PD Dr. habil. Monika Johannsen
Eißendorfer Str. 38, Building O, Room 1.012
Telephone +49 40 42878-4260
E-Mail: PD Dr. habil. Monika Johannsen.
- Chromatographic Separation Processes (Modul "Separation Technologies for Life Science")
- Advanced Separation Processes (Modul "High Pressure Chemical Engineering")
|Title: Management and Control of Modifier Content in preparative SFC Solvent Cycles|
|Written by: Kaemmerer, H., Brunner, G., Johannsen, M.|
|in: Journal of Supercritical Fluids 2007|
|Volume: 43(2) Number:|
|on pages: 204-213|
|Publisher: Elsevier B.V.|
|Institution: Hamburg University of Technology, Eissendorfer Strasse 38, D-21073 Hamburg, Germany|
Abstract: The objective of this work was to establish a solvent cycle with a possibility for modifier control in a preparative supercritical fluid chromatography simulated moving bed plant (SFC-SMB). Fourier transform infrared (FTIR) spectroscopy and flame ionization detection (FID) have been investigated for measuring alcohol concentrations in supercritical carbon dioxide. The integration of these in-line techniques into a modifier control schema allowed the operation of a closed loop SFC-SMB cycle. The applicability of the developed control concept for usage of 2-propanol in supercritical carbon dioxide has been verified by an experimental test series involving an eight column SFC-SMB plant. Different process variations have been compared in terms of energy and solvent consumption. Hereby, savings of almost all CO2 and 76% modifier could be achieved.