Ingrid Haase, M.Sc.

Eißendorfer Str. 38, Building O, Room 3.018

Telephone +49 40 42878-4332

E-Mail: Ingrid Haase, M.Sc.


Large Scale Bioreactors – Insight Into a Black Box


In any case of mammalian cell expression systems it is of vital importance to ensure ideal growth conditions. In general, to achieve high product qualities and efficiencies, a constant feed and oxygen supply and a homogeneous mixing behavior have to be guaranteed during the entire process time as well as overall upstream processes. For a reliable design and scale up a profound understanding of hydrodynamics and mass transfer is required.

At the Institute of Multiphase Flows (IMS) at the Hamburg University of Technology various studies have been performed to study the influence of different operation conditions as well as stirrer geometries on mixing efficiency, mass transfer performance and power input on laboratory (0.002 and 0.03 m3) and industrial scale (15 m3). This work gives deep insights into the hydrodynamic behavior and a characterization of an industrial scale aerated stirred tank reactor."