Institute of Thermal Separation Processes

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Publications



Patents

  • Johannsen, M.,
    Process for the preparation of vitamin D3 and provitamin D3, 2000, European Patent No. EP 969001A2


Posters and presentations

  • D. Niehaus, M. Johannsen, D. Ohde, F. Perz, P. Bubenheim, G. Liebsch, A. Liese, M. Schlüter
    Design of aerated high pressure reactors for enzyme catalysed reactions (Poster)
    Himmelfahrtstagung on Bioprocess Engineering 2021, DECHEMA (online)/Germany, 2021

  • C. Spille, V. Tholan, M. Johannsen, M. Hoffmann, M. Schlüter
    Electrical Capacitance Volume Tomography (ECVT) of Additively Manufactured Lattice Structures (AMLS) in Gas-Liquid Systems (Lecture)
    ahrestreffen der ProcessNet Fachgruppe Mehrphasenströmung, ProcessNet (online)/Germany, 2021

  • D. Niehaus, M. Johannsen, M. Schlüter
    Design of aerated high pressure reactors for enzymatic catalyzed reactions (Poster)
    1. Hamburg-Bochumer Mehrphasensymposium, Online/Hamburg, 2020

  • M. Sun, M. Johannsen, P. Gurikov, I. Smirnova
    Design of Stationary Phases for Enantiomeric Separations in Supercritical Fluid Chromatography (Lecture)
    Jahrestreffen der ProcessNet-Fachgruppen Mechanische Flüssigkeitsabtrennung, Kristallisation, Phytoextrakte, Adsorption, Extraktion, Fluidverfahrenstechnik und Membrantechnik, Cologne, Germany, 2017

  • M. Sun, P. Gurikov, I. Smirnova, M. Johannsen
    Synthesis of Stationary Phases for Chiral Separations by SFC (Invited Lecture)
    Conference on Preparative & Process Scale HPLC, MCC and SFC, Särö, Sweden, 2017

  • J. Kern, M. Johannsen
    Adsorption equilibria in High Pressure Drop Columns: Experimental approach and thermodynamic modeling (Poster).
    10th International Conference on Packed-Column SFC, Vienna, Austria, 2016

  • M. Sun, P. Gurikov, I. Smirnova, M. Johannsen
    Synthesis of stationary phases for chiral separations of 2-arylpropionic acid derivatives (Poster)
    SPICA 2016 - 16th International Symposium on Preparative and Industrial Chromatography and Allied Techniques, Vienna, Austria, 2016

  • M. Sun, M.Johannsen, I. Smirnova
    Selective Adsorption with Immobilized (S)-Ibuprofen as Chiral Selector (poster)
    12th International Conference on the Fundamentals of Adsorption, Friedrichshafen, Germany, 2016

  • M. Sun, P. Gurikov, I. Smirnova, M. Johannsen
    Chiral Stationary Phases Designed for Enantiomeric Separation of 2-Arylpropionic Acid Derivatives in SFC (poster)
    10th International Conference on Packed Column SFC, Vienna, Austria, 2016

  • M. Sun, P. Gurikov, I. Smirnova, M. Johannsen
    Sol-gel Encapsulation of Ibuprofen for Enantiomeric Separation (poster)
    International Seminar on Aerogels, Sophia Antipolis, France, 2016

  • Kern, J., Johannsen, M.
    Nanoscale Hollow Spheres for Adsorptive Enantiomeric Separation using supercritical CO2 (poster)
    PREP 2013 – 26th International Symposium on Preparative and Process Chromatography, Ion Exchange, Adsorption Processes & Related Techniques, Boston, U.S.A., 2013

  • Bolten, D., Türk, M., Staudt, R., Kern, J., Johannsen, M.
    Nanoskalige Hohlkugeln: Adsorption von Gasen und/oder organischen Wirkstoffen (Lecture)
    6. Symposium Produktgestaltung in der Partikeltechnologie, Clausthal-Zellerfeld, Deutschland, 2013

  • Kern, J., Johannsen, M
    Nanoscale Hollow Spheres for Adsorptive Enantiomeric Separation using supercritical CO2 (Lecture)
    7th International Conference on Packed-Column SFC, Boston, U.S.A., 2013

  • Bolten, D., Kern, J., Simonato, S., Feldmann, C., Johannsen, M., Türk, M.
    Untersuchungen zum Einsatz nanoskaliger Hohlkugeln als Adsorbens zur Enantiomerentrennung mit überkritischen Fluiden (Lecture)
    Jahrestreffen der Fachgruppe Hochdruckverfahrenstechnik der DECHEMA, Berlin-Adlershof, Deutschland, 2013

  • Cumana, S., Johannsen, M., Smirnova, I.
    Application of Silica Aerogels as Stationary Phase in Supercritical Fluid Chromatography
    12th International Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA), Stockholm, Sweden, 2010

  • Chuang, M.-H., Johannsen, M.
    Multi-component adsorption equilibria from sub- and supercritical fluid phases (Key Note Lecture)
    International Symposium on Supercritical Fluids, Arcachon, France, 2009

  • Chuang, M.-H., Johannsen, M.
    Characterization of pH in aqueous CO2-systems (Poster)
    International Symposium on Supercritical Fluids, Arcachon, France, 2009

  • Johannsen, M.
    Preparative Supercritical Fluid Chromatography as Successful Separation Tool in Chemical and Pharmaceutical Industry (Invited Lecture)
    Conference on preparative & Process Scale HPLC, MCC and SFC, Särö, Sweden, 2009

  • Chuang, M.-H., Johannsen, M.
    Sub-/Supercritical fluid chromatography with propane (Poster)
    11th International Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA), Zurich, Switzerland, 2008

  • Johannsen, M.
    Preparative Chromatography with Supercritical Fluids - Operation and Optimisation (Invited Lecture)
    2nd International Conference on Packed-Column SFC, Zurich, Switzerland, 2008

  • Chuang, M.-H., Johannsen, M.
    Adsorption From Supercritical Solution (Poster)
    9th International Conference on Fundamentals of Adsorption (FOA), Giardini Naxos, Sicily - Italy, 2007

  • Chuang, M.-H., Johannsen, M.
    Adsorption from supercritical solution (Poster)
    6th Euro Fed Lipid Congress, Athens, Greece, 2007

  • Peper, S., Johannsen, M., Brunner, G.
    Preparative Chromatography with Supercritical Fluids - Comparison of SMB and Batch Process (Lecture)
    PREP 2007 – 20th International Symposium on Preparative/Process Chromatography, Ion Exchange, Adsorption / Desorption Processes & Related Techniques, Baltimore, USA, 2007

  • Chuang, M.-H., Johannsen, M., Brunner, G.
    Concentration of minor components in crude palm oil (Lecture)
    5th Euro Fed Lipid Congress, Gothenburg, Sweden, 2007

  • Johannsen, M., Brunner, G., S. Peper
    Preparative chromatography with supercritical fluids – comparison of SMB and batch process (Poster)
    11th International Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA), Innsbruck, Austria, 2006

  • S. Peper, Johannsen, M., Brunner, G.
    Preparative chromatography with supercritical fluids – comparison of SMB and batch process (Lecture)
    3rd International Meeting on High Pressure Chemical Engineering, Erlangen, Germany, 2006

  • Bolten, D., Johannsen, M.
    Influence of modifier concentration on the adsorption behaviour of α- and δ-tocopherol on silica gel (Poster)
    3rd International Meeting on High Pressure Chemical Engineering, Erlangen, Germany, 2006

  • Kaemmerer, H., Peper, S., Johannsen, M., Brunner, G.
    Realisation of solvent cycles in preparative SFC plants (Poster)
    11th International Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA), Innsbruck, Austria, 2006

  • Johannsen, M., Giese, T., Luebbert, M., Peper, S., Brunner, G.
    Adsorption aus überkritischen Lösungen (Plenarvortrag)
    Interne Arbeitssitzung des GVC-Fachausschusses „Fluidverfahrenstechnik“, DECHEMA/GVC-Arbeitsausschusses „Adsorption", GVC-Fachausschusses „Hochdruckverfahrenstechnik“,, Lübeck, Germany, 2005

  • Peper, S., Johannsen, M., Brunner, G.
    Supercritical Fluid Chromatography as Successful Separation Tool in Chemical and Pharmaceutical Industry (Lecture)
    7th Italian Conference on Supercritical Fluids and Their Applications and the 9th Meeting on Supercritical Fluids, Trieste, Italy, 2004

  • Rajendran, A., Peper, S., Mazzotti, H., Johannsen, M., Morbidelli, M.
    Supercritical Fluid Simulated Moving Bed (SF-SMB) enantioseparation of 1-phenyl-1-propanol (Poster)
    10th International Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA), Aachen, Germany, 2004

  • Ibe, R., Johannsen, M., Zetzl, C., Brunner, G
    Screening von SFE-Extrakten des brasilianischen Regenwalds, Workshop "Phytoextrakte" (Poster)
    DECHEMA, Frankfurt, Germany, 2004

  • Peper, S., Johannsen, M., Brunner, G.
    Preparative separation of tocochromanols with supercritical fluid chromatography (Lecture)
    10th International Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA), Aachen, Germany, 2004

  • Peper, S., Johannsen, M., Brunner, G.
    Adsorption equilibria from supercritical solutions (Poster)
    6th International Symposium on Supercritical Fluids, Versailles, France, 2003

  • Peper, S., Johannsen, M., Brunner, G.
    Supercritical fluid simulated moving bed chromatography - Process optimisation of the separation of tocopherol homologues (Poster)
    6th International Symposium on Supercritical Fluids, Versailles, France, 2003

  • Johannsen, M., Brunner, G.
    Supercritical Fluid Chromatography as Successful Separation Tool in Chemical and Pharmaceutical Industry (Poster)
    6th International Symposium on Supercritical Fluids, Versailles, France, 2003

  • Johannsen, M., Peper, S., Lübbert, M.
    The sucessful use of simulated moving bed chromatography with supercritical fluids (SFC-SMB) for preparative scale chiral separations (Invited Lecture)
    PREPTECH 2002 - Preparative and process scale technology in the manufacturing of chemicals and pharmaceuticals, Gothenburg, Sweden, 2002

  • Johannsen, M., Peper, S., Lübbert, M.
    Simulated moving bed chromatography with supercritical fluids for successful separations of enantiomers and other isomers (Lecture)
    ISC´02 – 24th International Symposium on Chromatography, Leipzig, Germany, 2002

  • Lübbert, M., Johannsen, M., Brunner, G.
    Supercritical Fluid Simulated Moving Bed Chromatography: Simulation - Operation - Optimisation (Lecture)
    9th International Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA), Heidelberg, Germany, 2002

  • Johannsen, M., Peper, S., Lübbert, M.
    The successful use of simulated moving bed chromatography with supercritical fluids for the separation of enantiomers (Lecture)
    ISCD-14 – 14th International Symposium on Chirality, Hamburg, Germany, 2002

  • Johannsen, M., Peper, S., Lübbert, M., Giese, T., Brunner, G.
    Separation of ibuprofen isomeres by supercritical fluid simulated moving bed chromatography (Poster)
    PREPTECH 2001 - Preparative and process scale technology in the manufacturing of chemicals and pharmaceuticals, Mainz, Germany, 2001

  • Johannsen, M., Lübbert, M., Brunner, G.
    Determination of Adsorption Isotherms from Supercritical Fluids (Plenary Lecture)
    Meeting of the Technical Committees "Adsorption" (DECHEMA) and "Thermal Separation of Gas- and Fluid-Mixtures" (GVC) together with the Working Party on "Distillation, Absorption and Extraction", Bamberg, Germany, 2001

  • Zetzl, C., Johannsen, M., Peper, S., Brunner, G., Benkedda, J., Barth, D., Viriot, M. L., Nicoud, R. M.
    Couplage de chromatographie supercritique et isomérisation photonique: développement d´un nouveau réacteur integré du type lit mobile simulé (Poster)
    8me Congrés Francophone de Génie des Procédés, Nancy, France, 2001

  • Johannsen, M., Peper, S., Buss, V., Lübbert, M.
    Preparative SFC: A versatile tool for the purification of high-value products (Invited Lecture)
    10th International Symposium on Supercritical Fluid Chromatography, and Extraction, and Processing, Myrtle Beach, U.S.A., 2001

  • Johannsen, M., Peper, S., Lübbert, M., Brunner, G.
    Separation of binary mixtures by supercritical fluid simulated moving bed chromatography (Poster)
    2nd International Meeting on High Pressure Chemical Engineering, Hamburg, Germany, 2001

  • Buss, V., Johannsen, G. Brunner
    Preparative supercritical fluid chromatography in elution mode (Poster)
    2nd International Meeting on High Pressure Chemical Engineering, Hamburg, Germany, 2001

  • Johannsen, M., Lübbert, M., Brunner, G.
    Adsorption from supercritical mixtures of carbon dioxide and modifiers (Poster)
    2nd International Meeting on High Pressure Chemical Engineering, Hamburg, Germany, 2001

  • Johannsen, M., Peper, S., Depta, A., Giese, T., Brunner, G.
    SMB-SFC for isomer separation (Invited Lecture)
    4th European Symposium on Analytical Supercritical Fluid Chromatography and Extraction and the 9th International Symposium on Supercritical Fluid Chromatography and Extraction, Munich, Germany, 2000

  • Peper, S., Lübbert, M., Johannsen, M. Giese, T., Depta, A., Brunner, G.
    Supercritical fluid simulated moving bed chromatography: modeling, operation and simulation
    7th Meeting on Supercritical Fluids: Particle Design – Materials and Natural Products Processing, Antibes/Juan-les-Pins, France, 2000

  • Zetzl, C., Peper, S., Johannsen, M., Brunner, G., Benkedda, J., Barth, D., Viriot, M. L., Nicoud, R. M.
    Coupling of photoisomerization and supercritical fluid chromatography for developing a new integrated simulated moving bed reactor (Lecture)
    7th Meeting on Supercritical Fluids: Particle Design – Materials and Natural Products Processing, Antibes/Juan-les-Pins, France, 2000

  • Johannsen, M., Peper, S., Depta, A., Giese, T., Brunner, G.
    SMB-SFC for isomer separation (Lecture)
    8th International Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA), Zurich, Switzerland, 2000

  • Johannsen, M., Depta, A., Giese, T., Brunner, G.
    Separation of Phytol Stereoisomers in a SFC-SMB Plant (Lecture)
    PREP ´99 – 12th International Symposium on Preparative/Process Chromatography & Related Techniques, , San Francisco, USA, 1999

  • Johannsen, M., Depta, A., Giese, T., Brunner, G.
    Separation of stereoisomers in a SMB-SFC plant - determination of isotherms and simulation
    Proc. International Meeting of the GVC-Fachausschuss Hochdruckverfahrenstechnik, Karlsruhe, Germany, 1999

  • Johannsen, M., Depta, A., Giese, T., Brunner, G.
    Separation of Stereoisomers in a SMB-SFC Plant (Lecture)
    CISP´99 – 5th Italian Conference on Supercritical Fluids and Their Applications, Garda, Italy, 1999

  • Johannsen, M., Brunner, G.
    Mathematical simulation of supercritical fluid chromatography (Poster)
    PREP ´96 – 6th International Symposium on Preparative and Industrial Chromatography and Related Techniques, Basle, Switzerland, 1996

  • Johannsen, M., Brunner, G.
    Determination of thermodynamic data with on-line PSFC: Measurement and correlation of solubilities (Invited Lecture)
    7th International Symposium on Supercritical Fluid Chromatography and Extraction, Indianapolis, USA, 1996

  • Johannsen, M., Brunner, G.
    Investigations by SFC for characterization of SFE (Lecture)
    3rd European Symposium on Analytical Supercritical Fluid Chromatography and Extraction and the 6th International Symposium on Supercritical Fluid Chromatography and Extraction, Uppsala, Sweden, 1995

  • Johannsen, M., Brunner, G
    A supercritical fluid chromatographic system for investigations of solubilities and retention behaviour (Poster)
    Proceedings of the 5th International Symposium on Supercritical Fluid Chromatography and Extraction, Baltimore, USA, 1994

  • Johannsen, M., Brunner, G
    Apparatus for quick and accurate determination of solubilities in supercritical fluids. Solubilities of xanthines in supercritical carbon dioxide/methanol mixtures (Lecture)
    Proceedings of the 3rd International Symposium on Supercritical Fluid, Strasbourg, France, 1994

  • Johannsen, M., Brunner, G.
    A supercritical fluid chromatographic system for investigations of solubilities and retention behaviour (Poster)
    Book of Abstracts of the 17th International Symposium on Column Liquid Chromatography, Hamburg, Germany, 1993

Theses

Johannsen, M.  2004
Chromatographie mit überkritischen Gasen
Habilitation Technische Universität Hamburg-Harburg, Mensch & Buch Verlag: Berlin

Johannsen, M., 1995
Experimentelle Untersuchungen und Korrelierung des Löseverhaltens von Naturstoffen in überkritischem Kohlendioxid
Dissertation Technische Universität Hamburg-Harburg

Johannsen, M., 1990
Die Bestimmung nat. Vitamin K1-Gehalte in Ölen und ölreichen Samen mittels HPLC
Diplomarbeit Universität Hamburg

Reports

Kern, J., Johannsen, M. 2013
Nanoporöse Hohlkugeln zur Herstellung enantiomerenreiner Wirkstoffe und deren direkte Überführung in funktionsoptimierte Darreichungsformen - Teilprojekt: Selektive Adsorption und Enantiomerentrennung
Arbeitsbericht zum DFG-Forschungsvorhaben Jo 339/7-1

Johannsen, M. 2010
Abschlussbericht zum DFG-Forschungsvorhaben Jo 339/5-2 (Heisenbergstipendium)

Chuang, M.-H., Johannsen, M., 2008
Multikomponenten-Adsorptionsgleichgewichte aus unter- und überkritischen Lösungen
Arbeitsbericht zum DFG-Forschungsvorhaben Jo 339/6-1

Bezold, A., Johannsen, M., Brunner, G., 2005
Adsorptionsgleichgewichte in Zwei- oder Mehrkomponentensystemen unter erhöhten Drücken
Abschlussbericht zum DFG-Forschungsvorhaben Br 846/20-1/2

Lübbert, M., Johannsen, M., Brunner, G., 2003
Multikomponenten-Adsorptionsgleichgewichte aus unter- und überkritischen Lösungen
Abschlussbericht zum DFG-Forschungsvorhaben Jo 339/1-2

Johannsen, M., 2003
Reindarstellung chiraler Substanzen mittels präparativer Chromatographie mit überkritischem Kohlendioxid
Arbeitsbericht zum DFG-Forschungsvorhaben Jo 339/2-2

Johannsen, M., 2001
Reindarstellung chiraler Substanzen mittels präparativer Chromatographie mit überkritischem Kohlendioxid
Arbeitsbericht zum DFG-Forschungsvorhaben Jo 339/2-1

Lübbert, M., Johannsen, M., Brunner, G., 2000
Adsorptionsgleichgewichte in Zwei- oder Mehrkomponentensystemen unter erhöhten Drücken
Arbeitsbericht zum DFG-Forschungsvorhaben Jo 339/1-1

Johannsen, M., Brunner, G., 1996
Fluidchromatographische Untersuchungen zur Charakterisierung der Gasextraktion (SFE) aus Feststoffen
Abschlussbericht zum DFG-Forschungsvorhaben Br 846/9-2

Johannsen, M., Brunner, G., 1993
Fluidchromatographische Untersuchungen zur Charakterisierung der Gasextraktion (SFE) aus Feststoffen
Arbeitsbericht zum DFG-Forschungsvorhaben Br 846/9-1