Dr.-Ing. Matthias Gräser

Universitätsklinikum Hamburg-Eppendorf (UKE)
Sektion für Biomedizinische Bildgebung
Lottestraße 55
2ter Stock, Raum 212
22529 Hamburg

Technische Universität Hamburg (TUHH)
Institut für Biomedizinische Bildgebung
Gebäude E, Raum 4.044
Am Schwarzenberg-Campus 3
21073 Hamburg

Tel.: 040 / 7410 25812
E-Mail: matthias.graeser(at)tuhh.de
E-Mail: ma.graeser(at)uke.de

Research Interests

  • Magnetic Particle Imaging
  • Low Noise Electronics
  • Inductive Sensors
  • Passive Electrical Devices

Curriculum Vitae

Matthias Gräser submitted his Dr.-Ing. thesis in january 2016 at the institute of medical engineering (IMT) at the university of Lübeck and is now working as a Research Scientist at the institute for biomedical imaging (IBI) at the technical university in Hamburg, Germany.  Here he develops concepts for Magnetic-Particle-Imaging (MPI) devices. His main aim is to improve the sensitivity of the imageing devices and improve resolution and application possibilities of MPI technology.

In 2011 Matthias Gräser started to work at the IMT as a Research Associate in the Magnetic Particle Imaging Technology (MAPIT) project. In this project he devolped the analog signal chains for a rabbit sized field free line imager. Additionally he developed a two-dimensional Magnetic-Particle-Spectrometer. This device can apply various field sequences and measure the particle response with a very high signal-to-noise ratio (SNR).

The dynamic behaviour of magnetic nanoparticles is still not fully understood. Matthias Gräser investigated the particle behaviour by modeling the particle behaviour with stochastic differential equations. With this model it is possible to simulate the impact of several particle parameters and field sequences on the particle response .

In 2010 Matthias Gräser finished his diploma at the Karlsruhe Institue of Technology (KIT). His diploma thesis investigated the nerve stimulation of magnetic fields in the range from 4 kHz to 25 kHz.

Journal Publications

[145079]
Title: Organ specific mouse head coil for improved image quality in magnetic particle imaging.
Written by: M. Graeser, T. Liebing, P. Szwargulski, F. Förger, F. Thieben, P. Ludewig, T. Knopp
in: <em>International Journal on Magnetic Particle Imaging</em>. (2020).
Volume: <strong>6</strong>. Number: (2),
on pages: 1-3
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DOI: 10.18416/IJMPI.2020.2009046
URL: https://journal.iwmpi.org/index.php/iwmpi/article/view/276
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[www] [BibTex]

Note: inproceedings

Abstract: Magnetic particle imaging is a very useful tool in the detection of stroke. To study the ability of stroke in a mouse model the data acquisition is challenging as a mouse brain contains only a very small ratio of blood compared to large animals or humans. The effective concentration within the whole organ is therefore very small, especially compared to the heart or the liver. Typical MPI receiver coils however cover a sensitive region of around 30 mm to 50 mm and have a bore size of above 40 mm. This leads on the one hand to non-optimal signal coupling due to the distance to the particles and on the other hand strong signals from the heart can cause artifacts in the low signal regions. In this work we present a coil optimized for mouse brain imaging, which due to its small size, also dampens signal from regions outside of the coil.

Conference Proceedings

[145079]
Title: Organ specific mouse head coil for improved image quality in magnetic particle imaging.
Written by: M. Graeser, T. Liebing, P. Szwargulski, F. Förger, F. Thieben, P. Ludewig, T. Knopp
in: <em>International Journal on Magnetic Particle Imaging</em>. (2020).
Volume: <strong>6</strong>. Number: (2),
on pages: 1-3
Chapter:
Editor:
Publisher:
Series:
Address:
Edition:
ISBN:
how published:
Organization:
School:
Institution:
Type:
DOI: 10.18416/IJMPI.2020.2009046
URL: https://journal.iwmpi.org/index.php/iwmpi/article/view/276
ARXIVID:
PMID:

[www] [BibTex]

Note: inproceedings

Abstract: Magnetic particle imaging is a very useful tool in the detection of stroke. To study the ability of stroke in a mouse model the data acquisition is challenging as a mouse brain contains only a very small ratio of blood compared to large animals or humans. The effective concentration within the whole organ is therefore very small, especially compared to the heart or the liver. Typical MPI receiver coils however cover a sensitive region of around 30 mm to 50 mm and have a bore size of above 40 mm. This leads on the one hand to non-optimal signal coupling due to the distance to the particles and on the other hand strong signals from the heart can cause artifacts in the low signal regions. In this work we present a coil optimized for mouse brain imaging, which due to its small size, also dampens signal from regions outside of the coil.