Bioprocess and Biosystems Engineering - Microbial and enzymatic Systems

Development of general methods and tools of bioprocess and biosystems engineering and their applications for bioprocess development in industrial and pharmaceutical biotechnologies.

Stichworte

• Biogas
• Biokatalyse
• Biokonversion
• Bioprozesstechnik
• Bioraffinerie
• Bioreaktor
• Biosystems Engineering
• Biotechnologie
• Fermentationstechnik

Publikationen

• Uwe Jandt, Oscar Platas Barradas, Ralf Pörtner and An-Ping Zeng: Synchronized mammalian cell culture: Part II Population ensemble modeling and analysis for development of reproducible processes. . Biotechnol. Proress., 2014 (accepted), (accepted) 2014.
• T. Kaeding, D. Tjahjasari and A.-P. Zeng: 1,3-Propanediol and Polytrimethyleneterephthalate. Elsevier, , 2011
• Liu, Yuan-Hua and Bi, Jing-Xiu and Zeng, An-Ping and Yuan, Jing-Qi: A cybernetic model to describe the dynamics of myeloma cell cultivations. Applied Mathematics and Computation, 205(1): S. 84--97, 2008. , DOI: 10.1016/j.amc.2008.05.066
• Chen, L and Zeng, A and Dong, H and Li, Q and Niu, C: A novel process for recovery and refining of L-lactic acid from fermentation broth. Bioresour Technol, 112: S. 280--284, 2012. , DOI: 10.1016/j.biortech.2012.02.100
• Liu, Y H and Bi, J X and Zeng, A P and Yuan, J Q: A population balance model describing the cell cycle dynamics of myeloma cell cultivation. Biotechnol Prog, 23(5): S. 1198--1209, 2007. , DOI: 10.1021/bp070152z
• : Alginates: Biology and Applications. Springer Berlin Heidelberg, , 2009
• da Luz, Julian A., Hans, Enrico, Frank, Doinita, Zeng, An-Ping: Analysis of intracellular metabolites of Corynebacterium glutamicum at high cell density with automated sampling and filtration and assessment of engineered enzymes for effective L-lysine production. Engineering in Life Sciences, 17: S. 512-522, 2017. , DOI: 10.1002/elsc.201600163
• Sabra, Wael; Dietz, David; Tjahjasari, Donna; Zeng, An-Ping : Biosystems analysis and engineering of microbial consortia for industrial biotechnology. Engineering in Life Sciences(10): S. 407-421, 2010.
• Dietz, D and Sabra, W and Zeng, A P: Co-cultivation of Lactobacillus zeae and Veillonella cricetifor the production of propionic acid. AMB Express, 3(1): S. 29, 2013. , DOI: 10.1186/2191-0855-3-29
• Seraphim Papanikolaou, Maria Rontou, Aikaterini Belka, Maria Athenaki, Chryssavgi Gardeli, Athanasios Mallouchos, Ourania Kalantzi, Apostolis A. Koutinas, An-Ping Zeng, George Aggelis: Conversion of biodiesel-derived glycerol into biotechnological products of industrial significance by a relatively broad spectrum of yeasts and fungi. Eng. Life Sci., 17(3): S. 262-281, 2017. , DOI: 10.1002/elsc.201500191
• Chen, Z and Bommareddy, R R and Frank, D and Rappert, S and Zeng, A P: Deregulation of feedback inhibition of phosphoenolpyruvate carboxylase for improved lysine production in Corynebacterium glutamicum. Appl Environ Microbiol, 80(4): S. 1388--1393, 2014. , DOI: 10.1128/AEM.03535-13
• Bley, Thomas and Zeng, An-Ping: Editorial: Biomaterials Made in Bioreactors. Engineering in Life Sciences, 15(7): S. 669--669, oct 2015. , DOI: 10.1002/elsc.201570073, http://doi.wiley.com/10.1002/elsc.201570073
• Chatzifragkou, A and Dietz, D and Komaitis, M and Zeng, A P and Papanikolaou, S: Effect of biodiesel-derived waste glycerol impurities on biomass and 1,3-propanediol production of Clostridium butyricum VPI 1718. Biotechnol Bioeng, 107(1): S. 76--84, 2010. , DOI: 10.1002/bit.22767
• Dietz, D and Zeng, A P: Efficient production of 1,3-propanediol from fermentation of crude glycerol with mixed cultures in a simple medium. Bioprocess Biosyst Eng, 37(2): S. 225--233, 2014. , DOI: 10.1007/s00449-013-0989-0
• Lifu Song and An-Ping Zeng: Engineering cells as robots for parallel and highly sensitive screening of biomolecules under in vivo conditions. Sci. Report, 7(15145), 2017.
• Metsoviti, M and Zeng, A P and Koutinas, A A and Papanikolaou, S: Enhanced 1,3-propanediol production by a newly isolated Citrobacter freundii strain cultivated on biodiesel-derived waste glycerol through sterile and non-sterile bioprocesses. J Biotechnol, 163(4): S. 408--418, 2013. , DOI: 10.1016/j.jbiotec.2012.11.018
• Zhen Chen, Feng Geng, and An-Ping Zeng : Erratum: Protein design and engineering of a de novo pathway for microbial production of 1, 3-propanediol from glucose. Biotechnology Journal(1368-1368), 2016.
• Geng, F and Chen, Z and Zheng, P and Sun, J and Zeng, A P: Exploring the allosteric mechanism of dihydrodipicolinate synthase by reverse engineering of the allosteric inhibitor binding sites and its application for lysine production. Appl Microbiol Biotechnol, 97(5): S. 1963--1971, 2013. , DOI: 10.1007/s00253-012-4062-8
• Sabra W, Wang W, Surandram S, Groeger C, Zeng A-P: Fermentation of mixed substrates by Clostridium pasteurianum and its physiological, metabolic and proteomic characterizations. Microb Cell Fact (15): S. 114, 2016.
• Lei Qin, Lu Liu, An-Ping Zeng, Dong Wei: From low-cost substrates to microbial lipid by oleaginous yeast and microalgae as cell factory. Bioresources Technology, 245: S. 1507-1519, 2017.
• Zheng, P and Sun, J and Geffers, R and Zeng, A P: Functional characterization of the gene PA2384 in large-scale gene regulation in response to iron starvation in Pseudomonas aeruginosa. J Biotechnol, 132(4): S. 342--352, 2007. , DOI: 10.1016/j.jbiotec.2007.08.013
• Zeng, An-Ping: Fundamentals and Application of New Bioproduction Systems. Springer, , 2013
• Rajesh Reddy Bommareddy, Wael Sabra and An-Ping Zeng : Glucose‐mediated regulation of glycerol uptake in Rhodosporidium toruloides: Insights through transcriptomic analysis on dual substrate fermentation. Eng. Life Sciences, 17(3): S. 282-291, 2017. , DOI: 10.1002/elsc.201600010
• Zeng, An-Ping and Kaltschmitt, Martin: Green electricity and biowastes via biogas to bulk-chemicals and fuels: The next move toward a sustainable bioeconomy. Engineering in Life Sciences, 16: S. 211-221, 2016. , DOI: 10.1002/elsc.201400262, http://doi.wiley.com/10.1002/elsc.201400262
• Chatzifragkou, A and Aggelis, G and Komaitis, M and Zeng, A P and Papanikolaou, S: Impact of anaerobiosis strategy and bioreactor geometry on the biochemical response of Clostridium butyricum VPI 1718 during 1,3-propanediol fermentation. Bioresour Technol, 102(22): S. 10625--10632, 2011. , DOI: 10.1016/j.biortech.2011.09.023
• Sabra, W and Groeger, C and Sharma, P N and Zeng, A P: Improved n-butanol production by a non-acetone producing Clostridium pasteurianum DSMZ 525 in mixed substrate fermentation. Appl Microbiol Biotechnol, 98(9): S. 4267--4276, 2014. , DOI: 10.1007/s00253-014-5588-8
• Julian A. da Luz, Enrico Hans and An-Ping Zeng : Improvement of intracellular metabolite analysis of microorganisms by automated fast filtration and on-filter quenching. Eng. Life Sciences: S. 135-142, 2014.
• Julian A. da Luz, Enrico Hans and An-Ping Zeng: Improvement of intracellular metabolite analysis of microorganisms by automated fast filtration and on-filter quenching. Engineering in Life Sciences(14): S. 135-142, 2014.
• Gu, MB and Zeng, An-Ping: Industrial biotechnology in Asia - recent advances in biofuels and biorefinery. Engineering in Life Sciences, 13(5): S. 419--420, sep 2013. , DOI: 10.1002/elsc.201370054, http://doi.wiley.com/10.1002/elsc.201370054
• Kaeding, Thomas and DaLuz, Julian and Kube, Jürgen and Zeng, An-Ping: Integrated study of fermentation and downstream processing in a miniplant significantly improved the microbial 1,3-propanediol production from raw glycerol. Bioprocess and Biosystems Engineering, 38(3): S. 575--586, mar 2015. , DOI: 10.1007/s00449-014-1297-z, http://link.springer.com/10.1007/s00449-014-1297-z
• Gröger, C and Sabra, W and Zeng, A-P: Introduction to Bioconversion and Downstream Processing: Principles and Process Examples. In Aresta, M., Hrsg., Biorefineries , S. 81--104. De Gruyter Graduate, 2015.
• Li, J and Wang, W and Ma, Y and Zeng, A P: Medium optimization and proteome analysis of (R,R)-2,3-butanediol production by Paenibacillus polymyxa ATCC 12321. Appl Microbiol Biotechnol, 97(2): S. 585--597, 2013. , DOI: 10.1007/s00253-012-4331-6
• Christin Groeger, Wei Wang, Wael Sabra, Tyll Utesch and An-Ping Zeng: Metabolic and proteomic analyses of product selectivity and redox regulation in Clostridium pasteurianum grown on glycerol under varied iron availability. Microb. Cell Fact., 16(1): S. 64, 2017.
• Sabra, W. and Groeger, C. and Zeng, An-Ping: Microbial Cell Factories for Diol Production. In , Hrsg., Advances in Biochemical Engineering/Biotechnology . Springer, 2016. , DOI: 10.1007/10\_2015\_330, http://link.springer.com/10.1007/10\_2015\_330
• Ulmer, C. and Zeng, A.P.: Microbial Production of 3-hydroxypropionaldehyde from Glycerol Bioconversion. Chemical & Biochemical Engineering Quarterly, 21(4): S. 321--326, dec 2007. , http://hrcak.srce.hr/index.php?show=clanak&id\_clanak\_jezik=28609&lang=en
• Sabra, Wael and Zeng, An Ping: Microbial Production of Alginates: Physiology and Process Aspects. In Rehm, Bernd H. A., Hrsg., Alginates: Biology and Applications , Jg. 13 von Microbiology Monographs, S. 153--173. Springer Berlin Heidelberg, 2009. , DOI: 10.1007/978-3-540-92679-5\_7
• Röske, Immo; Sabra, Wael; Nacke, Keiko; Daniel, Rolf; Zeng, An-Ping; Antranikian, Garabed; Sahm, Kerstin : Microbial community composition and dynamics in high-temperature biogas reactors using industrial bioethanol waste as substrate. Appl. Microbial and Biotechnol. , 2014(98): S. 9095-9106, 2014.
• Wael Sabra, Jian-Ying Dai, Hendrich Quitmann, A.-P. Zeng and Zhi-Long Xiu: Microbial production of 2, 3-butanediol. . Elsevier , , 2011
• Zeng, A P and Sabra, W: Microbial production of diols as platform chemicals: recent progresses. Curr Opin Biotechnol, 22(6): S. 749--757, 2011. , DOI: 10.1016/j.copbio.2011.05.005
• Wurm, M and Schopke, B and Lutz, D and Muller, J and Zeng, A P: Microtechnology meets systems biology: the small molecules of metabolome as next big targets. J Biotechnol, 149(1-2): S. 33--51, 2010. , DOI: 10.1016/j.jbiotec.2010.05.002
• Zeng, A P: New biotechnological production systems. Biotechnol J, 6(8): S. 907--908, 2011. , DOI: 10.1002/biot.201100233
• Yu, B and Sun, J and Bommareddy, R R and Song, L and Zeng, A P: Novel (2R,3R)-2,3-butanediol dehydrogenase from potential industrial strain Paenibacillus polymyxa ATCC 12321. Appl Environ Microbiol, 77(12): S. 4230--4233, 2011. , DOI: 10.1128/AEM.02998-10
• Zhang, Qingrui and Xiu, Zhilong and Zeng, An-Ping: Optimization of microbial production of 1,3-propanediol by Klebsiella pneumoniae under anaerobic and microaerobic conditions by metabolic flux analysis. Journal of Chemical Industry and Engineering (China), 57(6): S. 1403--1409, 2006. , http://en.cnki.com.cn/Article\_en/CJFDTOTAL-HGSZ200606025.htm
• Zheng, Ping and Wereath, Kirsten and Sun, Jibin and van den Heuvel, Joop and Zeng, An-Ping: Overexpression of genes of the dha regulon and its effects on cell growth, glycerol fermentation to 1,3-propanediol and plasmid stability in Klebsiella pneumoniae. Process Biochemistry, 41(10): S. 2160--2169, oct 2006. , DOI: 10.1016/j.procbio.2006.06.012, http://linkinghub.elsevier.com/retrieve/pii/S1359511306002479
• Hilterhaus, L and Minow, B and Muller, J and Berheide, M and Quitmann, H and Katzer, M and Thum, O and Antranikian, G and Zeng, A P and Liese, A: Practical application of different enzymes immobilized on sepabeads. Bioprocess Biosyst Eng, 31(3): S. 163--171, 2008. , DOI: 10.1007/s00449-008-0199-3
• H. Zhao, A.-P. Zeng: Preface: Exploring the Synergy between Synthetic Biology and Metabolic Engineering , , Jg. 162 of Synthetic Biology - Metabolic Engineering, S. V-Vi. Springer, , 2017.
• Xiu, Z L and Zeng, A P: Present state and perspective of downstream processing of biologically produced 1,3-propanediol and 2,3-butanediol. Appl Microbiol Biotechnol, 78(6): S. 917--926, 2008. , DOI: 10.1007/s00253-008-1387-4
• Chatzifragkou, A and Papanikolaou, S and Dietz, D and Doulgeraki, A I and Nychas, G J and Zeng, A P: Production of 1,3-propanediol by Clostridium butyricum growing on biodiesel-derived crude glycerol through a non-sterilized fermentation process. Appl Microbiol Biotechnol, 91(1): S. 101--112, 2011. , DOI: 10.1007/s00253-011-3247-x
• Metsoviti, Maria and Paraskevaidi, Kleopatra and Koutinas, Apostolis and Zeng, An-Ping and Papanikolaou, Seraphim: Production of 1,3-propanediol, 2,3-butanediol and ethanol by a newly isolated Klebsiella oxytoca strain growing on biodiesel-derived glycerol based media. Process Biochemistry, 47(12): S. 1872--1882, dec 2012. , DOI: 10.1016/j.procbio.2012.06.011, http://linkinghub.elsevier.com/retrieve/pii/S1359511312002541
• Chen, Zhen and Geng, Feng and Zeng, An-Ping: Protein design and engineering of a de novo pathway for microbial production of 1,3-propanediol from glucose. Biotechnology Journal, 10(2): S. 284--289, feb 2015. , DOI: 10.1002/biot.201400235, http://doi.wiley.com/10.1002/biot.201400235
• Chen Z, Zeng A-P: Protein engineering approaches to chemical biotechnology. Curr Opin Biotechnol(42): S. 198–205, 2016.
• Chen, Zhen and Jandt, Uwe and Rappert, Sugima and Zeng, An-Ping: Proteindesign für die Entwicklung von industriellen Mikroorganismen. BIOspektrum, 19(1): S. 99--101, feb 2013. , DOI: 10.1007/s12268-013-0276-2, http://link.springer.com/10.1007/s12268-013-0276-2
• Wang, W and Sun, J and Hollmann, R and Zeng, A P and Deckwer, W D: Proteomic characterization of transient expression and secretion of a stress-related metalloprotease in high cell density culture of Bacillus megaterium. J Biotechnol, 126(3): S. 313--324, 2006. , DOI: 10.1016/j.jbiotec.2006.05.005
• Chen L, Zeng A-P: Rational Design and Metabolic Analysis of Escherichia coli for Effective Production of L-Tryptophan at High Concentration. Appl Microbiol Biotechnol , 15(101): S. 559-568, 2017. , DOI: doi: 10.1007/s00253-016-7772-5
• Chen, Zhen and Rappert, Sugima and Zeng, An-Ping: Rational Design of Allosteric Regulation of Homoserine Dehydrogenase by a Nonnatural Inhibitor L-Lysine. ACS Synthetic Biology, 4(2): S. 126--131, feb 2015. , DOI: 10.1021/sb400133g, http://pubs.acs.org/doi/abs/10.1021/sb400133g
• Oehmke, Sebastian and Zeng, An-Ping: Recovery of biologically produced 3-hydroxypropionaldehyde and its dehydrated product acrolein. Engineering in Life Sciences: S. n/a--n/a, jun 2014. , DOI: 10.1002/elsc.201300122, http://doi.wiley.com/10.1002/elsc.201300122
• Metsoviti, Maria and Paramithiotis, Spiros and Drosinos, Eleftherios H. and Galiotou-Panayotou, Maria and Nychas, George-John E. and Zeng, An-Ping and Papanikolaou, Seraphim: Screening of bacterial strains capable of converting biodiesel-derived raw glycerol into 1,3-propanediol, 2,3-butanediol and ethanol. Engineering in Life Sciences, 12(1): S. 57--68, feb 2012. , DOI: 10.1002/elsc.201100058, http://doi.wiley.com/10.1002/elsc.201100058
• Aydogan, Özlem and Bayraktar, Emine and Mehmetoğlu, Ülkü and Kaeding, Thomas and Zeng, An-Ping: Selection and optimization of an aqueous two-phase system for the recovery of 1,3-propandiol from fermentation broth. Engineering in Life Sciences, 10(20): S. 121--129, mar 2010. , DOI: 10.1002/elsc.200900084, http://doi.wiley.com/10.1002/elsc.200900084
• Groeger C, Sabra W., Zeng A-P: Simultaneous production of 1, 3‐propanediol and n‐butanol by Clostridium pasteurianum: In situ gas stripping and cellular metabolism. Engineering in Life Sciences(16): S. 664-674, 2016.
• Rieckenberg, F and Gotz, K and Hilterhaus, L and Liese, A and Zeng, A P: Strategies for reliable and improved large-scale production of Pyrococcus furiosus with integrated purification of hydrogenase I. Bioprocess Biosyst Eng, 2014. , DOI: 10.1007/s00449-014-1225-2
• Sabra, W and Dietz, D and Zeng, A P: Substrate-limited co-culture for efficient production of propionic acid from flour hydrolysate. Appl Microbiol Biotechnol, 97(13): S. 5771--5777, 2013. , DOI: 10.1007/s00253-013-4913-y
• Wael Sabra, Rajesh Reddy Bommareddy, Garima Maheshwari, Seraphim Papanikolaou and An-Ping Zeng: Substrates and oxygen dependent citric acid production by Yarrowia lipolytica: Insights through transcriptome and fluxome analyses.. Microbial Cell Factory, 16(78), 2017.
• Hwang E, Seo B, Gu M, Zeng A-P: Successful bi-enzyme stabilization for the biomimetic cascade transformation of carbon dioxide. Catal Sci Techno, 6(19): S. 7267-7272, 2016.
• Cheng-Wei Ma, Li-Bang Zhou and An-Ping Zeng: Synthetic Biology and Metabolic Engineering. Adv. Biochem. Eng. /Biotechnol., Kapitel Engineering Biomolecular Switches for Dynamic Metabolic Control, S. 45-76. Springer, , 2017, DOI: 10.1007/10_2016_9.
• H. Zhao, and A.-P. Zeng: Synthetic Biology–Metabolic Engineering, Jg. 162. Springer, , 2017
• Deckwer, W.-D. and Hempel, D. C. and Zeng, A.-P. and Jahn, D.: Systembiotechnologische Ansätze zur Prozessentwicklung. Chemie Ingenieur Technik, 78(3): S. 193--208, mar 2006. , DOI: 10.1002/cite.200500156, http://doi.wiley.com/10.1002/cite.200500156
• Deckwer, W.-D. and Jahn, D. and Hempel, D. and Zeng, A.-P.: Systems Biology Approaches to Bioprocess Development. Engineering in Life Sciences, 6(5): S. 455--469, oct 2006. , DOI: 10.1002/elsc.200620153, http://doi.wiley.com/10.1002/elsc.200620153
• Sun, J and Zeng, A-P: Systems Biology. In , Hrsg., Report on the Development of Industrial Biotechnology . The Bureau of Life Science & Biotechnology, CAS, Beijing, 2008.