Florian Thieben, M.Sc.

Universitätsklinikum Hamburg-Eppendorf (UKE)
Sektion für Biomedizinische Bildgebung
Lottestraße 55
2ter Stock, Raum 202
22529 Hamburg
- Postanschrift -

Technische Universität Hamburg (TUHH)
Institut für Biomedizinische Bildgebung
Gebäude E, Raum 4.044
Am Schwarzenberg-Campus 3
21073 Hamburg

Tel.: 040 / 7410 56355
E-Mail: f.thieben(at)uke.de
E-Mail: florian.thieben(at)tuhh.de
ORCID: https://orcid.org/0000-0002-2890-5288

Research Interests

  • Magnetic Particle Imaging
  • Low noise electronics
  • Inductive sensors and filters
  • Magnetic Particle Imaging scanner characterization

Curriculum Vitae

Florian Thieben works as an electrical engineer in the group of Tobias Knopp for experimental Biomedical Imaging at the University Medical Center Hamburg-Eppendorf and the Hamburg University of Technology. In 2017 he graduated with a master's degree thesis on Entwicklung eines kompakten Magnet Partikel Spektrometers mit gradiometrischer Empfangskette".

Journal Publications

[164760]
Title: MPI tracer interactions and their effect on signal stability.
Written by: L. Moor, S. Scheibler, L. Gerken, K. Scheffler, F. Thieben, T. Knopp, I. Herrmann, and F. Starsich
in: <em>International Journal on Magnetic Particle Imaging</em>. (2022).
Volume: <strong>8</strong>. Number: (1),
on pages: 1-3
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DOI: 10.18416/IJMPI.2022.2203056
URL: https://doi.org/10.18416/IJMPI.2022.2203056
ARXIVID:
PMID:

[www]

Note: inproceedings

Abstract: Nanoparticles tend to agglomerate following their in vivo or in vitro application. This leads to particle interaction and, for magnetic particle imaging (MPI) tracers, to magnetic coupling phenomena. Here, we investigate these effects and their influence on magnetic particle spectroscopy (MPS) and MPI signal stability. Highly magnetic flame-made Zn-ferrites with controlled interparticle distance are suggested as a stable MPI tracer system. Due to their pre-aggregated morphology, additional agglomeration does not substantially alter their magnetic response. This is in strong contrast to frequently investigated polymer-coated iron oxide nanoparticles, which show a massive MPS signal loss in a biologically relevant dispersion medium compared to water. This effect is also shown during MPI and renders these tracers inapplicable to further applications. Our flame-made Zn-ferrites, on the other hand, show sufficient signal stability, which allows their detailed quantification via MPI.

Conference Proceedings

[164760]
Title: MPI tracer interactions and their effect on signal stability.
Written by: L. Moor, S. Scheibler, L. Gerken, K. Scheffler, F. Thieben, T. Knopp, I. Herrmann, and F. Starsich
in: <em>International Journal on Magnetic Particle Imaging</em>. (2022).
Volume: <strong>8</strong>. Number: (1),
on pages: 1-3
Chapter:
Editor:
Publisher:
Series:
Address:
Edition:
ISBN:
how published:
Organization:
School:
Institution:
Type:
DOI: 10.18416/IJMPI.2022.2203056
URL: https://doi.org/10.18416/IJMPI.2022.2203056
ARXIVID:
PMID:

[www] [BibTex]

Note: inproceedings

Abstract: Nanoparticles tend to agglomerate following their in vivo or in vitro application. This leads to particle interaction and, for magnetic particle imaging (MPI) tracers, to magnetic coupling phenomena. Here, we investigate these effects and their influence on magnetic particle spectroscopy (MPS) and MPI signal stability. Highly magnetic flame-made Zn-ferrites with controlled interparticle distance are suggested as a stable MPI tracer system. Due to their pre-aggregated morphology, additional agglomeration does not substantially alter their magnetic response. This is in strong contrast to frequently investigated polymer-coated iron oxide nanoparticles, which show a massive MPS signal loss in a biologically relevant dispersion medium compared to water. This effect is also shown during MPI and renders these tracers inapplicable to further applications. Our flame-made Zn-ferrites, on the other hand, show sufficient signal stability, which allows their detailed quantification via MPI.