Systems Biology

Functional genomics is used in combination with engineering tools and mathematical modeling to study cellular processes at multiple molecular levels (interacting networks). In particular, we deal with fast dynamics of metabolism, its compartmentation and the role of metabolites in gene regulation. Efforts are made to develop synthetic pathways and minimal cells in a long term.

Project examples:

• DFG: Development and Mathematical Modeling of a Bioconversion Process Involving Microbial Community


• SysLogics(BMBF) - Systems Biology of Cell Culture for Biologics


• General introduction
• Cell Ensemble Modeling and Analysis of Synchronized Cell Cultures
• Integrierte „Omics“ Datenanalyse für Systembiologie
• Synchronization of eukaryotic cells for Systems Biology Research
• Workpackage: Dynamic modeling of pyruvate dehydrogenase complex in mammalian cells
• BioInSys(BMBF) - Development of Biofilm Inhibitors Using a Systems Biology Approach


• General introduction
• Workpackage: Sequencing, comparative genomics and data integration
• Workpackage: Reverse engineering for reconstruction of regulatory network from functional genomic data
• Workpackage: Integrated and dynamic modeling of networks
• Workpackage: Proteomic and metabolic analyses
• BMBF/TUHH: Microtechnology and System Integration for Metabolomic Analysis of Mammalian Cells


• TUHH:
  Development of New Methods for Fast Sampling and Sample Processing for Microbial Metabolomics


• TUHH/DFG:
  Technology Development for Applied Research on the Metabolism of Host-adapted Bacterial Pathogens


• SysCompart(BMBF): New technologies and methods for analysing and modelling dynamics of eukaryotic metabolism involved in compartmentation


• General introduction
• Workpackage: New technologies and methods for analyzing and modeling dynamics of eukaryotic metabolism involved in compartmentation
• Workpackage: Spatiotemporal modelling of selected enzymes and metabolic pathways
• SynBio - Fundamentals for synthetic biological systems


• General introduction
• Workpackage: Modeling and design of synthetic metabolic pathways
• Workpackage: Multistep bioreaction engineering of an enzymatic production process for 1,3-propanediol from glycerol
• Biochemical reaction database and bioinformatics tools