Dr.-Ing. Matthias Gräser

Universitätsklinikum Hamburg-Eppendorf (UKE)
Sektion für Biomedizinische Bildgebung
Lottestraße 55
2ter Stock, Raum 212
22529 Hamburg

Technische Universität Hamburg (TUHH)
Institut für Biomedizinische Bildgebung
Gebäude E, Raum 4.044
Am Schwarzenberg-Campus 3
21073 Hamburg

Tel.: 040 / 7410 25812
E-Mail: matthias.graeser(at)tuhh.de
E-Mail: ma.graeser(at)uke.de

Research Interests

  • Magnetic Particle Imaging
  • Low Noise Electronics
  • Inductive Sensors
  • Passive Electrical Devices

Curriculum Vitae

Matthias Gräser submitted his Dr.-Ing. thesis in january 2016 at the institute of medical engineering (IMT) at the university of Lübeck and is now working as a Research Scientist at the institute for biomedical imaging (IBI) at the technical university in Hamburg, Germany.  Here he develops concepts for Magnetic-Particle-Imaging (MPI) devices. His main aim is to improve the sensitivity of the imageing devices and improve resolution and application possibilities of MPI technology.

In 2011 Matthias Gräser started to work at the IMT as a Research Associate in the Magnetic Particle Imaging Technology (MAPIT) project. In this project he devolped the analog signal chains for a rabbit sized field free line imager. Additionally he developed a two-dimensional Magnetic-Particle-Spectrometer. This device can apply various field sequences and measure the particle response with a very high signal-to-noise ratio (SNR).

The dynamic behaviour of magnetic nanoparticles is still not fully understood. Matthias Gräser investigated the particle behaviour by modeling the particle behaviour with stochastic differential equations. With this model it is possible to simulate the impact of several particle parameters and field sequences on the particle response .

In 2010 Matthias Gräser finished his diploma at the Karlsruhe Institue of Technology (KIT). His diploma thesis investigated the nerve stimulation of magnetic fields in the range from 4 kHz to 25 kHz.

Journal Publications

Journal Publications

[191077]
Title: Deep Learning Inpainting Approach for FFL-MPI sinograms.
Written by: S. Matten, M. Ahlborg, N. Blum, J. Schumacher, T. M. Buzug, M. Stille, and M. Graeser
in: <em>13th International Workshop on Magnetic Particle Imaging (IWMPI 2024)</em>. mar (2024).
Volume: <strong>10</strong>. Number: (1 Suppl 1),
on pages: 1
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URL: https://www.journal.iwmpi.org/index.php/iwmpi/article/view/674
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[www] [BibTex]

Note: inproceedings

Abstract: In Magnetic Particle Imaging (MPI), field-free line (FFL) encoding allows for setting up sinograms and use well-known algorithms from Computed Tomography (CT) for image reconstruction. Here, an FFL trajectory with a drive field (DF) direction orthogonal to rotation and translation direction of the FFL is considered. The reconstruction of each DF cycle is mapped to several sinograms along DF direction, which may result in holes within the sinograms. To fill these holes, a CT inpainting approach based on Deep Learning algorithms is adapted. Therefore, different neural network architectures were used. A U-Network, showing good results for inpainting tasks and a generative adversarial network to use a second network for evaluation of image quality. Experiments with different learning rates, architectures, encoders, data augmentation, partial convolution layers and dual domain loss have been performed and evaluated. For training, two data sets were created. From CT data intrathoracic and lower limb vessel structures were segmented to mimic MPI images. Dataset1 presents ideal information, i.e. images were transformed to radon space resulting in ideal sinograms. Dataset2 consists of synthesized MPI measurement data. Each data sets includes 12080 sinograms, split in train (60%), validation (20%) and test (20%) data. Training was started with Dataset1 and one configuration including holes. The optimum was a U-Network with a learning rate of 10-4, early stopping, ResNet50 encoder and partial convolution layers. The pre-trained network was further trained with Dataset2. This improved the performance for actual MPI measurement data. The optimized network was successfully applied for different hole configurations.

Conference Proceedings

Conference Proceedings

[191077]
Title: Deep Learning Inpainting Approach for FFL-MPI sinograms.
Written by: S. Matten, M. Ahlborg, N. Blum, J. Schumacher, T. M. Buzug, M. Stille, and M. Graeser
in: <em>13th International Workshop on Magnetic Particle Imaging (IWMPI 2024)</em>. mar (2024).
Volume: <strong>10</strong>. Number: (1 Suppl 1),
on pages: 1
Chapter:
Editor:
Publisher:
Series:
Address:
Edition:
ISBN:
how published:
Organization:
School:
Institution:
Type:
DOI:
URL: https://www.journal.iwmpi.org/index.php/iwmpi/article/view/674
ARXIVID:
PMID:

[www] [BibTex]

Note: inproceedings

Abstract: In Magnetic Particle Imaging (MPI), field-free line (FFL) encoding allows for setting up sinograms and use well-known algorithms from Computed Tomography (CT) for image reconstruction. Here, an FFL trajectory with a drive field (DF) direction orthogonal to rotation and translation direction of the FFL is considered. The reconstruction of each DF cycle is mapped to several sinograms along DF direction, which may result in holes within the sinograms. To fill these holes, a CT inpainting approach based on Deep Learning algorithms is adapted. Therefore, different neural network architectures were used. A U-Network, showing good results for inpainting tasks and a generative adversarial network to use a second network for evaluation of image quality. Experiments with different learning rates, architectures, encoders, data augmentation, partial convolution layers and dual domain loss have been performed and evaluated. For training, two data sets were created. From CT data intrathoracic and lower limb vessel structures were segmented to mimic MPI images. Dataset1 presents ideal information, i.e. images were transformed to radon space resulting in ideal sinograms. Dataset2 consists of synthesized MPI measurement data. Each data sets includes 12080 sinograms, split in train (60%), validation (20%) and test (20%) data. Training was started with Dataset1 and one configuration including holes. The optimum was a U-Network with a learning rate of 10-4, early stopping, ResNet50 encoder and partial convolution layers. The pre-trained network was further trained with Dataset2. This improved the performance for actual MPI measurement data. The optimized network was successfully applied for different hole configurations.