Forschungsbericht 2020
Bioprozess- und Biosystemtechnik V-1
Leitung: Prof. Dr. An-Ping Zeng
Institut auf TORE
Institutswebsite
Publikationen
- Introduction of glycine synthase enables uptake of exogenous formate and strongly impacts the metabolism in Clostridium pasteurianum - Article
Hong, Yaeseong; Arbter, Philipp; Wang, Wei; Rojas, Lilian N.; Zeng, An-Ping
Biotechnology and Bioengineering 118 (3): 1366-1380 (2020)
Open Access Publisher DOI
- Metabolomic and kinetic investigations on the electricity-aided production of butanol by Clostridium pasteurianum strains - Article
Arbter, Philipp; Sabra, Wael; Utesch, Tyll; Hong, Yaeseong; Zeng, An-Ping
Engineering in Life Sciences 21 (3-4): 181-195 (2020)
Open Access Publisher DOI
- Structure-based dynamic analysis of the glycine cleavage system suggests key residues for control of a key reaction step - Article
Zhang, Han; Li, Yuchen; Nie, Jinglei; Ren, Jie; Zeng, An-Ping
Communications Biology 1 (3): 756 (2020-12)
Publisher DOI
- NMPC-based workflow for simultaneous process and model development applied to a fed-batch process for recombinant C. glutamicum - Article
Levermann, Philipp; Freiberger, Fabian; Katha, Uma; Zaun, Henning; Möller, Johannes; Hass, Volker C.; Schoop, Karl Michael; Kuballa, Jürgen; Pörtner, Ralf
Processes 8 (10): 1313 (2020-10-19)
Open Access Publisher DOI
- Regulation of pyruvate dehydrogenase complex related to lactate switch in CHO cells - Article
Möller, Johannes; Bhat, Krathika; Guhl, Lotta; Pörtner, Ralf; Jandt, Uwe; Zeng, An-Ping
Engineering in Life Sciences 21 (3-4): 100-114 (2020)
Open Access Publisher DOI
- Quantitative analysis of glycine related metabolic pathways for one-carbon synthetic biology - Article
Hong, Yaeseong; Ren, Jie; Zhang, Xinyi; Wang, Wei; Zeng, An-Ping
Current Opinion in Biotechnology (64): 70-78 (2020-08)
Publisher DOI
- Towards recombinantly produced milk proteins: Physicochemical and emulsifying properties of engineered whey protein beta-lactoglobulin variants - Article
Keppler, Julia; Heyse, Anja; Scheidler, Eva; Uttinger, Maximilian J.; Fitzner, Laura; Jandt, Uwe; Heyn, Timon R.; Lautenbach, Vanessa; Loch, Joanna; Lohr, Jonas; Kieserling, Helena; Günther, Gabriele; Kempf, Elena; Grosch, Jan Hendrik; Lewiński, Krzysztof; Jahn, Dieter; Lübbert, Christian; Peukert, Wolfgang; Kulozik, Ulrich; Drusch, Stephan; Krull, Rainer; Schwarz, Karin; Biedendieck, Rebekka
Food Hydrocolloids (110): 106132 (2021-01)
Open Access Publisher DOI
- Formaldehyde formation in the glycine cleavage system and its use for an aldolase-based biosynthesis of 1,3-prodanediol - Article
Xu, Yingying; Meng, Hao; Ren, Jie; Zeng, An-Ping
Journal of Biological Engineering 1 (14): 15 (2020-05-14)
Open Access Publisher DOI
- Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes - Article
Möller, Johannes; Hernández Rodríguez, Tanja; Müller, Jan; Arndt, Lukas; Kuchemüller, Kim Beatrice; Frahm, Björn; Eibl, Regine; Eibl, Dieter; Pörtner, Ralf
Computers and Chemical Engineering (134): 106693 (2020-03-04)
Open Access Publisher DOI
- Quantification of the dynamics of population heterogeneities in CHO cultures with stably integrated fluorescent markers - Article
Möller, Johannes; Rosenberg, Marcel; Riecken, Kristoffer; Pörtner, Ralf; Zeng, An-Ping; Jandt, Uwe
Analytical and Bioanalytical Chemistry 9 (412): 2065-2080 (2020-04-01)
Open Access Publisher DOI
- Co-cultures with integrated in situ product removal for lactate-based propionic acid production - Article
Selder, Ludwig; Sabra, Wael; Jürgensen, Nikolai; Lakshmanan, Alagappan; Zeng, An-Ping
Bioprocess and Biosystems Engineering 6 (43): 1027-1035 (2020-06-01)
Open Access Publisher DOI
- Measurement of length distribution of beta-lactoglobulin fibrils by multiwavelength analytical ultracentrifugation - Article
Uttinger, Maximilian J.; Heyn, Timon R.; Jandt, Uwe; Wawra, Simon E.; Winzer, Bettina; Keppler, Julia K.; Peukert, Wolfgang
European Biophysics Journal 8 (49): 745-760 (2020)
Open Access Publisher DOI
- Control of biosynthesis in bioelectrochemical systems - Article
Arbter, Philipp; Beisch, Hubert; Utesch, Tyll; Fiedler, Bodo; Zeng, An-Ping
Chemie Ingenieur Technik 9 (92): 1212-1212 (2020)
Publisher DOI
- Engineering of phosphoserine aminotransferase and new metabolic pathways for microbial production of 1,3-propanediol and 1,2,4-butanetriol from sugar - Thesis
Zhang, Yujun
Dr. Hut (2020)
Open Access
- Activation and competition of lipoylation of H protein and its hydrolysis in a reaction cascade catalyzed by the multifunctional enzyme lipoate–protein ligase A - Article
Zhang, Xinyi; Nie, Jinglei; Zheng, Yuanmin; Ren, Jie; Zeng, An-Ping
Biotechnology and Bioengineering (in Press): (2020)
Publisher DOI
- Estimation of process model parameters - inBook
Deppe, Sahar; Frahm, Björn; Hass, Volker C.; Hernández Rodríguez, Tanja; Kuchemüller, Kim Beatrice; Möller, Johannes; Pörtner, Ralf
Methods in Molecular Biology (2095): 213-234 (2020)
Publisher DOI
- Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation: applied to an industrial cell culture seed train - Article
Hernández Rodríguez, Tanja; Posch, Christoph; Pörtner, Ralf; Frahm, Björn
Bioprocess and Biosystems Engineering (in Press): (2020)
Publisher DOI
- Novel approaches for in vivo evolution, screening and characterization of enzymes for metabolic engineering of Escherichia coli as hyper L-tryptophan producer - Thesis
Minliang, Chen
Dr. Hut (2020)
Open Access
- Modeling and experimental analysis of antibody-producing cell culture processes : from metabolism over population to design and scale-up - Thesis
Möller, Johannes
Dr. Hut 978-3-8439-4591-2: (2020)
- Open Access for the future - editorial
Zeng, An-Ping; Bley, Thomas; Takors, Ralf; Flemming, Danielle
Engineering in Life Sciences 1-2 (20): 4 (2020)
Publisher DOI
- Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes - Poster
Hernández Rodríguez, Tanja; Posch, Christoph; Pörtner, Ralf; Frahm, Björn
Chemie Ingenieur Technik 9 (92): 1241-1242 (2020)
Publisher DOI
- Efficient optimization of process strategies with model-assisted design of experiments - inBook
Kuchemüller, Kim Beatrice; Pörtner, Ralf; Möller, Johannes
Methods in Molecular Biology (2095): 235-249 (2020)
Publisher DOI
- Near-physiological cell cycle synchronization with countercurrent centrifugal elutriation - inBook
Möller, Johannes; Korte, Katrin; Pörtner, Ralf; Zeng, An-Ping; Jandt, Uwe
Methods in Molecular Biology (2095): 3-16 (2020)
Publisher DOI
- Data‐driven multiscale modeling of self‐assembly and hierarchical structural formation in biological macromolecular systems - Poster
Depta, Andreas; Jandt, Uwe; Jacobi, Cornelius; Dosta, Maksym; Zeng, An-Ping; Heinrich, Stefan
Chemie Ingenieur Technik 92 (9): 1249-1249 (2020)
Publisher DOI
Projekte
- BIBER - Dynamische Modellierung und Gesamtevaluation des Systems
Bundesministerium für Ernährung und Landwirtschaft; Laufzeit 2020 - 2023
Projektleitung: Zeng, An-Ping
- EnzymProzess - UfIB: Neue Technologien zur Entwicklung von Prozessführungsstrategien für enzymatische Prozesse unter hohem Druck-EnzymProzess
Bundesministerium für Bildung und Forschung; Laufzeit 2019 - 2022
Projektleitung: Pörtner, Ralf
Mitarbeitende: Arndt, Lukas
- TI-Bioraffinerien: ELBE-NH-Effektivitätssteigerung von Lignin Bioraffinerien durch ergänzende Nutzung von Hydrolysaten (Teilprojekt E)
Bundesministerium für Bildung und Forschung; Laufzeit 2019 - 2021
Projektleitung: Zeng, An-Ping
Mitarbeitende: Sabra, Wael; Selder, Ludwig
- SPP 2170: Teilprojekt "CaproMix - Entwicklung neuer und definierter Co-Kulturen zur Bioproduktion von Capronsäure aus Kohlendioxid"
Deutsche Forschungsgemeinschaft (DFG); Laufzeit 2019 - 2022
Projektleitung: Zeng, An-Ping
Mitarbeitende: Herzog, Jan
- mDoE-Toolbox 2 - IBÖM04:mDoE-Toolbox2-Neue mDoE Software-Toolbox zur modellgestützten Optimierung biotechnologischer Prozesse
Bundesministerium für Bildung und Forschung; Laufzeit 2018 - 2020
Projektleitung: Pörtner, Ralf
Mitarbeitende: Möller, Johannes; Kuchemüller, Kim Beatrice; Freiberger, Fabian
- protP.S.I. C2 - Modulation der Reaktivität von Proteinen durch Druck (prot P.S.I.) - TP C2: Neue Technologien zur Entwicklung von Prozessführungsstrategien
Bundesministerium für Bildung und Forschung; Laufzeit 2018 - 2021
Projektleitung: Pörtner, Ralf
Mitarbeitende: Levermann, Philipp; Arndt, Lukas
- EnzymAgglo - Teilprojekt von SPP 1934: Multiskalige modellgestützte Untersuchungen funktionaler Enzym- und Proteinagglomerate für biotechnologische Anwendung - Teil 2: Von der Struktur zur Funktion
Deutsche Forschungsgemeinschaft (DFG); Laufzeit 2016 - 2022
Projektleitung: Heinrich, Stefan; Zeng, An-Ping
- SpeCCC - Specialised Cell Carrier Components
European Union; Laufzeit 2012 - 2021
Projektleitung: Pörtner, Ralf
Mitarbeitende: Schaffer, Christiane; Arndt, Lukas
- General methods and tools for systems and synthetic biology
Technische Universität Hamburg; Laufzeit 2007 - 2021
Projektleitung: Zeng, An-Ping
Mitarbeitende: Jandt, Uwe
- Bioprocess and Biosystems Engineering - Microbial and enzymatic Systems
Technische Universität Hamburg; Laufzeit 2006 - 2030
Projektleitung: Zeng, An-Ping
Mitarbeitende: Arbter, Philipp; Chen, Lin
- Bioprocess and Biosystems Engineering - Mammalian Cell Cultures
Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft (DFG); Technische Universität Hamburg; Laufzeit 2006 - 2030
Projektleitung: Zeng, An-Ping
Mitarbeitende: Pörtner, Ralf; Jandt, Uwe
Kooperationspartner
- Prof. U. Fritsching, University of Bremen
- Prof. Yue Feng, Beijing University of Chemical Technology
- Prof. Dr.-Ing. Udo Reichl, MPI Magdeburg
- Infors AG, Schweiz
- Dr. J. Keppler, Christian-Albrechts-University Kiel
- Evonik Nutrition & Care GmbH
- Landwirtschaftliche Universität Athen (DFST-AUA),Abt. für Lebensmittel und Technologie, Greece
- Prof. Dr.-Ing. Dieter Eibl, ZHAW Wädenswil, Schweiz
- Ingenieurbüro Dr.-Ing. Schoop GmbH
- Prof. Dr.-Ing. Thomas Becker, TU München
- Dr. Jingxiu Bi, Aldelaide University, Australien
- Prof. K. Schwarz, Christian-Albrechts-University Kiel
- Universidade de Santiago de Compostela, Spanien
- Haldor Topsoe, Denmark
- Centre National de la recherche scientifique, France
- CNRS
- Prof. Dr. Udo Schumacher, UKE Hamburg
- Dr. Uwe Marx, TissUse GmbH, Berlin
- ZellWerk GmbH, Eichstädt
- Cell and Gene Therapy, Clinic for Stem Cell Transplantation, University Medical Centre (UMC) Hamburg-Eppendorf, Hamburg, K. Riecken
- Prof. Dr. Georg Conrads, RWTH Aachen
- Prof. Zhen Chen, Tsinghua University, China
- Danish Technological Institute, Denmark
- Prof. Dr. Zhi-Long Xiu, Dalian University of Technology, China
- Prof. Dr.-Ing. Peter Czermak, TH Mittelhessen, Gießen
- Prof. Dr. Michael Amling, UKE Hamburg
- Prof. Dr. Rolf Müller, Helmholtz Institute of Pharmaceutical Research, Saarbrücken
- Technische Hochschule Aachen, Germany
- Bioengineering AG, Wald, Schweiz
- Prof. Jingqi Yuan, Jiaotong University, Shanghai, China
- Nykomb, Sweden
- European Biomass Industry Association, Belgium
- Prof. Dr. Roland Lauster, TU Berlin
- Helmholzzentrum für Infektionsforschung (HZI), Braunschweig
- Prof. Dr. Christian Apel, RWTH Aachen
- Karlsruher Institut für Technologie (KIT)
- Prof. Dr. Thomas Noll, Uni Bielefeld
- ProBioGen AG, Berlin
- Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Beijing
- Dr. H. Ma, University Edinburgh, UK and Chinese Academy of Sciences
- Dr. Azad Emin, KIT, Karlsruhe
- HF Biotec Berlin GmbH
- Quantis, Switzerland
- Prof. Dr.-Ing. Hoc Kiem Trieu, Technische Universität Hamburg-Harburg, Institut für Mikrosystemtechnik
- Sintef, Norway
- Prof. Dr. Thomas Scheper, Universität Hannover
- Bioglobe GmbH, Hamburg
- VTT Technical Research Centre of Finland Ltd.
- VOCO GmbH, Dr. Maletz, Dr. Berg, Cuxhaven
- Prof. Dr. Stefan Schulz, TU Braunschweig
- Arkema, France
- OrganoBalance GmbH, Berlin
- DTL Biotechnology Ltd, Ireland
- Fraunhofer Einrichtung Marine Biotechnologie, Lübeck
- Prof. Ying-jin Yuan, Tianjin University, China
- medorex eK, Bovenden
- Prof. Dr.-Ing. Volker C. Hass, HS Furtwangen
- Prof. Dr. Irene Wagner-Döbler, Helmholtz-Zentrum für Infektionsforschung, Braunschweig
- Prof. H. Karbstein, Karlsruhe Institut of Technology
- Dr.-Ing. Gerd Huber, TU Hamburg
- DESY Hamburg, EMBL (Biostruct X, R. Meijers)
- Prof. Dr. Andreas Kremling, TU München
- Prof. Dr. Elmar Heinzle, Uni Saarbrücken
- GALAB GmbH, Hamburg
- Agricultural University of Athens, Greece
- FRIAS (Freiburg Institute for Advanced Studies), group S.Schiller
- Umicore, Belgium
- Prof. Dr.-Ing. Björn Frahm, FH Lemgo