Florian Thieben, M.Sc.

Universitätsklinikum Hamburg-Eppendorf (UKE)
Sektion für Biomedizinische Bildgebung
Lottestraße 55
2ter Stock, Raum 212
22529 Hamburg

Technische Universität Hamburg (TUHH)
Institut für Biomedizinische Bildgebung
Gebäude E, Raum 4.044
Am Schwarzenberg-Campus 3
21073 Hamburg

Tel.: 040 / 7410 25812
E-Mail: f.thieben(at)uke.de
E-Mail: florian.thieben(at)tuhh.de

Research Interests

  • Magnetic Particle Imaging
  • Low Noise Electronics
  • Inductive Sensors

Curriculum Vitae

Florian Thieben is a PhD student in the group of Tobias Knopp for experimental Biomedical Imaging at the University Medical Center Hamburg-Eppendorf and the Hamburg University of Technology. In 2017 he graduated with a master's degree thesis on Entwicklung eines kompakten Magnet Partikel Spektrometers mit gradiometrischer Empfangskette".

Journal Publications

[145080]
Title: Development of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapment into human erythrocytesDevelopment of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapm
Written by: A. Antonelli, P. Szwargulski, E. S. Scarpa, F. Thieben, C. Grüttner, G. Ambrosi, L. Guidi, P. Ludewig, T. Knopp and M. Magnani
in: Nanomedicine April 2020
Volume: 15 Number: 8
on pages: 739-753
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Publisher: Future Medicine Ltd
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DOI:
URL: https://doi.org/10.2217/nnm-2019-0449
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[www] [BibTex]

Note: article

Abstract: Aim: Magnetic particle imaging (MPI) is highly promising for biomedical applications, but optimal tracers for MPI, namely superparamagnetic iron oxide-based contrast agents, are still lacking. Materials & methods: The encapsulation of commercially available nanoparticles, specifically synomag®-D and perimag®, into human red blood cells (RBCs) was performed by a hypotonic dialysis and isotonic resealing procedure. The amounts of superparamagnetic iron oxide incorporated into RBCs were determined by Fe quantification using nuclear magnetic resonance and magnetic particle spectroscopy. Results: Perimag-COOH nanoparticles were identified as the best nanomaterial for encapsulation in RBCs. Perimag-COOH-loaded RBCs proved to be viable cells showing a good magnetic particle spectroscopy performance, while the magnetic signal of synomag-D-COOH-loaded RBCs dropped sharply. Conclusion: Perimag-COOH-loaded RBCs could be a potential tool for MPI diagnostic applications.

Conference Publications

[145080]
Title: Development of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapment into human erythrocytesDevelopment of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapm
Written by: A. Antonelli, P. Szwargulski, E. S. Scarpa, F. Thieben, C. Grüttner, G. Ambrosi, L. Guidi, P. Ludewig, T. Knopp and M. Magnani
in: Nanomedicine April 2020
Volume: 15 Number: 8
on pages: 739-753
Chapter:
Editor:
Publisher: Future Medicine Ltd
Series:
Address:
Edition:
ISBN:
how published:
Organization:
School:
Institution:
Type:
DOI:
URL: https://doi.org/10.2217/nnm-2019-0449
ARXIVID:
PMID:

[www] [BibTex]

Note: article

Abstract: Aim: Magnetic particle imaging (MPI) is highly promising for biomedical applications, but optimal tracers for MPI, namely superparamagnetic iron oxide-based contrast agents, are still lacking. Materials & methods: The encapsulation of commercially available nanoparticles, specifically synomag®-D and perimag®, into human red blood cells (RBCs) was performed by a hypotonic dialysis and isotonic resealing procedure. The amounts of superparamagnetic iron oxide incorporated into RBCs were determined by Fe quantification using nuclear magnetic resonance and magnetic particle spectroscopy. Results: Perimag-COOH nanoparticles were identified as the best nanomaterial for encapsulation in RBCs. Perimag-COOH-loaded RBCs proved to be viable cells showing a good magnetic particle spectroscopy performance, while the magnetic signal of synomag-D-COOH-loaded RBCs dropped sharply. Conclusion: Perimag-COOH-loaded RBCs could be a potential tool for MPI diagnostic applications.