Institute of Thermal Separation Processes

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Publications



Patents

  • Johannsen, M.,
    Process for the preparation of vitamin D3 and provitamin D3, 2000, European Patent No. EP 969001A2


Posters and presentations

  • M. Sun, M. Johannsen, P. Gurikov, I. Smirnova
    Design of Stationary Phases for Enantiomeric Separations in Supercritical Fluid Chromatography (Lecture)
    ahrestreffen der ProcessNet-Fachgruppen Mechanische Flüssigkeitsabtrennung, Kristallisation, Phytoextrakte, Adsorption, Extraktion, Fluidverfahrenstechnik und Membrantechnik, Cologne, Germany, 2017

  • M. Sun, M.Johannsen, I. Smirnova
    Selective Adsorption with Immobilized (S)-Ibuprofen as Chiral Selector (poster)
    12th International Conference on the Fundamentals of Adsorption, Friedrichshafen, Germany, 2016

  • M. Sun, P. Gurikov, I. Smirnova, M. Johannsen
    Chiral Stationary Phases Designed for Enantiomeric Separation of 2-Arylpropionic Acid Derivatives in SFC (poster)
    10th International Conference on Packed Column SFC, Vienna, Austria, 2016

  • M. Sun, P. Gurikov, I. Smirnova, M. Johannsen
    Synthesis of stationary phases for chiral separations of 2-arylpropionic acid derivatives (Poster)
    SPICA 2016 - 16th International Symposium on Preparative and Industrial Chromatography and Allied Techniques, Vienna, Austria, 2016

  • J. Kern, M. Johannsen
    Adsorption equilibria in High Pressure Drop Columns: Experimental approach and thermodynamic modeling (Poster).
    10th International Conference on Packed-Column SFC, Vienna, Austria, 2016

  • M. Sun, P. Gurikov, I. Smirnova, M. Johannsen
    Sol-gel Encapsulation of Ibuprofen for Enantiomeric Separation (poster)
    International Seminar on Aerogels, Sophia Antipolis, France, 2016

  • Kern, J., Johannsen, M.
    Nanoscale Hollow Spheres for Adsorptive Enantiomeric Separation using supercritical CO2 (poster)
    PREP 2013 – 26th International Symposium on Preparative and Process Chromatography, Ion Exchange, Adsorption Processes & Related Techniques, Boston, U.S.A., 2013

  • Kern, J., Johannsen, M
    Nanoscale Hollow Spheres for Adsorptive Enantiomeric Separation using supercritical CO2 (Lecture)
    7th International Conference on Packed-Column SFC, Boston, U.S.A., 2013

  • Bolten, D., Kern, J., Simonato, S., Feldmann, C., Johannsen, M., Türk, M.
    Untersuchungen zum Einsatz nanoskaliger Hohlkugeln als Adsorbens zur Enantiomerentrennung mit überkritischen Fluiden (Lecture)
    Jahrestreffen der Fachgruppe Hochdruckverfahrenstechnik der DECHEMA, Berlin-Adlershof, Deutschland, 2013

  • Bolten, D., Türk, M., Staudt, R., Kern, J., Johannsen, M.
    Nanoskalige Hohlkugeln: Adsorption von Gasen und/oder organischen Wirkstoffen (Lecture)
    6. Symposium Produktgestaltung in der Partikeltechnologie, Clausthal-Zellerfeld, Deutschland, 2013

  • Cumana, S., Johannsen, M., Smirnova, I.
    Application of Silica Aerogels as Stationary Phase in Supercritical Fluid Chromatography
    12th International Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA), Stockholm, Sweden, 2010

  • Chuang, M.-H., Johannsen, M.
    Characterization of pH in aqueous CO2-systems (Poster)
    International Symposium on Supercritical Fluids, Arcachon, France, 2009

  • Chuang, M.-H., Johannsen, M.
    Multi-component adsorption equilibria from sub- and supercritical fluid phases (Key Note Lecture)
    International Symposium on Supercritical Fluids, Arcachon, France, 2009

  • Johannsen, M.
    Preparative Supercritical Fluid Chromatography as Successful Separation Tool in Chemical and Pharmaceutical Industry (Invited Lecture)
    Conference on preparative & Process Scale HPLC, MCC and SFC, Särö, Sweden, 2009

  • Johannsen, M.
    Preparative Chromatography with Supercritical Fluids - Operation and Optimisation (Invited Lecture)
    2nd International Conference on Packed-Column SFC, Zurich, Switzerland, 2008

  • Chuang, M.-H., Johannsen, M.
    Sub-/Supercritical fluid chromatography with propane (Poster)
    11th International Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA), Zurich, Switzerland, 2008

  • Peper, S., Johannsen, M., Brunner, G.
    Preparative Chromatography with Supercritical Fluids - Comparison of SMB and Batch Process (Lecture)
    PREP 2007 – 20th International Symposium on Preparative/Process Chromatography, Ion Exchange, Adsorption / Desorption Processes & Related Techniques, Baltimore, USA, 2007

  • Chuang, M.-H., Johannsen, M.
    Adsorption From Supercritical Solution (Poster)
    9th International Conference on Fundamentals of Adsorption (FOA), Giardini Naxos, Sicily - Italy, 2007

  • Chuang, M.-H., Johannsen, M.
    Adsorption from supercritical solution (Poster)
    6th Euro Fed Lipid Congress, Athens, Greece, 2007

  • Chuang, M.-H., Johannsen, M., Brunner, G.
    Concentration of minor components in crude palm oil (Lecture)
    5th Euro Fed Lipid Congress, Gothenburg, Sweden, 2007

  • Kaemmerer, H., Peper, S., Johannsen, M., Brunner, G.
    Realisation of solvent cycles in preparative SFC plants (Poster)
    11th International Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA), Innsbruck, Austria, 2006

  • Bolten, D., Johannsen, M.
    Influence of modifier concentration on the adsorption behaviour of α- and δ-tocopherol on silica gel (Poster)
    3rd International Meeting on High Pressure Chemical Engineering, Erlangen, Germany, 2006

  • S. Peper, Johannsen, M., Brunner, G.
    Preparative chromatography with supercritical fluids – comparison of SMB and batch process (Lecture)
    3rd International Meeting on High Pressure Chemical Engineering, Erlangen, Germany, 2006

  • Johannsen, M., Brunner, G., S. Peper
    Preparative chromatography with supercritical fluids – comparison of SMB and batch process (Poster)
    11th International Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA), Innsbruck, Austria, 2006

  • Johannsen, M., Giese, T., Luebbert, M., Peper, S., Brunner, G.
    Adsorption aus überkritischen Lösungen (Plenarvortrag)
    Interne Arbeitssitzung des GVC-Fachausschusses „Fluidverfahrenstechnik“, DECHEMA/GVC-Arbeitsausschusses „Adsorption", GVC-Fachausschusses „Hochdruckverfahrenstechnik“,, Lübeck, Germany, 2005

  • Rajendran, A., Peper, S., Mazzotti, H., Johannsen, M., Morbidelli, M.
    Supercritical Fluid Simulated Moving Bed (SF-SMB) enantioseparation of 1-phenyl-1-propanol (Poster)
    10th International Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA), Aachen, Germany, 2004

  • Peper, S., Johannsen, M., Brunner, G.
    Preparative separation of tocochromanols with supercritical fluid chromatography (Lecture)
    10th International Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA), Aachen, Germany, 2004

  • Peper, S., Johannsen, M., Brunner, G.
    Supercritical Fluid Chromatography as Successful Separation Tool in Chemical and Pharmaceutical Industry (Lecture)
    7th Italian Conference on Supercritical Fluids and Their Applications and the 9th Meeting on Supercritical Fluids, Trieste, Italy, 2004

  • Ibe, R., Johannsen, M., Zetzl, C., Brunner, G
    Screening von SFE-Extrakten des brasilianischen Regenwalds, Workshop "Phytoextrakte" (Poster)
    DECHEMA, Frankfurt, Germany, 2004

  • Johannsen, M., Brunner, G.
    Supercritical Fluid Chromatography as Successful Separation Tool in Chemical and Pharmaceutical Industry (Poster)
    6th International Symposium on Supercritical Fluids, Versailles, France, 2003

  • Peper, S., Johannsen, M., Brunner, G.
    Adsorption equilibria from supercritical solutions (Poster)
    6th International Symposium on Supercritical Fluids, Versailles, France, 2003

  • Peper, S., Johannsen, M., Brunner, G.
    Supercritical fluid simulated moving bed chromatography - Process optimisation of the separation of tocopherol homologues (Poster)
    6th International Symposium on Supercritical Fluids, Versailles, France, 2003

  • Johannsen, M., Peper, S., Lübbert, M.
    Simulated moving bed chromatography with supercritical fluids for successful separations of enantiomers and other isomers (Lecture)
    ISC´02 – 24th International Symposium on Chromatography, Leipzig, Germany, 2002

  • Lübbert, M., Johannsen, M., Brunner, G.
    Supercritical Fluid Simulated Moving Bed Chromatography: Simulation - Operation - Optimisation (Lecture)
    9th International Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA), Heidelberg, Germany, 2002

  • Johannsen, M., Peper, S., Lübbert, M.
    The sucessful use of simulated moving bed chromatography with supercritical fluids (SFC-SMB) for preparative scale chiral separations (Invited Lecture)
    PREPTECH 2002 - Preparative and process scale technology in the manufacturing of chemicals and pharmaceuticals, Gothenburg, Sweden, 2002

  • Johannsen, M., Peper, S., Lübbert, M.
    The successful use of simulated moving bed chromatography with supercritical fluids for the separation of enantiomers (Lecture)
    ISCD-14 – 14th International Symposium on Chirality, Hamburg, Germany, 2002

  • Johannsen, M., Peper, S., Buss, V., Lübbert, M.
    Preparative SFC: A versatile tool for the purification of high-value products (Invited Lecture)
    10th International Symposium on Supercritical Fluid Chromatography, and Extraction, and Processing, Myrtle Beach, U.S.A., 2001

  • Zetzl, C., Johannsen, M., Peper, S., Brunner, G., Benkedda, J., Barth, D., Viriot, M. L., Nicoud, R. M.
    Couplage de chromatographie supercritique et isomérisation photonique: développement d´un nouveau réacteur integré du type lit mobile simulé (Poster)
    8me Congrés Francophone de Génie des Procédés, Nancy, France, 2001

  • Buss, V., Johannsen, G. Brunner
    Preparative supercritical fluid chromatography in elution mode (Poster)
    2nd International Meeting on High Pressure Chemical Engineering, Hamburg, Germany, 2001

  • Johannsen, M., Lübbert, M., Brunner, G.
    Determination of Adsorption Isotherms from Supercritical Fluids (Plenary Lecture)
    Meeting of the Technical Committees "Adsorption" (DECHEMA) and "Thermal Separation of Gas- and Fluid-Mixtures" (GVC) together with the Working Party on "Distillation, Absorption and Extraction", Bamberg, Germany, 2001

  • Johannsen, M., Peper, S., Lübbert, M., Giese, T., Brunner, G.
    Separation of ibuprofen isomeres by supercritical fluid simulated moving bed chromatography (Poster)
    PREPTECH 2001 - Preparative and process scale technology in the manufacturing of chemicals and pharmaceuticals, Mainz, Germany, 2001

  • Johannsen, M., Lübbert, M., Brunner, G.
    Adsorption from supercritical mixtures of carbon dioxide and modifiers (Poster)
    2nd International Meeting on High Pressure Chemical Engineering, Hamburg, Germany, 2001

  • Johannsen, M., Peper, S., Lübbert, M., Brunner, G.
    Separation of binary mixtures by supercritical fluid simulated moving bed chromatography (Poster)
    2nd International Meeting on High Pressure Chemical Engineering, Hamburg, Germany, 2001

  • Johannsen, M., Peper, S., Depta, A., Giese, T., Brunner, G.
    SMB-SFC for isomer separation (Invited Lecture)
    4th European Symposium on Analytical Supercritical Fluid Chromatography and Extraction and the 9th International Symposium on Supercritical Fluid Chromatography and Extraction, Munich, Germany, 2000

  • Johannsen, M., Peper, S., Depta, A., Giese, T., Brunner, G.
    SMB-SFC for isomer separation (Lecture)
    8th International Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA), Zurich, Switzerland, 2000

  • Zetzl, C., Peper, S., Johannsen, M., Brunner, G., Benkedda, J., Barth, D., Viriot, M. L., Nicoud, R. M.
    Coupling of photoisomerization and supercritical fluid chromatography for developing a new integrated simulated moving bed reactor (Lecture)
    7th Meeting on Supercritical Fluids: Particle Design – Materials and Natural Products Processing, Antibes/Juan-les-Pins, France, 2000

  • Peper, S., Lübbert, M., Johannsen, M. Giese, T., Depta, A., Brunner, G.
    Supercritical fluid simulated moving bed chromatography: modeling, operation and simulation
    7th Meeting on Supercritical Fluids: Particle Design – Materials and Natural Products Processing, Antibes/Juan-les-Pins, France, 2000

  • Johannsen, M., Depta, A., Giese, T., Brunner, G.
    Separation of Phytol Stereoisomers in a SFC-SMB Plant (Lecture)
    PREP ´99 – 12th International Symposium on Preparative/Process Chromatography & Related Techniques, , San Francisco, USA, 1999

  • Johannsen, M., Depta, A., Giese, T., Brunner, G.
    Separation of stereoisomers in a SMB-SFC plant - determination of isotherms and simulation
    Proc. International Meeting of the GVC-Fachausschuss Hochdruckverfahrenstechnik, Karlsruhe, Germany, 1999

  • Johannsen, M., Depta, A., Giese, T., Brunner, G.
    Separation of Stereoisomers in a SMB-SFC Plant (Lecture)
    CISP´99 – 5th Italian Conference on Supercritical Fluids and Their Applications, Garda, Italy, 1999

  • Johannsen, M., Brunner, G.
    Mathematical simulation of supercritical fluid chromatography (Poster)
    PREP ´96 – 6th International Symposium on Preparative and Industrial Chromatography and Related Techniques, Basle, Switzerland, 1996

  • Johannsen, M., Brunner, G.
    Determination of thermodynamic data with on-line PSFC: Measurement and correlation of solubilities (Invited Lecture)
    7th International Symposium on Supercritical Fluid Chromatography and Extraction, Indianapolis, USA, 1996

  • Johannsen, M., Brunner, G.
    Investigations by SFC for characterization of SFE (Lecture)
    3rd European Symposium on Analytical Supercritical Fluid Chromatography and Extraction and the 6th International Symposium on Supercritical Fluid Chromatography and Extraction, Uppsala, Sweden, 1995

  • Johannsen, M., Brunner, G
    A supercritical fluid chromatographic system for investigations of solubilities and retention behaviour (Poster)
    Proceedings of the 5th International Symposium on Supercritical Fluid Chromatography and Extraction, Baltimore, USA, 1994

  • Johannsen, M., Brunner, G
    Apparatus for quick and accurate determination of solubilities in supercritical fluids. Solubilities of xanthines in supercritical carbon dioxide/methanol mixtures (Lecture)
    Proceedings of the 3rd International Symposium on Supercritical Fluid, Strasbourg, France, 1994

  • Johannsen, M., Brunner, G.
    A supercritical fluid chromatographic system for investigations of solubilities and retention behaviour (Poster)
    Book of Abstracts of the 17th International Symposium on Column Liquid Chromatography, Hamburg, Germany, 1993

Theses

Johannsen, M.  2004
Chromatographie mit überkritischen Gasen
Habilitation Technische Universität Hamburg-Harburg, Mensch & Buch Verlag: Berlin

Johannsen, M., 1995
Experimentelle Untersuchungen und Korrelierung des Löseverhaltens von Naturstoffen in überkritischem Kohlendioxid
Dissertation Technische Universität Hamburg-Harburg

Johannsen, M., 1990
Die Bestimmung nat. Vitamin K1-Gehalte in Ölen und ölreichen Samen mittels HPLC
Diplomarbeit Universität Hamburg

Reports

Chuang, M.-H., Johannsen, M., 2008
Multikomponenten-Adsorptionsgleichgewichte aus unter- und überkritischen Lösungen
Arbeitsbericht zum DFG-Forschungsvorhaben Jo 339/6-1

Bezold, A., Johannsen, M., Brunner, G., 2005
Adsorptionsgleichgewichte in Zwei- oder Mehrkomponentensystemen unter erhöhten Drücken
Abschlussbericht zum DFG-Forschungsvorhaben Br 846/20-1/2

Lübbert, M., Johannsen, M., Brunner, G., 2003
Multikomponenten-Adsorptionsgleichgewichte aus unter- und überkritischen Lösungen
Abschlussbericht zum DFG-Forschungsvorhaben Jo 339/1-2

Johannsen, M., 2003
Reindarstellung chiraler Substanzen mittels präparativer Chromatographie mit überkritischem Kohlendioxid
Arbeitsbericht zum DFG-Forschungsvorhaben Jo 339/2-2

Johannsen, M., 2001
Reindarstellung chiraler Substanzen mittels präparativer Chromatographie mit überkritischem Kohlendioxid
Arbeitsbericht zum DFG-Forschungsvorhaben Jo 339/2-1

Lübbert, M., Johannsen, M., Brunner, G., 2000
Adsorptionsgleichgewichte in Zwei- oder Mehrkomponentensystemen unter erhöhten Drücken
Arbeitsbericht zum DFG-Forschungsvorhaben Jo 339/1-1

Johannsen, M., Brunner, G., 1996
Fluidchromatographische Untersuchungen zur Charakterisierung der Gasextraktion (SFE) aus Feststoffen
Abschlussbericht zum DFG-Forschungsvorhaben Br 846/9-2

Johannsen, M., Brunner, G., 1993
Fluidchromatographische Untersuchungen zur Charakterisierung der Gasextraktion (SFE) aus Feststoffen
Arbeitsbericht zum DFG-Forschungsvorhaben Br 846/9-1