Dr.-Ing. Matthias Gräser

Universitätsklinikum Hamburg-Eppendorf (UKE)
Sektion für Biomedizinische Bildgebung
Lottestraße 55
2ter Stock, Raum 212
22529 Hamburg

Technische Universität Hamburg (TUHH)
Institut für Biomedizinische Bildgebung
Gebäude E, Raum 4.044
Am Schwarzenberg-Campus 3
21073 Hamburg

Tel.: 040 / 7410 25812
E-Mail: matthias.graeser(at)tuhh.de
E-Mail: ma.graeser(at)uke.de

Research Interests

  • Magnetic Particle Imaging
  • Low Noise Electronics
  • Inductive Sensors
  • Passive Electrical Devices

Curriculum Vitae

Matthias Gräser submitted his Dr.-Ing. thesis in january 2016 at the institute of medical engineering (IMT) at the university of Lübeck and is now working as a Research Scientist at the institute for biomedical imaging (IBI) at the technical university in Hamburg, Germany.  Here he develops concepts for Magnetic-Particle-Imaging (MPI) devices. His main aim is to improve the sensitivity of the imageing devices and improve resolution and application possibilities of MPI technology.

In 2011 Matthias Gräser started to work at the IMT as a Research Associate in the Magnetic Particle Imaging Technology (MAPIT) project. In this project he devolped the analog signal chains for a rabbit sized field free line imager. Additionally he developed a two-dimensional Magnetic-Particle-Spectrometer. This device can apply various field sequences and measure the particle response with a very high signal-to-noise ratio (SNR).

The dynamic behaviour of magnetic nanoparticles is still not fully understood. Matthias Gräser investigated the particle behaviour by modeling the particle behaviour with stochastic differential equations. With this model it is possible to simulate the impact of several particle parameters and field sequences on the particle response .

In 2010 Matthias Gräser finished his diploma at the Karlsruhe Institue of Technology (KIT). His diploma thesis investigated the nerve stimulation of magnetic fields in the range from 4 kHz to 25 kHz.

Journal Publications

[76907]
Title: Magnetic particle imaging: current developments and future directions.
Written by: N. Panagiotopoulos, R. L. Duschka, M. Ahlborg, G. Bringout, C. Debbeler, M. Graeser, C. Kaethner, K. Lüdtke-\-Buzug, H. Medimagh, J. Stelzner, T. M. Buzug, J. Barkhausen, F. M. Vogt J. Haegele
in: <em>International Journal of Nanomedicine</em>. (2015).
Volume: <strong>10</strong>. Number:
on pages: 3097--3114
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DOI: 10.2147/IJN.S70488
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ARXIVID:
PMID: 25960650

[BibTex] [pmid]

Note: article

Abstract: Magnetic particle imaging ({MPI}) is a novel imaging method that was first proposed by Gleich and Weizenecker in 2005. Applying static and dynamic magnetic fields, {MPI} exploits the unique characteristics of superparamagnetic iron oxide nanoparticles ({SPIONs}). The {SPIONs}' response allows a three-dimensional visualization of their distribution in space with a superb contrast, a very high temporal and good spatial resolution. Essentially, it is the {SPIONs}' superparamagnetic characteristics, the fact that they are magnetically saturable, and the harmonic composition of the {SPIONs}' response that make {MPI} possible at all. As {SPIONs} are the essential element of {MPI}, the development of customized nanoparticles is pursued with the greatest effort by many groups. Their objective is the creation of a {SPION} or a conglomerate of particles that will feature a much higher {MPI} performance than nanoparticles currently available commercially. A particle's {MPI} performance and suitability is characterized by parameters such as the strength of its {MPI} signal, its biocompatibility, or its pharmacokinetics. Some of the most important adjuster bolts to tune them are the particles' iron core and hydrodynamic diameter, their anisotropy, the composition of the particles' suspension, and their coating. As a three-dimensional, real-time imaging modality that is free of ionizing radiation, {MPI} appears ideally suited for applications such as vascular imaging and interventions as well as cellular and targeted imaging. A number of different theories and technical approaches on the way to the actual implementation of the basic concept of {MPI} have been seen in the last few years. Research groups around the world are working on different scanner geometries, from closed bore systems to single-sided scanners, and use reconstruction methods that are either based on actual calibration measurements or on theoretical models. This review aims at giving an overview of current developments and future directions in {MPI} about a decade after its first appearance.

Conference Proceedings

[76907]
Title: Magnetic particle imaging: current developments and future directions.
Written by: N. Panagiotopoulos, R. L. Duschka, M. Ahlborg, G. Bringout, C. Debbeler, M. Graeser, C. Kaethner, K. Lüdtke-\-Buzug, H. Medimagh, J. Stelzner, T. M. Buzug, J. Barkhausen, F. M. Vogt J. Haegele
in: <em>International Journal of Nanomedicine</em>. (2015).
Volume: <strong>10</strong>. Number:
on pages: 3097--3114
Chapter:
Editor:
Publisher:
Series:
Address:
Edition:
ISBN:
how published:
Organization:
School:
Institution:
Type:
DOI: 10.2147/IJN.S70488
URL:
ARXIVID:
PMID: 25960650

[BibTex] [pmid]

Note: article

Abstract: Magnetic particle imaging ({MPI}) is a novel imaging method that was first proposed by Gleich and Weizenecker in 2005. Applying static and dynamic magnetic fields, {MPI} exploits the unique characteristics of superparamagnetic iron oxide nanoparticles ({SPIONs}). The {SPIONs}' response allows a three-dimensional visualization of their distribution in space with a superb contrast, a very high temporal and good spatial resolution. Essentially, it is the {SPIONs}' superparamagnetic characteristics, the fact that they are magnetically saturable, and the harmonic composition of the {SPIONs}' response that make {MPI} possible at all. As {SPIONs} are the essential element of {MPI}, the development of customized nanoparticles is pursued with the greatest effort by many groups. Their objective is the creation of a {SPION} or a conglomerate of particles that will feature a much higher {MPI} performance than nanoparticles currently available commercially. A particle's {MPI} performance and suitability is characterized by parameters such as the strength of its {MPI} signal, its biocompatibility, or its pharmacokinetics. Some of the most important adjuster bolts to tune them are the particles' iron core and hydrodynamic diameter, their anisotropy, the composition of the particles' suspension, and their coating. As a three-dimensional, real-time imaging modality that is free of ionizing radiation, {MPI} appears ideally suited for applications such as vascular imaging and interventions as well as cellular and targeted imaging. A number of different theories and technical approaches on the way to the actual implementation of the basic concept of {MPI} have been seen in the last few years. Research groups around the world are working on different scanner geometries, from closed bore systems to single-sided scanners, and use reconstruction methods that are either based on actual calibration measurements or on theoretical models. This review aims at giving an overview of current developments and future directions in {MPI} about a decade after its first appearance.