Ingrid Haase, M.Sc.

Eißendorfer Str. 38

Building O, Room 3.018

21073 Hamburg

Phone +49 40 42878 - 4332

Mail Ingrid Haase


Large Scale Bioreactors – Insight Into a Black Box

In bioprocess engineering, the production of antibody medicine by means of mammalian cell cultures is of great relevance. To ensure optimal cell growth conditions for high product qualities and efficiencies, the cells must continuously be supplied with nutrients and dissolved oxygen. During the entire process, a homogeneous mixing behavior have to be guaranteed, which can be achieved by applying bioreactors like stirred tank reactors. For a reliable design and scale up of the bioreactor, a profound understanding of hydrodynamics and mass transfer is required.

At the Institute of Multiphase Flows (IMS) at the Hamburg University of Technology various studies have been performed to study the influence of different operation conditions as well as stirrer geometries on mass transfer performance, power input and mixing efficiency on laboratory scale (3 L) over pilot-scale (30 L) to industrial scale (15,000 L). This work gives deep insights into the hydrodynamic behavior and a characterization of an industrial scale aerated stirred tank reactor.


Graduate Teaching Assistant

  • Fundamentals of Fluid Mechanics (Fluid Mechanics I)

  • Fluid Mechanics in Process Engineering (Fluid Mechanics II)

Supervised Theses

  • Numerical investigation of the influence of selected stirrer variations on the flow behaviour within a stirred tank reactor, B. Salli, Bachelor thesis, 2023

  • Experimental investigation of mass transfer coefficient of oxygen by means of dynamic pressure method in an aerated 35 L stirred tank reactor, L. Hübenbecker, Bachelor thesis, 2022

Oral and Poster Presentation
  • I. Haase, J. Fitschen, M. Kuschel, T. Wucherpfennig, M. Schlüter: "Enhanced Mass Transfer Performance of Aerated Stirred Tank Reactors by Modification of the Standard Rushton Turbine", 11th International Conference on Multiphase Flow (ICMF), poster presentation, 2023

  • I. Haase, L. Hübenbecker, J. Fitschen, S. Orvalho, M. Zednikova, M. Schlüter: "Determination of Volumetric Mass Transfer Coefficient kLa by Means of Dynamic Pressure Method in an Aerated Stirred Tank Reactor", 4th International Symposium on Multiscale Multiphase Process Engineering (MMPE), poster presentation, 2022

  • I. Haase, J. Fitschen, S. Orvalho, M. Zednikova, M. Schlüter: "Determination of Volumetric Mass Transfer Coefficients kLa in Aerated Stirred Tank Reactor and Bubble Column by Means of the Dynamic Pressure Method", 26th International Congress of Chemical and Process Engineering (CHISA), oral presentation, 2022