@inproceedings{pmlr-v227-behrendt24a,
Author = {F. Behrendt and D. Bhattacharya and J. Krüger and R. Opfer and  A. Schlaefer},
Title = {Patched Diffusion Models for Unsupervised Anomaly Detection in Brain MRI.},
Year = {(2024).},
Volume = {<strong>227</strong>.},
Pages = {1019-1032},
Month = {10-12 Jul},
Editor = {In Oguz, Ipek and Noble, Jack and Li, Xiaoxiao and Styner, Martin and Baumgartner, Christian and Rusu, Mirabela and Heinmann, Tobias and Kontos, Despina and Landman, Bennett and Dawant, Benoit (Eds.)},
Publisher = {PMLR:},
Series = {Proceedings of Machine Learning Research},
Booktitle = {<em>Medical Imaging with Deep Learning</em>},
Url = {https://proceedings.mlr.press/v227/behrendt24a.html},
Abstract = {The use of supervised deep learning techniques to detect pathologies in brain MRI scans can be challenging due to the diversity of brain anatomy and the need for annotated data sets. An alternative approach is to use unsupervised anomaly detection, which only requires sample-level labels of healthy brains to create a reference representation. This reference representation can then be compared to unhealthy brain anatomy in a pixel-wise manner to identify abnormalities. To accomplish this, generative models are needed to create anatomically consistent MRI scans of healthy brains. While recent diffusion models have shown promise in this task, accurately generating the complex structure of the human brain remains a challenge. In this paper, we propose a method that reformulates the generation task of diffusion models as a patch-based estimation of healthy brain anatomy, using spatial context to guide and improve reconstruction. We evaluate our approach on data of tumors and multiple sclerosis lesions and demonstrate a relative improvement of 25.1% compared to existing baselines.}
}

@COMMENT{Bibtex file generated on 2026-5-16 with typo3 si_bibtex plugin. Data from https://www.tuhh.de/mtec/publications/2024-2020 }