PD Dr. habil. Monika Johannsen
Eißendorfer Str. 38, Building O, Room 1.012
Telephone +49 40 42878-4260
E-Mail: PD Dr. habil. Monika Johannsen.
- Chromatographic Separation Processes (Modul "Separation Technologies for Life Science")
- Advanced Separation Processes (Modul "High Pressure Chemical Engineering")
|Title: Separation of enantiomers of Ibuprofen on chiral stationary phases by packed column supercritical fluid chromatography|
|Written by: Johannsen, M.|
|in: Journal of Chromatography A 2001|
|Volume: 937 Number:|
|on pages: 135 - 138|
|Publisher: Elsevier B.V.|
|Institution: Institute of Thermal Separation Processes, Hamburg University of Technology, Eißendorfer Straße 38, 21073 Hamburg, Germany|
Abstract: A packed column supercritical fluid chromatography (SFC) method for the separation of ibuprofen enantiomers on a chiral stationary phase and CO2 with modifier as mobile phase has been developed at an analytical scale. Among 11 different stationary phases the Kromasil CHI-TBB phase showed by far the best separation properties. The influence of different modifiers, injection solvents, temperature, and pressure, and density of the fluid, respectively, on the separation behavior has been studied. It was found that the separation behavior strongly depends on the type of modifier and the modifier content. Temperature and pressure are of less influence.