The Royal Society of Chemistry:
Series:
Address:
Edition:
ISBN:
how published:
Organization:
School:
Institution:
Type:
DOI: 10.1039/D3BM00264K
URL: http://dx.doi.org/10.1039/D3BM00264K
ARXIVID:
PMID:

[www]

Note: article

Abstract: The application of superparamagnetic iron oxide nanoparticles (SPIONs) in drug delivery{,} magnetic resonance imaging{,} cell tracking{,} and hyperthermia has been long exploited regarding their inducible magnetic properties. Nevertheless{,} SPIONs remain rapidly cleared from the circulation by the reticuloendothelial system (RES) or mononuclear phagocyte system{,} with uptake dependent on several factors such as the hydrodynamic diameter{,} electrical charge and surface coating. This rapid clearance of SPION-based theranostic agents from circulation is one of the main challenges hampering the medical applications that differ from RES targeting. This work proposes a strategy to render biocompatible SPIONs through their encapsulation in the red blood cells (RBCs). In this work{,} the research has been focused on the multi-step optimization of chemical synthesis of magnetic nanoparticles (MNPs){,} precisely iron oxide nanoparticles (IONPs) and zinc manganese-ferrite nanoparticles (Zn/Mn FNPs){,} for encapsulation in human and murine RBCs. The encapsulation through the transient opening of RBC membrane pores requires extensive efforts to deliver high-quality nanoparticles in terms of chemical properties{,} morphology{,} stability and biocompatibility. After reaching this goal{,} in vitro experiments were performed with selected nanomaterials to investigate the potential of engineered MNP-RBC constructs in theranostic approaches.

Open Access Publications

Journal Publications
since 2014

Open Access Publications

[145080]
Title: Optimization of magnetic nanoparticles for engineering erythrocytes as theranostic agents.
Written by: L. M. Slavu, A. Antonelli, E.S. Scarpa, P. Abdalla, C. Wilhelm, N. Silvestri, T. Pellegrino, K. Scheffler, M. Magnani, R. Rinaldi, R. Di Corato
in: <em>Biomater. Sci.</em>. March (2023).
Volume: Number:
on pages:
Chapter:
Editor:
Publisher: The Royal Society of Chemistry:
Series:
Address:
Edition:
ISBN:
how published:
Organization:
School:
Institution:
Type:
DOI: 10.1039/D3BM00264K
URL: http://dx.doi.org/10.1039/D3BM00264K
ARXIVID:
PMID:

[www] [BibTex]

Note: article

Abstract: The application of superparamagnetic iron oxide nanoparticles (SPIONs) in drug delivery{,} magnetic resonance imaging{,} cell tracking{,} and hyperthermia has been long exploited regarding their inducible magnetic properties. Nevertheless{,} SPIONs remain rapidly cleared from the circulation by the reticuloendothelial system (RES) or mononuclear phagocyte system{,} with uptake dependent on several factors such as the hydrodynamic diameter{,} electrical charge and surface coating. This rapid clearance of SPION-based theranostic agents from circulation is one of the main challenges hampering the medical applications that differ from RES targeting. This work proposes a strategy to render biocompatible SPIONs through their encapsulation in the red blood cells (RBCs). In this work{,} the research has been focused on the multi-step optimization of chemical synthesis of magnetic nanoparticles (MNPs){,} precisely iron oxide nanoparticles (IONPs) and zinc manganese-ferrite nanoparticles (Zn/Mn FNPs){,} for encapsulation in human and murine RBCs. The encapsulation through the transient opening of RBC membrane pores requires extensive efforts to deliver high-quality nanoparticles in terms of chemical properties{,} morphology{,} stability and biocompatibility. After reaching this goal{,} in vitro experiments were performed with selected nanomaterials to investigate the potential of engineered MNP-RBC constructs in theranostic approaches.