Bioprocess and Biosystems Engineering - Mammalian Cell Cultures

Fundamentals and process development of cell cultures for application in pharmaceutical industry

Stichworte

• Biochemical Engineering
• Bioprozesstechnik
• Biosystems Engineering
• Biotechnologie
• Cell culture
• Cell cycle

Publikationen

• Uwe Jandt, Oscar Platas Barradas, Ralf Pörtner and An-Ping Zeng: Synchronized mammalian cell culture: Part II Population ensemble modeling and analysis for development of reproducible processes. . Biotechnol. Proress., 2014 (accepted), (accepted) 2014.
• Rajabi, Negar and Hoffmann, Marko and Bahnemann, Janina and Zeng, An-Ping and Schlüter, Michael and Müller, Jörg: A Chaotic Advection Enhanced Microfluidic Split-and-Recombine Mixer for the Preparation of Chemical and Biological Probes. JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, 45: S. 703--707, 2012. , DOI: 10.1252/jcej.12we071, http://japanlinkcenter.org/DN/JST.JSTAGE/jcej/12we071?lang=en&from=CrossRef&type=abstract
• Bahnemann, J and Rajabi, N and Fuge, G and Barradas, O P and Müller, J and Pörtner, R and Zeng, A P: A New Integrated Lab-on-a-Chip System for Fast Dynamic Study of Mammalian Cells under Physiological Conditions in Bioreactor. Cells, 2(2): S. 349--360, 2013. , DOI: 10.3390/cells2020349
• Liu, Yuan-Hua and Bi, Jing-Xiu and Zeng, An-Ping and Yuan, Jing-Qi: A cybernetic model to describe the dynamics of myeloma cell cultivations. Applied Mathematics and Computation, 205(1): S. 84--97, 2008. , DOI: 10.1016/j.amc.2008.05.066
• Zhou, Feng and Bi, Jing-Xiu and Zeng, An-Ping and Yuan, Jing-Qi: A macrokinetic and regulator model for myeloma cell culture based on metabolic balance of pathways. Process Biochemistry, 41(10): S. 2207--2217, oct 2006. , DOI: 10.1016/j.procbio.2006.08.001, http://linkinghub.elsevier.com/retrieve/pii/S1359511306003205
• Zhou, F and Bi, J and Zeng, A P and Yuan, J: A macrokinetic model for myeloma cell culture based on stoichiometric balance. Biotechnol Appl Biochem, 46(Pt 2): S. 85--95, 2007. , DOI: 10.1042/BA20060021
• Kayo, S and Bahnemann, J and Klauser, M and Portner, R and Zeng, A P: A microfluidic device for immuno-affinity-based separation of mitochondria from cell culture. Lab Chip, 13(22): S. 4467-4475, 2013. , DOI: 10.1039/c3lc50739d
• Liu, Y H and Bi, J X and Zeng, A P and Yuan, J Q: A population balance model describing the cell cycle dynamics of myeloma cell cultivation. Biotechnol Prog, 23(5): S. 1198--1209, 2007. , DOI: 10.1021/bp070152z
• Liu, Y H and Bi, J X and Zeng, A P and Yuan, J Q: A simple kinetic model for myeloma cell culture with consideration of lysine limitation. Bioprocess Biosyst Eng, 31(6): S. 569--577, 2008. , DOI: 10.1007/s00449-008-0204-x
• Platas, Oscar B and Jandt, Uwe and Sandig, Volker and Pörtner, Ralf and Zeng, An-Ping: An integrated synchronization approach for studying cell-cycle dependent processes of mammalian cells under physiological conditions. BMC Proceedings, 7(Suppl 6): S. P16, 2013. , DOI: 10.1186/1753-6561-7-S6-P16
• Freund, Susann and Rath, Alexander and Barradas, Oscar Platas and Skerhutt, Eva and Scholz, Sebastian and Niklas, Jens and Sandig, Volker and Rose, Thomas and Heinzle, Elmar and Noll, Thomas and Pörtner, Ralf and Zeng, An Ping and Reichl, Udo: Batch-to-batch variability of two human designer cell lines: AGE1.HN and AGE1.HN.AAT ; carried out by different laboratories under defined culture conditions using a mathematical model. Engineering in Life Sciences, 13(6): S. 580–592, Juni 2013. , DOI: 10.1002/elsc.201200111, http://dx.doi.org/10.1002/elsc.201200111
• Meyne, Nora and Fuge, Grischa and Hemanth, Suhith and Trieu, Hoc Khiem and Zeng, An-Ping and Jacob, Arne F.: Broadband dielectric characterization of CHO-K1 cells using miniaturized transmission-line sensor. In 2015 IEEE Topical Conference on Biomedical Wireless Technologies, Networks, and Sensing Systems (BioWireleSS), S. 1--3, jan 2015., DOI: 10.1109/BIOWIRELESS.2015.7152127, http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=7152127
• Grischa Fuge, Yaeseong Hong, Kristoffer Riecken, An-Ping Zeng, Uwe Jandt: CHO cells engineered for fluorescence read out of cell cycle and growth rate in real time. Biotechnology Progress(33): S. 1408-1417, 2017.
• Schrader, E and Scholz, S and Niklas, J and Rath, A and Barradas, O P and Jandt, U and Sandig, V and Rose, T and Portner, R and Reichl, U and Zeng, A P and Heinzle, E and Noll, T: Characterisation of cultivation of the human cell line AGE1.HN.AAT. BMC Proc, 5 Suppl 8: S. P87, 2011. , DOI: 10.1186/1753-6561-5-S8-P87
• Zeng, An-Ping: Editorial: From Biochemical Engineering to Systems Biology. Process Biochemistry, 41(10): S. 2101--2102, oct 2006. , DOI: 10.1016/j.procbio.2006.07.037, http://linkinghub.elsevier.com/retrieve/pii/S1359511306003321
• Castillo Salvador, Alan Eduardo and Fuge, Grischa and Jandt, Uwe and Zeng, An-Ping: Growth kinetics and validation of near-physiologically synchronized HEK293S Cultures. Engineering in Life Sciences, 15(5): S. 509--518, jul 2015. , DOI: 10.1002/elsc.201400224, http://doi.wiley.com/10.1002/elsc.201400224
• Rajabi, Negar and Bahnemann, Janina and Tzeng, Tzu-Nen and Platas Barradas, Oscar and Zeng, An-Ping and Müller, Jörg: Lab-on-a-chip for cell perturbation, lysis, and efficient separation of sub-cellular components in a continuous flow mode. Sensors and Actuators A: Physical, 215: S. 136--143, aug 2014. , DOI: 10.1016/j.sna.2013.12.019, http://linkinghub.elsevier.com/retrieve/pii/S0924424713006109
• Jandt, U and Platas Barradas, O and Portner, R and Zeng, A P: Mammalian cell culture synchronization under physiological conditions and population dynamic simulation. Appl Microbiol Biotechnol, 98(10): S. 4311-4319, 2014. , DOI: 10.1007/s00253-014-5553-6
• Wurm, M and Zeng, A P: Mechanical disruption of mammalian cells in a microfluidic system and its numerical analysis based on computational fluid dynamics. Lab Chip, 12(6): S. 1071--1077, 2012. , DOI: 10.1039/c2lc20918g
• He, F and Chen, H and Probst-Kepper, M and Geffers, R and Eifes, S and Del Sol, A and Schughart, K and Zeng, A P and Balling, R: PLAU inferred from a correlation network is critical for suppressor function of regulatory T cells. Mol Syst Biol, 8: S. 624, 2012. , DOI: 10.1038/msb.2012.56