Master's thesis, CFD simulation, model validation

Master's thesis, CHO cell cultivation, antibody product quality

Bioconversion of glycerol to 3-Hydroxypropionaldehyd

Entwicklung von Verfahren zur Produktion und Aufarbeitung von 3-Hydroxypropionaldehyd

	Contact:	Prof. Dr. An-Ping Zeng
	email:	aze@tu-harburg.de
	phone:	+49 40 42878 4183
	fax:	+49 40 42878 2909

Cell culture technology

	Contact:	Prof. Dr.-Ing. Ralf Pörtner
	email:	poertner@tu-harburg.de
	phone:	+49 40 42878 2886
	fax:	+49 40 42878 2909

Im Bereich "Zellkulturtechnik" bieten wir in den folgenden Schwerpunkten Themen für Diplomarbeiten an:

Entwicklung von Festbettreaktoren fur die Kultur tierischer Zellen auf makroporösen Trägermaterialien; Einsatzgebiete: Produktion monoklonaler Antikörper, rekombinante adhärente Zellen, physiologische Untersuchungen an Tumorzellen, künstliche Organe (Leber)

Entwicklung von Fütterungsstrategien und modellgestützte Prozessführung für Zellkulturen

Kultivierung von Chondrozyten zur Erstellung eines implantierbaren Gelenkknorpelersatzes "in vitro"

Continuous cultivation of lactic acid bacteria

There have been numerous studies on the conversion of sugars, including glucose, lactose and sucrose, to lactic acid and valuable secondary metabolites with lactic acid bacteria in different types of processes to achieve higher productivity. The fermentation by conventional methods that use cell suspension in batch processes has several limitations, such as low productivity, product inhibition and also the variation from batch to batch. Cell immobilization techniques have become more important and popular because it gives many advantages compared to cell suspension culture such as maintenance of stable and active biocatalysts, accelerated reaction rates, high volumetric productivity, improved process control, reduced susceptibility of cells to contamination, improved production efficiency and no possibility of washout.

The aim of this project is to optimize the performance of long-term cultures of lactic acid bacteria in a fixed-bed reactor system.