Dr.-Ing. Florian Griese

Technische Universität Hamburg (TUHH)
Institut für Biomedizinische Bildgebung
Gebäude E, Raum 4.044
Am Schwarzenberg-Campus 3
21073 Hamburg

E-Mail: florian.griese@tuhh.de

Research Interests

  • Magnetic Particle Imaging
  • Signal- and Image Processing
  • Image Registration
  • Parallel Force and Imaging MPI Application
  • Spectral-MPI for Interventional Application

Curriculum Vitae

Florian Griese studied Medical Engineering Science at the University of Lübeck between 2007 and 2012. He received his master's degree in medical engineering science from the University of Lübeck in 2012 on X-Space Reconstruction with Lissajous Trajectories in Magnetic Particle Imaging. Between 2013 and 2016 he worked as a software developer at EUROIMMUN in the field of automation development.
Currently, he is a PhD student in the group of Tobias Knopp for experimental Biomedical Imaging at the University Medical Center Hamburg-Eppendorf and the Hamburg University of Technology.

Publications

[134634]
Title: Simultaneous Magnetic Particle Imaging and Navigation of large superparamagnetic nanoparticles in bifurcation flow experiments.
Written by: F. Griese, T. Knopp, C. Gruettner, F. Thieben, K. Müller, S. Loges, P. Ludewig, N. Gdaniec
in: <em>Journal of Magnetism and Magnetic Materials</em>. 3 (2020).
Volume: <strong>498</strong>. Number:
on pages: 166206
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DOI: https://doi.org/10.1016/j.jmmm.2019.166206
URL: https://www.sciencedirect.com/science/article/pii/S0304885319320372?utm_campaign=STMJ_75273_AUTH_SERV_PPUB&utm_medium=email&utm_dgroup=Email1Publishing&utm_acid=208010593&SIS_ID=-1&dgcid=STMJ_75273_AUTH_SERV_PPUB&CMX_ID=&utm_in=DM620455&utm_source=AC_30&u
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Note: article

Abstract: Magnetic Particle Imaging (MPI) has been successfully used to visualize the distribution of superparamagnetic nanoparticles within 3D volumes with high sensitivity in real time. Since the magnetic field topology of MPI scanners is well suited for applying magnetic forces on particles and micron-sized ferromagnetic devices, MPI has been recently used to navigate micron-sized particles and micron-sized swimmers. In this work, we analyze the magnetophoretic mobility and the imaging performance of two different particle types for Magnetic Particle Imaging/Navigation (MPIN). MPIN constantly switches between imaging and magnetic modes, enabling quasi-simultaneous navigation and imaging of particles. We determine the limiting flow velocity to be 8.18 mL/s using a flow bifurcation experiment, that allows all particles to flow only through one branch of the bifurcation. Furthermore, we have succeeded in navigating the particles through the branch of a bifurcation phantom narrowed by either 60% or 100% stenosis, while imaging their accumulation on the stenosis. The particles in combination with therapeutic substances have a high potential for targeted drug delivery and could help to reduce the dose and improve the efficacy of the drug, e.g. for specific tumor therapy and ischemic stroke therapy.