PD Dr. habil. Monika Johannsen
Eißendorfer Str. 38, Building O, Room 1.012
Telephone +49 40 42878-4260
E-Mail: PD Dr. habil. Monika Johannsen.
- Chromatographic Separation Processes (Modul "Separation Technologies for Life Science")
- Advanced Separation Processes (Modul "High Pressure Chemical Engineering")
|Title: Enantioseparation of 1-phenyl-1-propanol by supercritical fluid-simulated moving bed chromatography|
|Written by: Rajendran, A., Peper, S., Johannsen, M., Mazzotti, M., Morbidelli, M., Brunner, G.|
|in: Journal of Chromatography A 2005|
|Volume: 1092 (1) Number:|
|on pages: 55-64|
|Publisher: Elsevier B.V.|
|Institution: Institute of Thermal Separation Processes, Hamburg University of Technology, Eißendorfer Straße 38, 21073 Hamburg, Germany|
Abstract: The enantioseparation of 1-phenyl-1-propanol through the supercritical fluid-simulated moving bed (SF-SMB) process is studied. Non-linear isotherms were measured on an analytical column, and used together with the triangle theory for SMB design to select operating conditions for the SF-SMB. Experiments were carried out on a pilot-scale SF-SMB plant at conditions that corresponded to the non-linear range of the isotherm. Under conditions of low feed concentration, complete separation (extract purity?=?99.5%; raffinate purity?=?98.4%) was achieved. Under conditions of larger feed concentration, the best separation corresponded to an extract purity of 98.0% and a raffinate purity of 94.0%, and yielded a productivity of 110?g of racemate per kg stationary phase per day.