PD Dr. habil. Monika Johannsen

Eißendorfer Str. 38, Building O, Room 1.012

Telephone +49 40 42878-4260

E-Mail: PD Dr. habil. Monika Johannsen.


Education

  • Chromatographic Separation Processes (Modul "Separation Technologies for Life Science")
  • Advanced Separation Processes (Modul "High Pressure Chemical Engineering")


Publications

[135537]
Title: Management and Control of Modifier Content in preparative SFC Solvent Cycles
Written by: Kaemmerer, H., Brunner, G., Johannsen, M.
in: Journal of Supercritical Fluids 2007
Volume: 43(2) Number:
on pages: 204-213
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Publisher: Elsevier B.V.
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Institution: Hamburg University of Technology, Eissendorfer Strasse 38, D-21073 Hamburg, Germany
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DOI: 10.1016/j.supflu.2007.02.011
URL: https://www.deepdyve.com/lp/elsevier/management-and-control-of-modifier-content-in-preparative-sfc-solvent-LMJgGpbzK1
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[doi] [www] [BibTex]

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Abstract: The objective of this work was to establish a solvent cycle with a possibility for modifier control in a preparative supercritical fluid chromatography simulated moving bed plant (SFC-SMB). Fourier transform infrared (FTIR) spectroscopy and flame ionization detection (FID) have been investigated for measuring alcohol concentrations in supercritical carbon dioxide. The integration of these in-line techniques into a modifier control schema allowed the operation of a closed loop SFC-SMB cycle. The applicability of the developed control concept for usage of 2-propanol in supercritical carbon dioxide has been verified by an experimental test series involving an eight column SFC-SMB plant. Different process variations have been compared in terms of energy and solvent consumption. Hereby, savings of almost all CO2 and 76% modifier could be achieved.