Prof. Dr.-Ing. Tobias Knopp

Universitätsklinikum Hamburg-Eppendorf (UKE)
Sektion für Biomedizinische Bildgebung
Lottestraße 55
2ter Stock, Raum 209
22529 Hamburg
- Postanschrift -

Technische Universität Hamburg (TUHH)
Institut für Biomedizinische Bildgebung
Gebäude E, Raum 4.044
Am Schwarzenberg-Campus 3
21073 Hamburg

Tel.: 040 / 7410 56794
Fax: 040 / 7410 45811
E-Mail: t.knopp(at)
E-Mail: tobias.knopp(at)



  • Head of the Institute for Biomedical Imaging
  • Editor-in-chief of the International Journal on Magnetic Particle Imaging (IJMPI)

Consulting Hours

  • On appointment

Research Interests

  • Tomographic Imaging
  • Image Reconstruction
  • Signal- and Image Processing
  • Magnetic Particle Imaging

Curriculum Vitae

Tobias Knopp received his Diplom degree in computer science in 2007 and his PhD in 2010, both from the University of Lübeck with highest distinction. For his PHD on the tomographic imaging method Magnetic Particle Imaging (MPI) he was awarded with the Klee award from the DGBMT (VDE) in 2011. From 2010 until 2011 he led the MAPIT project at the University of Lübeck and published the first scientific book on MPI. In 2011 he joined Bruker Biospin to work on the first commercially available MPI system. From 2012 until 2014 he worked at Thorlabs in the field of Optical Coherence Tomography (OCT) as a software developer. In 2014 he has been appointed as Professor for experimental Biomedical Imaging at the University Medical Center Hamburg-Eppendorf and the Hamburg University of Technology.


Title: Optimization of magnetic nanoparticles for engineering erythrocytes as theranostic agents.
Written by: L. M. Slavu, A. Antonelli, E.S. Scarpa, P. Abdalla, C. Wilhelm, N. Silvestri, T. Pellegrino, K. Scheffler, M. Magnani, R. Rinaldi, R. Di Corato
in: <em>Biomater. Sci.</em>. March (2023).
Volume: Number:
on pages:
Publisher: The Royal Society of Chemistry:
how published:
DOI: 10.1039/D3BM00264K


Note: article

Abstract: The application of superparamagnetic iron oxide nanoparticles (SPIONs) in drug delivery{,} magnetic resonance imaging{,} cell tracking{,} and hyperthermia has been long exploited regarding their inducible magnetic properties. Nevertheless{,} SPIONs remain rapidly cleared from the circulation by the reticuloendothelial system (RES) or mononuclear phagocyte system{,} with uptake dependent on several factors such as the hydrodynamic diameter{,} electrical charge and surface coating. This rapid clearance of SPION-based theranostic agents from circulation is one of the main challenges hampering the medical applications that differ from RES targeting. This work proposes a strategy to render biocompatible SPIONs through their encapsulation in the red blood cells (RBCs). In this work{,} the research has been focused on the multi-step optimization of chemical synthesis of magnetic nanoparticles (MNPs){,} precisely iron oxide nanoparticles (IONPs) and zinc manganese-ferrite nanoparticles (Zn/Mn FNPs){,} for encapsulation in human and murine RBCs. The encapsulation through the transient opening of RBC membrane pores requires extensive efforts to deliver high-quality nanoparticles in terms of chemical properties{,} morphology{,} stability and biocompatibility. After reaching this goal{,} in vitro experiments were performed with selected nanomaterials to investigate the potential of engineered MNP-RBC constructs in theranostic approaches.