PD Dr. habil. Monika Johannsen
Eißendorfer Str. 38, Building O, Room 1.012
Telephone +49 40 42878-4260
E-Mail: PD Dr. habil. Monika Johannsen.
- Chromatographic Separation Processes (Modul "Separation Technologies for Life Science")
- Advanced Separation Processes (Modul "High Pressure Chemical Engineering")
|Title: Influence of chemical nature of carrier materials on the dissolution behavior of racemic ibuprofen|
|Written by: Reiser, S., Sun, M., Johannsen, M., Türk, M.|
|in: The Journal of Supercritical Fluids 2018|
|Volume: 132 Number:|
|on pages: 91–98|
|Publisher: Elsevier B.V.|
|Institution: Hamburg University of Technology, Eissendorfer Strasse 38, D-21073 Hamburg, Germany|
Abstract: The poor aqueous solubility of ibuprofen due to its hydrophobicity limits the bioavailability of the drug in the aqueous environment of the human body. Therefore particle deposition experiments were performed with ibuprofen and different carrier materials. Furthermore, the dissolution behavior of the untreated ibuprofen and the ibuprofen loaded carriers has been investigated at 310 K and pH = 2.0 and pH = 5.5. The results of this investigation demonstrate that drug loadings up to 50 wt% drug onto silica materials could be achieved and that the drug loading increases nearly linear with increasing surface area of the silica materials. Furthermore, the study reveals that the highest dissolution rate was obtained with ?-cyclodextrin and that the dissolution rate of all materials investigated increases with increasing pHvalue.