Dr.-Ing. Matthias Gräser

Universitätsklinikum Hamburg-Eppendorf (UKE)
Sektion für Biomedizinische Bildgebung
Lottestraße 55
2ter Stock, Raum 212
22529 Hamburg

Technische Universität Hamburg (TUHH)
Institut für Biomedizinische Bildgebung
Gebäude E, Raum 4.044
Am Schwarzenberg-Campus 3
21073 Hamburg

Tel.: 040 / 7410 25812
E-Mail: matthias.graeser(at)tuhh.de
E-Mail: ma.graeser(at)uke.de

Research Interests

  • Magnetic Particle Imaging
  • Low Noise Electronics
  • Inductive Sensors
  • Passive Electrical Devices

Curriculum Vitae

Matthias Gräser submitted his Dr.-Ing. thesis in january 2016 at the institute of medical engineering (IMT) at the university of Lübeck and is now working as a Research Scientist at the institute for biomedical imaging (IBI) at the technical university in Hamburg, Germany.  Here he develops concepts for Magnetic-Particle-Imaging (MPI) devices. His main aim is to improve the sensitivity of the imageing devices and improve resolution and application possibilities of MPI technology.

In 2011 Matthias Gräser started to work at the IMT as a Research Associate in the Magnetic Particle Imaging Technology (MAPIT) project. In this project he devolped the analog signal chains for a rabbit sized field free line imager. Additionally he developed a two-dimensional Magnetic-Particle-Spectrometer. This device can apply various field sequences and measure the particle response with a very high signal-to-noise ratio (SNR).

The dynamic behaviour of magnetic nanoparticles is still not fully understood. Matthias Gräser investigated the particle behaviour by modeling the particle behaviour with stochastic differential equations. With this model it is possible to simulate the impact of several particle parameters and field sequences on the particle response .

In 2010 Matthias Gräser finished his diploma at the Karlsruhe Institue of Technology (KIT). His diploma thesis investigated the nerve stimulation of magnetic fields in the range from 4 kHz to 25 kHz.

Journal Publications

[164769]
Title: Design of a head coil for high resolution mouse brain perfusion imaging using magnetic particle imaging.
Written by: M. Graeser, P. Ludewig, P. Szwargulski, F. Foerger, T. Liebing, N. D. Forkert, F. Thieben, T. Magnus and T. Knopp
in: <em>Physics in Medicine and Biology</em>. (2020).
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on pages: 9
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DOI: 10.1088/1361-6560/abc09e
URL: https://arxiv.org/abs/2004.11728
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[www] [BibTex]

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Abstract: Magnetic Particle Imaging (MPI) is a novel and versatile imaging modality developing towards human application. When up-scaling to human size, the sensitivity of the systems naturally drops as the coil sensitivity depends on the bore diameter. Thus, new methods to push the sensitivity limit further have to be investigated to cope for this loss. In this paper a dedicated surface coil improving the sensitvity in cerebral imaging applications was developed. Similar to MRI the developed surface coil improves the sensitivity due to the closer vicinity to the region of interest. With the developed surface coil presented in this work, it is possible to image tracer samples containing only 896 pg iron and detect even small vessels and anatomical structures within a wild type mouse model. As current sensitivity measures are dependent on the tracer system a new method for determining a sensitivity measure without this dependence on the tracer is presented and verified to enable comparison between MPI receiver systems.

Conference Proceedings

[164769]
Title: Design of a head coil for high resolution mouse brain perfusion imaging using magnetic particle imaging.
Written by: M. Graeser, P. Ludewig, P. Szwargulski, F. Foerger, T. Liebing, N. D. Forkert, F. Thieben, T. Magnus and T. Knopp
in: <em>Physics in Medicine and Biology</em>. (2020).
Volume: Number:
on pages: 9
Chapter:
Editor:
Publisher:
Series:
Address:
Edition:
ISBN:
how published:
Organization:
School:
Institution:
Type:
DOI: 10.1088/1361-6560/abc09e
URL: https://arxiv.org/abs/2004.11728
ARXIVID:
PMID:

[www] [BibTex]

Note: article

Abstract: Magnetic Particle Imaging (MPI) is a novel and versatile imaging modality developing towards human application. When up-scaling to human size, the sensitivity of the systems naturally drops as the coil sensitivity depends on the bore diameter. Thus, new methods to push the sensitivity limit further have to be investigated to cope for this loss. In this paper a dedicated surface coil improving the sensitvity in cerebral imaging applications was developed. Similar to MRI the developed surface coil improves the sensitivity due to the closer vicinity to the region of interest. With the developed surface coil presented in this work, it is possible to image tracer samples containing only 896 pg iron and detect even small vessels and anatomical structures within a wild type mouse model. As current sensitivity measures are dependent on the tracer system a new method for determining a sensitivity measure without this dependence on the tracer is presented and verified to enable comparison between MPI receiver systems.