Dr.-Ing. Matthias Gräser

Universitätsklinikum Hamburg-Eppendorf (UKE)
Sektion für Biomedizinische Bildgebung
Lottestraße 55
2ter Stock, Raum 212
22529 Hamburg

Technische Universität Hamburg (TUHH)
Institut für Biomedizinische Bildgebung
Gebäude E, Raum 4.044
Am Schwarzenberg-Campus 3
21073 Hamburg

Tel.: 040 / 7410 25812
E-Mail: matthias.graeser(at)tuhh.de
E-Mail: ma.graeser(at)uke.de

Research Interests

  • Magnetic Particle Imaging
  • Low Noise Electronics
  • Inductive Sensors
  • Passive Electrical Devices

Curriculum Vitae

Matthias Gräser submitted his Dr.-Ing. thesis in january 2016 at the institute of medical engineering (IMT) at the university of Lübeck and is now working as a Research Scientist at the institute for biomedical imaging (IBI) at the technical university in Hamburg, Germany.  Here he develops concepts for Magnetic-Particle-Imaging (MPI) devices. His main aim is to improve the sensitivity of the imageing devices and improve resolution and application possibilities of MPI technology.

In 2011 Matthias Gräser started to work at the IMT as a Research Associate in the Magnetic Particle Imaging Technology (MAPIT) project. In this project he devolped the analog signal chains for a rabbit sized field free line imager. Additionally he developed a two-dimensional Magnetic-Particle-Spectrometer. This device can apply various field sequences and measure the particle response with a very high signal-to-noise ratio (SNR).

The dynamic behaviour of magnetic nanoparticles is still not fully understood. Matthias Gräser investigated the particle behaviour by modeling the particle behaviour with stochastic differential equations. With this model it is possible to simulate the impact of several particle parameters and field sequences on the particle response .

In 2010 Matthias Gräser finished his diploma at the Karlsruhe Institue of Technology (KIT). His diploma thesis investigated the nerve stimulation of magnetic fields in the range from 4 kHz to 25 kHz.

Journal Publications

[140972]
Title: Magnetic particle imaging for assessment of cerebral perfusion and ischemia.
Written by: P. Ludewig, M. Graeser, N. D. Forkert, F. Thieben, J. Rández-Garbayo, J. Rieckhoff, K. Lessmann, F. Foerger, P. Szwargulski, T. Magnus, and T. Knopp
in: <em>Wiley Interdiscip Rev Nanomed Nanobiotechnol</em>. (2022).
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DOI: 10.1002/wnan.1757
URL: https://pubmed.ncbi.nlm.nih.gov/34617413/
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[www] [BibTex]

Note: article, openaccess

Abstract: Stroke is one of the leading worldwide causes of death and sustained disability. Rapid and accurate assessment of cerebral perfusion is essential to diagnose and successfully treat stroke patients. Magnetic particle imaging (MPI) is a new technology with the potential to overcome some limitations of established imaging modalities. It is an innovative and radiation-free imaging technique with high sensitivity, specificity, and superior temporal resolution. MPI enables imaging and diagnosis of stroke and other neurological pathologies such as hemorrhage, tumors, and inflammatory processes. MPI scanners also offer the potential for targeted therapies of these diseases. Due to lower field requirements, MPI scanners can be designed as resistive magnets and employed as mobile devices for bedside imaging. With these advantages, MPI could accelerate and improve the diagnosis and treatment of neurological disorders. This review provides a basic introduction to MPI, discusses its current use for stroke imaging, and addresses future applications, including the potential for clinical implementation. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease.

Conference Proceedings

[140972]
Title: Magnetic particle imaging for assessment of cerebral perfusion and ischemia.
Written by: P. Ludewig, M. Graeser, N. D. Forkert, F. Thieben, J. Rández-Garbayo, J. Rieckhoff, K. Lessmann, F. Foerger, P. Szwargulski, T. Magnus, and T. Knopp
in: <em>Wiley Interdiscip Rev Nanomed Nanobiotechnol</em>. (2022).
Volume: Number:
on pages:
Chapter:
Editor:
Publisher:
Series:
Address:
Edition:
ISBN:
how published:
Organization:
School:
Institution:
Type:
DOI: 10.1002/wnan.1757
URL: https://pubmed.ncbi.nlm.nih.gov/34617413/
ARXIVID:
PMID:

[www] [BibTex]

Note: article, openaccess

Abstract: Stroke is one of the leading worldwide causes of death and sustained disability. Rapid and accurate assessment of cerebral perfusion is essential to diagnose and successfully treat stroke patients. Magnetic particle imaging (MPI) is a new technology with the potential to overcome some limitations of established imaging modalities. It is an innovative and radiation-free imaging technique with high sensitivity, specificity, and superior temporal resolution. MPI enables imaging and diagnosis of stroke and other neurological pathologies such as hemorrhage, tumors, and inflammatory processes. MPI scanners also offer the potential for targeted therapies of these diseases. Due to lower field requirements, MPI scanners can be designed as resistive magnets and employed as mobile devices for bedside imaging. With these advantages, MPI could accelerate and improve the diagnosis and treatment of neurological disorders. This review provides a basic introduction to MPI, discusses its current use for stroke imaging, and addresses future applications, including the potential for clinical implementation. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease.