Dipl.-Ing. Annika Rosseburg

Group leader: "Transport Processes in Bioreactors"

Am Irrgarten 7, Building Q, Room 119
21073 Hamburg
Tel.:+49 40 42878-4662
Mail: annika.rosseburg(at)tuhh.de


Research

Aerated stirred tank reactors are widely used in chemical and pharmaceutical industry. However, the complex two phase flows are still not completely understood and the prediction is still challenging despite the intensive investigations during the last decades.  To improve the reliability of the models and scale ups, global and local information about for instance the flow structure and the bubble size distributions are of great importance. The measurement of this local information on the other hand is very challenging especially in large scale systems, because optical investigations are crucial. 

To overcome this problem a transparent stirred tank reactor on industrial scale has been erected at the Hamburg University of Technology in cooperation with Boehringer Ingelheim Pharma GmbH & Co.KG.

Current Research:

With the Acrylic Glass Reactor measurement of local and global flow structure, bubble size distribution, gas hold-up and mixing can be conducted and be compared with the small scale reactors.

Industrial Application:

A new magnetic mounted agitator has been successfully tested in the Acrylic Glass Reactor and will be installed at the new facility of Boehringer Ingelheim in Wien.

Zeta erhält Großauftrag für Bioreaktoren von Boehringer Ingelheim

 

Edducation at the Acrylic Glass Reactor:

“How can medicine be produced more efficient and safe in the future?”

This is the question which was addressed by the first ContinuING program at the IMS in 2017. Theoretical lessons and experimental training were combined in the three-day-program made for participants of the pharmaceutical industry to give a deeper understanding into the processes of an aerated stirred tank, that are usually hidden behind the steel walls of the industrial fermenters. 

Education at TUHH (until 2017):

Assistance of undergraduate courses: Fluid Mechanics for Process Engineering 

Assistance of graduate courses: Applications of Fluid Mechanics in Process Engineering 


 

Supervised Theses:

  • "Experimentelle Analyse des Stoffdurchganges zweiphasiger Systeme in begasten Rührkesselreaktoren“ Jürgen Fitschen, Juli 2017
  • "Entwicklung und Implementierung einer Messmethode zur Bestimmung des Stofftransportkoeffizienten unter stationären Bedingungen“ Sebastian Nichtern, September 2017
  • „Gegenüberstellung unterschiedlicher Methoden zur Ermittlung der spezifischen Phasengrenzfläche im Labor- und Industriemaßstab“, Vanessa Berg, September 2016
  • „Bestimmung und Vergleich der Blasengrößenverteilung in begasten Rührreaktoren im Labor- und Industriemaßstab unter Variation wichtiger Prozessparameter“, Daniela Sanders, September 2016
  • „Untersuchung des Einflusses von blasenzerteilenden Gittern sowie unregelmäßigem Rühren auf den Stofftransport in begasten Rührreaktoren“, Tim Kuczynski, June 2016
  • „Optimierung und Anwendung der Auswertemethodik zur Bestimmung des volumetrischen Stoffübergangskoeffizienten in begasten Rührreaktionen“, Birger Niclas, June 2016
  • „Untersuchungen zu Phasengrenzfläche und Stofftransport für verschiedene Konfigurationen eines 
  • Single-Use Bioreaktors“, Marc Maly, November 2015
  • „Untersuchung des Einflusses von unterschiedlichen Rührwerken und Begasungsraten auf die Mischzeit eines 2 L Rührreaktors“, Khatera Sadat, October 2015
  • „Xanthan Gum aqueous solution: Rheological properties and influence of non-ionic surfactant addition”, Álvaro Guijarro Miravalles, April 2014
  • „Rheologische Charakterisierung von Fermentationsbrühen zur Entwicklung von Modellfluiden“, Christine Kloock, December 2013
  • „Bestimmung der Blasengrößenverteilungin Modellmedien von Fermentationsbrühen“, Leonhard Parakenings, Oktober 2013


 

Publications: 

Rosseburg, A.; Fitschen, J.; Wutz, J.; Wucherpfennig, T.; Schlüter, M.: Hydrodynamic inhomogeneities in large scale stirred tanks – Influence on mixing time,Chemical Engineering Science, 2018, 188, 208-220, DOI: 10.1016/j.ces.2018.05.008

Rosseburg, A., Fitschen, J., Wutz, J., Wucherpfennig, T., Schlüter, M., „Influence of local flow structure on the mixing behaviour within an aerated 12 000L stirred tank reactor”, Jahrestreffen der ProcessNet Fachgruppe Mischvorgänge, Munich 2018, Germany

Rosseburg,A.; Schäfer, J.-E.; Wucherpfennig,T.; Berger,M.; Schlüter, M. “Investigation of local mixing and bubble size distribution in a stirred bubble column reactor”, 9th International Conference on Multiphase Flows, Firenze 2016, Italy