@article{Exner2019_3DPrinted,
Author = {M. Exner, P. Szwargulski, P. Ludewig, T. Knopp and M. Graeser},
Title = {3D Printed Anatomical Model of a Rat for Medical Imaging.},
Journal = {<em>Current Directions in Biomedical Engineering</em>.},
Year = {(2019).},
Volume = {<strong>5</strong>.},
Number = {(1),},
Pages = {187-190},
Note = {article, 3Dprinting, hardware},
Doi = {10.1515/cdbme-2019-0048.},
Keywords = {Rat Model, Magnetic Particle Imaging, 3D
Printing},
Abstract = {For medical research, approximately 115 million
animals are needed every year. Rodents are used to test
possible applications and procedures for the diagnosis of
anatomical and physiological diseases. However, working
with living animals increases the complexity of an
experiment. Accurate experimental planning is essential in
order to fulfill the 3R rules (replace, reduce and refine).
Especially in tracer-based imaging modalities, such as
magnetic particle imaging (MPI), where only nanoparticles
give a positive contrast, the anatomical structure of the rodent
is not visible without co-registration with another imaging
modality. This leads to problems in the experimental
planning, as parameters, such as field of view, rodent
position and tracer concentration, have to be determined
without visual feedback. In this work, a 3D CAD rat model is
presented, which can be used to improve the experiment
planning and thus reduce the number of animals required. It
was determined using an anatomy atlas and 3D printed with
stereolithography. The resulting model contains the most
important organs and vessels as hollow cavities. By filling
these with appropriate tracer materials, the phantom can be
used in different imaging modalities such as MPI, magnetic
resonance imaging (MRI) or computed tomography (CT). In
a first MPI measurement, the phantom was filled with
superparamagnetic nanoparticles. Finally, a successful
visualization of all organs and vessels of the phantom was
possible. This enables the planning of the experiment and the
optimization of experimental parameters for a region of
interest, where certain organs in a living animal are localized}
}

@COMMENT{Bibtex file generated on 2026-5-14 with typo3 si_bibtex plugin. Data from https://www.tuhh.de/ibi/publications }