Prof. Dr.-Ing. Tobias Knopp

Universitätsklinikum Hamburg-Eppendorf (UKE)
Sektion für Biomedizinische Bildgebung
Lottestraße 55
2ter Stock, Raum 209
22529 Hamburg
Tel.: 040 / 7410 56794
Fax: 040 / 7410 45811
E-Mail: t.knopp(at)uke.de

Technische Universität Hamburg (TUHH)
Institut für Biomedizinische Bildgebung
Gebäude E, Raum 4.044
Am Schwarzenberg-Campus 3
21073 Hamburg
E-Mail: tobias.knopp(at)tuhh.de

 

 

Roles

  • Head of the Institute for Biomedical Imaging
  • Editor-in-chief of the International Journal on Magnetic Particle Imaging (IJMPI)

Consulting Hours

  • On appointment

Research Interests

  • Tomographic Imaging
  • Image Reconstruction
  • Signal- and Image Processing
  • Magnetic Particle Imaging

Curriculum Vitae

Tobias Knopp received his Diplom degree in computer science in 2007 and his PhD in 2010, both from the University of Lübeck with highest distinction. For his PHD on the tomographic imaging method Magnetic Particle Imaging (MPI) he was awarded with the Klee award from the DGBMT (VDE) in 2011. From 2010 until 2011 he led the MAPIT project at the University of Lübeck and published the first scientific book on MPI. In 2011 he joined Bruker Biospin to work on the first commercially available MPI system. From 2012 until 2014 he worked at Thorlabs in the field of Optical Coherence Tomography (OCT) as a software developer. In 2014 he has been appointed as Professor for experimental Biomedical Imaging at the University Medical Center Hamburg-Eppendorf and the Hamburg University of Technology.

Publications

[134634]
Title: Simultaneous Magnetic Particle Imaging and Navigation of large superparamagnetic nanoparticles in bifurcation flow experiments
Written by: F. Griese, T. Knopp, C. Gruettner, F. Thieben, K. Müller, S. Loges, P. Ludewig, N. Gdaniec
in: Journal of Magnetism and Magnetic Materials 3 2020
Volume: 498 Number:
on pages: 166206
Chapter:
Editor:
Publisher:
Series:
Address:
Edition:
ISBN:
how published:
Organization:
School:
Institution:
Type:
DOI: https://doi.org/10.1016/j.jmmm.2019.166206
URL: https://www.sciencedirect.com/science/article/pii/S0304885319320372?utm_campaign=STMJ_75273_AUTH_SERV_PPUB&utm_medium=email&utm_dgroup=Email1Publishing&utm_acid=208010593&SIS_ID=-1&dgcid=STMJ_75273_AUTH_SERV_PPUB&CMX_ID=&utm_in=DM620455&utm_source=AC_30&u
ARXIVID:
PMID:

[doi] [www] [BibTex]

Note: article

Abstract: Magnetic Particle Imaging (MPI) has been successfully used to visualize the distribution of superparamagnetic nanoparticles within 3D volumes with high sensitivity in real time. Since the magnetic field topology of MPI scanners is well suited for applying magnetic forces on particles and micron-sized ferromagnetic devices, MPI has been recently used to navigate micron-sized particles and micron-sized swimmers. In this work, we analyze the magnetophoretic mobility and the imaging performance of two different particle types for Magnetic Particle Imaging/Navigation (MPIN). MPIN constantly switches between imaging and magnetic modes, enabling quasi-simultaneous navigation and imaging of particles. We determine the limiting flow velocity to be 8.18 mL/s using a flow bifurcation experiment, that allows all particles to flow only through one branch of the bifurcation. Furthermore, we have succeeded in navigating the particles through the branch of a bifurcation phantom narrowed by either 60% or 100% stenosis, while imaging their accumulation on the stenosis. The particles in combination with therapeutic substances have a high potential for targeted drug delivery and could help to reduce the dose and improve the efficacy of the drug, e.g. for specific tumor therapy and ischemic stroke therapy.