IBI: Tobias Knopp (Head of Institute)

IBI > People > Tobias Knopp (Head of Institute)

Prof. Dr.-Ing. Tobias Knopp

Universitätsklinikum Hamburg-Eppendorf (UKE)
Sektion für Biomedizinische Bildgebung
Lottestraße 55
2ter Stock, Raum 209
22529 Hamburg
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Technische Universität Hamburg (TUHH)
Institut für Biomedizinische Bildgebung
Gebäude E, Raum 4.044
Am Schwarzenberg-Campus 3
21073 Hamburg

Tel.: 040 / 7410 56794
Fax: 040 / 7410 45811
E-Mail: t.knopp(at)uke.de
E-Mail: tobias.knopp(at)tuhh.de
ORCID: https://orcid.org/0000-0002-1589-8517

Roles

Head of the Institute for Biomedical Imaging
Editor-in-chief of the International Journal on Magnetic Particle Imaging (IJMPI)

Consulting Hours

On appointment

Research Interests

Tomographic Imaging
Image Reconstruction
Signal- and Image Processing
Magnetic Particle Imaging

Curriculum Vitae

Tobias Knopp received his Diplom degree in computer science in 2007 and his PhD in 2010, both from the University of Lübeck with highest distinction. For his PHD on the tomographic imaging method Magnetic Particle Imaging (MPI) he was awarded with the Klee award from the DGBMT (VDE) in 2011. From 2010 until 2011 he led the MAPIT project at the University of Lübeck and published the first scientific book on MPI. In 2011 he joined Bruker Biospin to work on the first commercially available MPI system. From 2012 until 2014 he worked at Thorlabs in the field of Optical Coherence Tomography (OCT) as a software developer. In 2014 he has been appointed as Professor for experimental Biomedical Imaging at the University Medical Center Hamburg-Eppendorf and the Hamburg University of Technology.

Journal Publications

[180971]

Title: Development of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapment into human erythrocytesDevelopment of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapm.

Written by: A. Antonelli, P. Szwargulski, E. S. Scarpa, F. Thieben, C. Grüttner, G. Ambrosi, L. Guidi, P. Ludewig, T. Knopp and M. Magnani

in: <em>Nanomedicine</em>. April (2020).

Volume: <strong>15</strong>. Number: (8),

on pages: 739-753

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URL: https://doi.org/10.2217/nnm-2019-0449

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Abstract: Aim: Magnetic particle imaging (MPI) is highly promising for biomedical applications, but optimal tracers for MPI, namely superparamagnetic iron oxide-based contrast agents, are still lacking. Materials & methods: The encapsulation of commercially available nanoparticles, specifically synomag®-D and perimag®, into human red blood cells (RBCs) was performed by a hypotonic dialysis and isotonic resealing procedure. The amounts of superparamagnetic iron oxide incorporated into RBCs were determined by Fe quantification using nuclear magnetic resonance and magnetic particle spectroscopy. Results: Perimag-COOH nanoparticles were identified as the best nanomaterial for encapsulation in RBCs. Perimag-COOH-loaded RBCs proved to be viable cells showing a good magnetic particle spectroscopy performance, while the magnetic signal of synomag-D-COOH-loaded RBCs dropped sharply. Conclusion: Perimag-COOH-loaded RBCs could be a potential tool for MPI diagnostic applications.

TU Hamburg

Institute for Biomedical Imaging

Lottestraße 55, 2nd floor

22529 Hamburg