Florian Thieben, M.Sc.

Universitätsklinikum Hamburg-Eppendorf (UKE)
Sektion für Biomedizinische Bildgebung
Lottestraße 55
2ter Stock, Raum 202
22529 Hamburg
- Postanschrift -

Technische Universität Hamburg (TUHH)
Institut für Biomedizinische Bildgebung
Gebäude E, Raum 4.044
Am Schwarzenberg-Campus 3
21073 Hamburg

Tel.: 040 / 7410 56355
E-Mail: f.thieben(at)uke.de
E-Mail: florian.thieben(at)tuhh.de
ORCID: https://orcid.org/0000-0002-2890-5288

Research Interests

  • Magnetic Particle Imaging
  • Low noise electronics
  • Inductive sensors and filters
  • Magnetic Particle Imaging scanner characterization

Curriculum Vitae

Florian Thieben is a PhD student in the group of Tobias Knopp for experimental Biomedical Imaging at the University Medical Center Hamburg-Eppendorf and the Hamburg University of Technology. In 2017 he graduated with a master's degree thesis on Entwicklung eines kompakten Magnet Partikel Spektrometers mit gradiometrischer Empfangskette".

Journal Publications

[145080]
Title: Optimization of magnetic nanoparticles for engineering erythrocytes as theranostic agents.
Written by: L. M. Slavu, A. Antonelli, E.S. Scarpa, P. Abdalla, C. Wilhelm, N. Silvestri, T. Pellegrino, K. Scheffler, M. Magnani, R. Rinaldi, R. Di Corato
in: <em>Biomater. Sci.</em>. March (2023).
Volume: Number:
on pages:
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Publisher: The Royal Society of Chemistry:
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DOI: 10.1039/D3BM00264K
URL: http://dx.doi.org/10.1039/D3BM00264K
ARXIVID:
PMID:

[www]

Note: article

Abstract: The application of superparamagnetic iron oxide nanoparticles (SPIONs) in drug delivery{,} magnetic resonance imaging{,} cell tracking{,} and hyperthermia has been long exploited regarding their inducible magnetic properties. Nevertheless{,} SPIONs remain rapidly cleared from the circulation by the reticuloendothelial system (RES) or mononuclear phagocyte system{,} with uptake dependent on several factors such as the hydrodynamic diameter{,} electrical charge and surface coating. This rapid clearance of SPION-based theranostic agents from circulation is one of the main challenges hampering the medical applications that differ from RES targeting. This work proposes a strategy to render biocompatible SPIONs through their encapsulation in the red blood cells (RBCs). In this work{,} the research has been focused on the multi-step optimization of chemical synthesis of magnetic nanoparticles (MNPs){,} precisely iron oxide nanoparticles (IONPs) and zinc manganese-ferrite nanoparticles (Zn/Mn FNPs){,} for encapsulation in human and murine RBCs. The encapsulation through the transient opening of RBC membrane pores requires extensive efforts to deliver high-quality nanoparticles in terms of chemical properties{,} morphology{,} stability and biocompatibility. After reaching this goal{,} in vitro experiments were performed with selected nanomaterials to investigate the potential of engineered MNP-RBC constructs in theranostic approaches.

Conference Proceedings

[145080]
Title: Optimization of magnetic nanoparticles for engineering erythrocytes as theranostic agents.
Written by: L. M. Slavu, A. Antonelli, E.S. Scarpa, P. Abdalla, C. Wilhelm, N. Silvestri, T. Pellegrino, K. Scheffler, M. Magnani, R. Rinaldi, R. Di Corato
in: <em>Biomater. Sci.</em>. March (2023).
Volume: Number:
on pages:
Chapter:
Editor:
Publisher: The Royal Society of Chemistry:
Series:
Address:
Edition:
ISBN:
how published:
Organization:
School:
Institution:
Type:
DOI: 10.1039/D3BM00264K
URL: http://dx.doi.org/10.1039/D3BM00264K
ARXIVID:
PMID:

[www] [BibTex]

Note: article

Abstract: The application of superparamagnetic iron oxide nanoparticles (SPIONs) in drug delivery{,} magnetic resonance imaging{,} cell tracking{,} and hyperthermia has been long exploited regarding their inducible magnetic properties. Nevertheless{,} SPIONs remain rapidly cleared from the circulation by the reticuloendothelial system (RES) or mononuclear phagocyte system{,} with uptake dependent on several factors such as the hydrodynamic diameter{,} electrical charge and surface coating. This rapid clearance of SPION-based theranostic agents from circulation is one of the main challenges hampering the medical applications that differ from RES targeting. This work proposes a strategy to render biocompatible SPIONs through their encapsulation in the red blood cells (RBCs). In this work{,} the research has been focused on the multi-step optimization of chemical synthesis of magnetic nanoparticles (MNPs){,} precisely iron oxide nanoparticles (IONPs) and zinc manganese-ferrite nanoparticles (Zn/Mn FNPs){,} for encapsulation in human and murine RBCs. The encapsulation through the transient opening of RBC membrane pores requires extensive efforts to deliver high-quality nanoparticles in terms of chemical properties{,} morphology{,} stability and biocompatibility. After reaching this goal{,} in vitro experiments were performed with selected nanomaterials to investigate the potential of engineered MNP-RBC constructs in theranostic approaches.