Patryk Szwargulski, M.Sc.
Universitätsklinikum Hamburg-Eppendorf (UKE)
Sektion für Biomedizinische Bildgebung
2ter Stock, Raum 203
Technische Universität Hamburg (TUHH)
Institut für Biomedizinische Bildgebung
Gebäude E, Raum 4.044
Am Schwarzenberg-Campus 3
- Magnetic Particle Imaging
- Image Reconstruction
- Signal and Image Processing
In 2015 Patryk Szwargulski graduated with a master's degree thesis on Fast Reconstruction of Magnetic Particle Imaging Data using the Focusfields. Currently he is a PhD student in the group of Tobias Knopp for experimental Biomedical Imaging at the University Medical Center Hamburg-Eppendorf and the Hamburg University of Technology.
|Title: Development of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapment into human erythrocytesDevelopment of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapm|
|Written by: A. Antonelli, P. Szwargulski, E. S. Scarpa, F. Thieben, C. Grüttner, G. Ambrosi, L. Guidi, P. Ludewig, T. Knopp and M. Magnani|
|in: Nanomedicine April 2020|
|Volume: 15 Number: 8|
|on pages: 739-753|
|Publisher: Future Medicine Ltd|
Abstract: Aim: Magnetic particle imaging (MPI) is highly promising for biomedical applications, but optimal tracers for MPI, namely superparamagnetic iron oxide-based contrast agents, are still lacking. Materials & methods: The encapsulation of commercially available nanoparticles, specifically synomag®-D and perimag®, into human red blood cells (RBCs) was performed by a hypotonic dialysis and isotonic resealing procedure. The amounts of superparamagnetic iron oxide incorporated into RBCs were determined by Fe quantification using nuclear magnetic resonance and magnetic particle spectroscopy. Results: Perimag-COOH nanoparticles were identified as the best nanomaterial for encapsulation in RBCs. Perimag-COOH-loaded RBCs proved to be viable cells showing a good magnetic particle spectroscopy performance, while the magnetic signal of synomag-D-COOH-loaded RBCs dropped sharply. Conclusion: Perimag-COOH-loaded RBCs could be a potential tool for MPI diagnostic applications.